Neutral endopeptidase inhibitors potentiate substance P- and capsaicin-induced cough in awake guinea pigs.

Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones

1977 • 1,284 citations

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

1980 • 705 citations

High-affinity enkephalin-degrading peptidase in brain is increased after morphine

1978 • 652 citations

Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man

1984 • 512 citations

Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants

1983 • 495 citations

Receptors in the trachea and bronchi of the cat

1954 • 471 citations

The purification and specificity of a neutral endopeptidase from rabbit kidney brush border

1974 • 457 citations

A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea pig

1983 • 443 citations

Biological inactivation of enkephalins and the role of enkephalin-dipeptidyl-carboxypeptidase (“enkephalinase”) as neuropeptidase

1981 • 382 citations

Role of Autonomic Nervous System and the Cough Reflex in the Increased Responsiveness of Airways in Patients with Obstructive Airway Disease*

1967 • 376 citations

Substance P release from spinal cord slices by capsaicin

1979 • 376 citations

Structure‐activity relationships for some substance P‐related peptides that cause wheal and flare reactions in human skin.

1983 • 319 citations

Effects and distribution of vagal capsaicin‐sensitive substance P neurons with special reference to the trachea and lungs

1983 • 296 citations

Multiple tachykinins (neurokinin A, neuropeptide K and substance P) in capsaicin-sensitive sensory neurons in the guinea-pig

1985 • 280 citations

Activity of lung irritant receptors in pulmonary micro‐embolism, anaphylaxis and drug‐induced bronchoconstrictions

1969 • 275 citations

Bradykinin-induced bronchoconstriction in humans. Mode of action.

1987 • 260 citations

Neutral metalloendopeptidase in human lung tissue and cultured cells.

1985 • 259 citations

Impulse activity in afferent vagal C-fibres with endings in the intrapulmonary airways of dogs

1977 • 241 citations

Substance P and capsaicin‐induced contraction of human bronchi

1983 • 237 citations

The response of laryngeal afferent fibres to mechanical and chemical stimuli

1974 • 218 citations

Bradykinin stimulates afferent vagal C-fibers in intrapulmonary airways of dogs

1980 • 217 citations

Capsaicin inhalation in man and the effects of sodium cromoglycate

1984 • 206 citations

Are there neuropeptide-specific peptidases?

1985 • 197 citations

Capsaicin‐sensitive vagal neurons involved in control of vascular permeability in rat trachea

1982 • 194 citations

Stimulation of ‘irritant’ receptors and afferent C-fibres in the lungs by prostaglandins

1976 • 186 citations

Membrane bound pituitary metalloendopeptidase: Apparent identity to enkephalinase

1981 • 175 citations

Kidney neutral endopeptidase and the hydrolysis of enkephalin by synaptic membranes show similar sensitivity to inhibitors

1982 • 171 citations

Threshold and odor specificity of pheromone-sensitive neurons in the deutocerebrum ofAntheraea pernyi andA. polyphemus (Saturnidae)

1979 • 132 citations

Regulatory Peptides in the Mammalian Respiratory Tract*

1982 • 131 citations

Enkephalinase inhibitor potentiates substance P- and electrically induced contraction in ferret trachea

1987 • 127 citations

Toluene diisocyanate increases airway responsiveness to substance P and decreases airway neutral endopeptidase.

1988 • 127 citations

Influence of Lung Stretch Receptors on the Cough Reflex in Rabbits

1984 • 116 citations

Enkephalinase activity in rat peripheral organs

1981 • 116 citations

Properties of “enkephalinase” from rat kidney: Comparison of dipeptidyl-carboxypeptidase and endopeptidase activities

1982 • 114 citations

Prostaglandin D2 potentiates airway responsiveness to histamine and methacholine.

1986 • 110 citations

Enkephalinase Inhibitors Potentiate Substance P-Induced Secretion of³⁵SO₄-Macromolecules from Ferret Trachea

1987 • 107 citations

Effects of Inhaled Prostaglandins E1, E2 and F2α on the Airway Resistance of Healthy and Asthmatic Man

1975 • 106 citations

Neuropeptides degranulate serous cells of ferret tracheal glands

1986 • 106 citations

Cough induced by stimulation of capsaicin‐sensitive sensory neurons in conscious guinea‐pigs

1986 • 102 citations

Neutral endopeptidase and angiotensin converting enzyme inhibitors potentiate kinin-induced contraction of ferret trachea.

1988 • 88 citations

Effect of kallidin, substance P, and other basic polypeptides on the production of respiratory macromolecules.

1977 • 72 citations

REFLEX CONTROL OF AIRWAY SIZE*

1963 • 56 citations

Mechanism of substance P-induced bronchoconstriction in maturing rabbit

1984 • 56 citations

Cough: Physiology, evaluation, and treatment

1986 • 55 citations

Substance P, 5-hydroxytryptamine, and bradykinin stimulate abdominal visceral afferents

1986 • 53 citations

Endopeptidase-24.11: a cell-surface enzyme for metabolizing regulatory peptides

1985 • 43 citations

Comparison of the tussive effects of histamine and methacholine in humans

1983 • 39 citations

Respiratory reflexes and defense

1977 • 36 citations

Selective effect of general anesthetics on reflex bronchoconstrictor responses in dogs

1982 • 26 citations