Osmosis and the Regulation of Cell Volume

Physical chemistry of macromolecules

2007 • 3,839 citations

Living with Water Stress: Evolution of Osmolyte Systems

1982 • 3,735 citations

Electrolyte solutions

1960 • 3,290 citations

Appearance of Water Channels in Xenopus Oocytes Expressing Red Cell CHIP28 Protein

1992 • 1,979 citations

Thermodynamics of electrolytes. II. Activity and osmotic coefficients for strong electrolytes with one or both ions univalent

1973 • 1,751 citations

Estimation of macromolecule concentrations and excluded volume effects for the cytoplasm of Escherichia coli

1991 • 1,253 citations

A Text-Book of Physical Chemistry

1936 • 1,216 citations

Filtration, diffusion, and molecular sieving through porous cellulose membranes.

1954 • 1,078 citations

Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane.

1995 • 1,017 citations

Cloning and expression of apical membrane water channel of rat kidney collecting tubule

1993 • 1,002 citations

Membrane mechanisms in volume and pH regulation in vertebrate cells

1989 • 880 citations

Elastic deformation and failure of lipid bilayer membranes containing cholesterol

1990 • 824 citations

Potassium accumulation in muscle and associated changes1

1941 • 798 citations

Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.

1991 • 795 citations

Cytoskeleton—Plasma Membrane Interactions

1992 • 792 citations

Mechanosensitive ion channels

1990 • 721 citations

Regulation of Cell Volume by Active Cation Transport in High and Low Potassium Sheep Red Cells

1960 • 671 citations

Aquaporin CHIP: the archetypal molecular water channel

1993 • 670 citations

Molecular structure of the water channel through aquaporin CHIP. The hourglass model.

1994 • 632 citations

Regulation of cellular volume.

1977 • 607 citations

Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein

1992 • 588 citations

The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel.

1993 • 580 citations

Measurement of forces between lecithin bilayers

1976 • 562 citations

CHIP28 water channels are localized in constitutively water-permeable segments of the nephron.

1993 • 543 citations

The effect of volume occupancy upon the thermodynamic activity of proteins: some biochemical consequences

1983 • 503 citations

Cellular and Molecular Physiology of Cell Volume Regulation

2020 • 499 citations

Pathophysiology of the Aquaporin Water Channels

1996 • 492 citations

Membrane Mechanisms and Intracellular Signalling in Cell Volume Regulation

1995 • 469 citations

Effects of unstirred layers on membrane phenomena.

1984 • 451 citations

Elastic area compressibility modulus of red cell membrane

1976 • 447 citations

Water movement through lipid bilayers, pores, and plasma membranes : theory and reality

1987 • 441 citations

Responses of lymphocytes to anisotonic media: volume-regulating behavior

1984 • 427 citations

Mediation of cell volume regulation by Ca2+ influx through stretch-activated channels

1987 • 418 citations

Anisosmotic cell volume regulation: a comparative view

1989 • 394 citations

Cloning of a Na(+)- and Cl(-)-dependent betaine transporter that is regulated by hypertonicity.

1992 • 393 citations

The movement of molecules across lipid membranes: A molecular theory

1971 • 390 citations

Osmoregulatory Salt Transporting Mechanisms: Control of Cell Volume in Anisotonic Media

1981 • 360 citations

Inhibition of water and solute permeability in human red cells

1970 • 358 citations

Calcium signaling in cell volume regulation

1992 • 349 citations

Function follows form: generation of intracellular signals by cell deformation

1991 • 345 citations

Protons, osmolytes, and fitness of internal milieu for protein function

1986 • 340 citations

THE RATE OF EXCHANGE OF TRITIATED WATER ACROSS THE HUMAN RED CELL MEMBRANE

1957 • 340 citations

Cloning of the cDNa for a Na+/myo-inositol cotransporter, a hypertonicity stress protein.

1992 • 336 citations

Water transport across mammalian cell membranes

1996 • 329 citations

Permeability of lipid bilayers to water and ionic solutes

1986 • 321 citations

The Water and Nonelectrolyte Permeability Induced in Thin Lipid Membranes by the Polyene Antibiotics Nystatin and Amphotericin B

1970 • 317 citations

On the mechanism of fluid exchange of tissues in vitro

1956 • 309 citations

Activation of ion transport pathways by changes in cell volume

1991 • 306 citations

The Na-K-Cl cotransporters

1994 • 304 citations

Water permeability of lipid membranes.

1980 • 301 citations

Regulation of cell function by the cellular hydration state

1994 • 270 citations

Permeability and Electrical Properties of Thin Lipid Membranes

1968 • 255 citations

Water Permeability of Thin Lipid Membranes

1967 • 246 citations

Die Rolle des osmotischen Druckes in der Analogie zwischen Lösungen und Gasen

1887 • 240 citations

Okadaic acid inhibition of KCl cotransport. Evidence that protein dephosphorylation is necessary for activation of transport by either cell swelling or N-ethylmaleimide.

1991 • 236 citations

The Donnan Equilibrium

1956 • 234 citations

Cell volume in the regulation of hepatic function: a mechanism for metabolic control

1991 • 225 citations

Study of the relationship between bilayer water permeability and bilayer physical state

1983 • 222 citations

Equations of Membrane Biophysics

1984 • 216 citations

Activation of Na+/H+ exchange in lymphocytes by osmotically induced volume changes and by cytoplasmic acidification.

1983 • 209 citations

Kinetics of activation and inactivation of swelling-stimulated K+/Cl- transport. The volume-sensitive parameter is the rate constant for inactivation.

1990 • 200 citations

Water movement through lipid bilayers, pores, and plasma membranes

1987 • 198 citations

Glucose transporters serve as water channels.

1990 • 197 citations

MAINTENANCE OF CONCENTRATION GRADIENTS AND REGULATION OF CELL VOLUME

1959 • 197 citations

Incorporation of cytoplasmic vesicles into apical membrane of mammalian urinary bladder epithelium

1982 • 189 citations

Cell shape: Determinants, regulation, and regulatory role

1990 • 180 citations

A comparative study of diffusive and osmotic water permeation across bilayers composed of phospholipids with different head groups and fatty acyl chains

1995 • 176 citations

Ionic and osmotic equilibria of human red blood cells treated with nystatin.

1979 • 176 citations

THE AQUEOUS PORE IN THE RED CELL MEMBRANE: BAND 3 AS A CHANNEL FOR ANIONS, CATIONS, NONELECTROLYTES, AND WATER*

1983 • 175 citations

Model for the role of macromolecular crowding in regulation of cellular volume.

1992 • 173 citations

Anion channels for amino acids in MDCK cells

1992 • 172 citations

Separate, Ca2+-activated K+ and Cl− transport pathways in Ehrlich ascites tumor cells

1986 • 170 citations

Nature of Solvent Transfer in Osmosis

1957 • 168 citations

Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis.

1994 • 163 citations

Involvement of calcium and cytoskeleton in gallbladder epithelial cell volume regulation

1985 • 160 citations

The volume-sensitive organic osmolyte-anion channel VSOAC is regulated by nonhydrolytic ATP binding

1994 • 156 citations

Water permeability of gramicidin A-treated lipid bilayer membranes.

1978 • 154 citations

SOLUBILITIES OF WATER IN SEVERAL NORMAL ALKANES FROM C₇ TO C₁₆¹

1963 • 154 citations

Ionic Mechanisms of Cell Volume Regulation in Leukocytes

1990 • 154 citations

A Multifunctional Aqueous Channel Formed by CFTR

1992 • 152 citations

Hepatic Transport Systems Regulating pHi, Cell Volume, and Bile Secretion

1992 • 149 citations

Regulation of cellular volume in rabbit ventricular myocytes: bumetanide, chlorothiazide, and ouabain

1991 • 141 citations

Cloning, functional analysis and cell localization of a kidney proximal tubule water transporter homologous to CHIP28.

1993 • 140 citations

Role of organic osmolytes in adaptation of renal cells to high osmolality

1991 • 140 citations

Ca2+-Activated Cell Volume Recovery Mechanisms

1990 • 134 citations

Membrane recycling and epithelial cell function

1989 • 133 citations

Cell swelling and ion transport pathways in cardiac myocytes

1996 • 132 citations

Cell volume and hormone action

1992 • 129 citations

Interactions of cell volume, membrane potential, and membrane transport parameters

1980 • 125 citations

Stretch-activated ion channels

1995 • 122 citations

The regulation of Na/K/2Cl cotransport and bumetanide binding in avian erythrocytes by protein phosphorylation and dephosphorylation. Effects of kinase inhibitors and okadaic acid.

1990 • 121 citations

Medium tonicity regulates expression of the Na(+)- and Cl(-)-dependent betaine transporter in Madin-Darby canine kidney cells by increasing transcription of the transporter gene.

1993 • 121 citations

Functional unit of 30 kDa for proximal tubule water channels as revealed by radiation inactivation.

1991 • 120 citations

A theory of partial osmotic pressures and membrane equilibria, with special reference to the application of Dalton's Law to hæmoglobin solutions in the presence of salts

1928 • 120 citations

The three-dimensional structure of human erythrocyte aquaporin CHIP.

1994 • 120 citations

Amino acid loss during volume regulatory decrease in cultured chick heart cells

1993 • 120 citations

Current understanding of the cellular biology and molecular structure of the antidiuretic hormone-stimulated water transport pathway.

1991 • 118 citations

Contraction‐associated translocation of protein kinase C in rat skeletal muscle

1987 • 117 citations

Tissue-specific expression of mRNA encoding rat kidney water channel CHIP28k by in situ hybridization

1993 • 116 citations

Water transport across biological membranes

1994 • 112 citations

Principles of Cell Volume Regulation

1988 • 110 citations

Molecular Mechanisms of NaCl Cotransport

1996 • 106 citations

Structure of the Osmo-regulated H2O-channel, AQP-CHIP, in Projection at 3.5 Å Resolution

1995 • 97 citations

Osmotische Untersuchungen; Studien zur Zellmechanik

1921 • 96 citations

Quantitative Analysis of Aquaporin mRNA Expression in Rat Tissues by RNase Protection Assay

1996 • 92 citations

K-Cl cotransport in rabbit red cells: further evidence for regulation by protein phosphatase type 1

1993 • 85 citations

Coordinated regulation of shrinkage-induced Na/H exchange and swelling-induced [K-Cl] cotransport in dog red cells. Further evidence from activation kinetics and phosphatase inhibition.

1991 • 85 citations

Interaction of the plasma membrane with the cytoskeleton: An overview

1983 • 83 citations

Cytosolic protein concentration is the primary volume signal for swelling-induced [K-Cl] cotransport in dog red cells.

1992 • 82 citations

Mechanical study of the deformation and rupture of the plasma membranes of protoplasts during osmotic expansions

1986 • 77 citations

Intermediate Physics for Medicine and Biology

1979 • 74 citations

Antidiuretic hormone moves membranes

1988 • 74 citations

An Analysis of Unstirred Layers in Series with "Tight" and "Porous" Lipid Bilayer Membranes

1971 • 73 citations

Osmotic water permeability of the human red cell. Dependence on direction of water flow and cell volume.

1983 • 73 citations

Changes in cell volume measured with an electrophysiologic technique.

1985 • 71 citations

Modulation of rabbit ventricular cell volume and Na+/K+/2Cl- cotransport by cGMP and atrial natriuretic factor.

1992 • 71 citations

Dog Red Blood Cells

1973 • 67 citations

Properties of Water Channels in Human Red Cells

1972 • 66 citations

Endothelial dysfunction in the coronary microcirculation: a new clinical entity or an experimental finding?

1993 • 65 citations

Cytosolic protein concentration is the primary volume signal in dog red cells.

1991 • 64 citations

Dog Red Blood Cells

1973 • 64 citations

Swelling-activated KCl cotransport in rabbit red cells: flux is determined mainly by cell volume rather than shape

1990 • 61 citations

Prevention of myocardial intracellular edema induced by St. Thomas' Hospital cardioplegic solution

1991 • 61 citations

Osmotic gradient-induced water permeation across the sarcolemma of rabbit ventricular myocytes.

1996 • 59 citations

Holobiochemistry: The effect of local environment upon the equilibria and rates of biochemical reactions

1990 • 57 citations

A Potassium-Selective Channel in Isolated Lymnaea Stagnalis Heart Muscle Cells

1986 • 55 citations

EXPERIMENTAL STUDY OF OSMOSIS THROUGH A COLLODION MEMBRANE

1958 • 51 citations

T4 polynucleotide kinase: Macromolecular crowding increases the efficiency of reaction at DNA termini

1986 • 50 citations

Ion Channels as Mechanical Transducers

1989 • 50 citations

Characteristics and Regulation of the Na/K/2CI Cotransporter

1992 • 49 citations

Significant stabilization of the phosphatidylcholine bilayer structure by incorporation of small amounts of cardiolipin

1994 • 49 citations

Stretch-activated channel blockers modulate cell volume in cardiac ventricular myocytes

1995 • 48 citations

Regulation of the Predominant Renal Medullary Organic Solutes In Vivo

1990 • 45 citations

THE EFFECTS OF SELECTED CELL OSMOLYTES ON THE ACTIVITY OF LACTATE DEHYDROGENASE FROM THE EURYHALINE POLYCHAETE,NEREIS SUCCINEA

1977 • 43 citations

The State of Water and Alkali Cations within the Intracellular Fluids: The Contribution of NMR Spectroscopy

1977 • 42 citations

cGMP and Atrial Natriuretic Factor Regulate Cell Volume of Rabbit Atrial Myocytes

1995 • 40 citations

Osmotic behaviour of human red blood cells: an interpretation in terms of negative intracellular fluid pressure

1978 • 38 citations

Macromolecular crowding accelerates the cohesion of DNA fragments with complementary termini

1985 • 37 citations

The role of ion content and cell volume in insulin action

1994 • 33 citations

Molecular mechanisms of osmosis

1989 • 32 citations

Transport of Water and Nonelectrolytes Across Red Cell Membranes

1979 • 32 citations

A 30 kDa functional size for the erythrocyte water channel determined in situ by radiation inactivation

1992 • 30 citations

The effect of cytochalasin B on the volume regulation response of isolated axons of the green crab Carcinus maenas submitted to hypo-osmotic media

1986 • 30 citations

[11] Water channels across the red blood cell and other biological membranes

1989 • 28 citations

Kinetic analysis of water transport through a single-file pore.

1992 • 27 citations

An algorithm for writing down flux equations for carrier kinetics, and its application to co-transport

1976 • 26 citations

Volume-activated cation transport in dog red cells: Detection and transduction of the volume stimulus

1992 • 18 citations

Water and electrolyte content of the myofilament phase in the chemically skinned barnacle fiber.

1980 • 15 citations

Predictions and tests of a new integrated reticulocyte model: implications for dehydration of sickle cells.

1989 • 4 citations