Validating cancer drug targets

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

2004 • 9,201 citations

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

2005 • 6,083 citations

EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib

2004 • 4,293 citations

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

2004 • 3,304 citations

Erlotinib in Lung Cancer — Molecular and Clinical Predictors of Outcome

2005 • 1,834 citations

High frequency of BRAF mutations in nevi

2002 • 1,701 citations

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

2005 • 1,478 citations

Molecular Determinants of the Response of Glioblastomas to EGFR Kinase Inhibitors

2005 • 1,418 citations

The Concept of Synthetic Lethality in the Context of Anticancer Therapy

2005 • 1,324 citations

The development of imatinib as a therapeutic agent for chronic myeloid leukemia

2004 • 1,231 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

2005 • 873 citations

Isolation of a transforming sequence from a human bladder carcinoma cell line

1982 • 776 citations

Integrating Genetic Approaches into the Discovery of Anticancer Drugs

1997 • 757 citations

The PIK3CA gene is mutated with high frequency in human breast cancers

2004 • 654 citations

ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines

2005 • 490 citations

The estrogen receptor: a model for molecular medicine.

2003 • 461 citations

Epidermal Growth Factor Receptor Mutations in Non–Small-Cell Lung Cancer: Implications for Treatment and Tumor Biology

2005 • 403 citations

Zebrafish as a cancer model system

2002 • 357 citations

What's wrong with our cancer models?

2005 • 323 citations

Raf: A Strategic Target for Therapeutic Development Against Cancer

2005 • 292 citations

Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells

2003 • 279 citations

The Akt Pathway: Molecular Targets for Anti-Cancer Drug Development

2004 • 250 citations

The role of the androgen receptor in the development and progression of prostate cancer.

1999 • 245 citations

Using Drosophila melanogaster to map human cancer pathways

2005 • 240 citations

Intrinsic Mechanism of Estradiol-Induced Apoptosis in Breast Cancer Cells Resistant to Estrogen Deprivation

2005 • 235 citations

Use of isogenic human cancer cells for high-throughput screening and drug discovery

2001 • 228 citations

Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery

2005 • 217 citations

Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins

2004 • 215 citations

The Role of the Epidermal Growth Factor Receptor Family in Mammary Tumorigenesis and Metastasis

1999 • 190 citations

Relevance of ultraviolet-induced N-ras oncogene point mutations in development of primary human cutaneous melanoma.

1996 • 164 citations

Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses

2004 • 164 citations

Neoplastic transformation of normal hematopoietic cells by constitutively activating mutations of c-kit receptor tyrosine kinase

1996 • 140 citations

Targeting Ras and Rho GTPases as opportunities for cancer therapeutics

2004 • 120 citations

Transgenic expression of PML/RARalpha impairs myelopoiesis.

1996 • 107 citations

Trastuzumab: targeted therapy for the management of HER-2/neu-overexpressing metastatic breast cancer.

2005 • 104 citations

RNA-interference-based functional genomics in mammalian cells: reverse genetics coming of age

2004 • 101 citations

Comparative analysis of genes regulated by PML/RARα and PLZF/RARα in response to retinoic acid using oligonucleotide arrays

2003 • 87 citations

Induction of Aromatase Expression in Cervical Carcinomas: Effects of Endogenous Estrogen on Cervical Cancer Cell Proliferation

2005 • 86 citations

Roles of Stem Cell Factor/c-Kit and Effects of Glivec®/STI571 in Human Uveal Melanoma Cell Tumorigenesis

2004 • 84 citations

Promises and challenges of targeting Bcl-2 anti-apoptotic proteins for cancer therapy

2004 • 81 citations

Retinoid target genes in acute promyelocytic leukemia

2003 • 72 citations

Expression of estrogen receptor α, retinoic acid receptor α and cellular retinoic acid binding protein II genes is coordinately regulated in human breast cancer cells

2005 • 64 citations

Tamoxifen versus Aromatase Inhibitors for Breast Cancer Prevention

2005 • 51 citations

Encouraging Results for Second-Generation Antiangiogenesis Drugs

2005 • 51 citations

Inhibiting the growth of malignant melanoma by blocking the expression of vascular endothelial growth factor using an RNA interference approach

2005 • 37 citations

An in vitro Study on the Suppressive Effect of Glioma Cell Growth Induced by Plasmid-Based Small Interference RNA (siRNA) Targeting Human Epidermal Growth Factor Receptor

2005 • 35 citations

Cancer drug discovery through collaboration

2005 • 29 citations

Measurement of a linear free energy relationship one molecule at a time

2004 • 22 citations

Yeast as a model system for anticancer drug discovery

2001 • 21 citations

Mutation of the Androgen Receptor Causes Oncogenic Transformation of the Prostate

2005 • 12 citations

Targeting non-small cell lung cancer with epidermal growth factor tyrosine kinase inhibitors: where do we stand, where do we go

2004 • 10 citations

Early events in leukemogenesis in P190Bcr-abl transgenic mice

2000 • 8 citations

Fine allelotyping of Erbb2‐induced mammary tumors in mice reveals multiple discontinuous candidate regions of tumor‐suppressor loci

2005 • 5 citations

Target Selection Issues in Drug Discovery and Development

2004 • 2 citations