The role of pyruvate in neuronal calcium homeostasis. Effects on intracellular calcium pools.

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores

1989 • 1,616 citations

Mitochondrial Membrane Potential in Living Cells

1988 • 1,010 citations

Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin

1992 • 920 citations

Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture

1989 • 492 citations

Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen

1989 • 376 citations

Ca2+-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons

1992 • 336 citations

Protection of Dentate Hilar Cells from Prolonged Stimulation by Intracellular Calcium Chelation

1989 • 292 citations

Relative mitochondrial membrane potential and [Ca2+]i in type I cells isolated from the rabbit carotid body.

1992 • 246 citations

Sustained increase in intracellular calcium promotes neuronal survival

1991 • 213 citations

2,5‐Di(tert‐butyl)‐1,4‐benzohydroquinone — a novel inhibitor of liver microsomal Ca²⁺ sequestration

1987 • 204 citations

Non-ohmic proton conductance of the mitochondrial inner membrane in hepatocytes.

1990 • 184 citations

Calcium-induced release of calcium regulates differentiation of cultured spinal neurons

1991 • 175 citations

Intracellular Ca2+ pools in PC12 cells. Three intracellular pools are distinguished by their turnover and mechanisms of Ca2+ accumulation, storage, and release.

1991 • 171 citations

Intracellular Ca2+ storage organelles in non-muscle cells: Heterogeneity and functional assignment

1990 • 160 citations

Evidence that nerve growth factor dependence of sympathetic neurons for survival in vitro may be determined by levels of cytoplasmic free Ca2+.

1991 • 159 citations

Synaptosomal bioenergetics

1986 • 149 citations

α‐Ketoglutarate and Malate Uptake and Metabolism by Synaptosomes: Further Evidence for an Astrocyte‐to‐Neuron Metabolic Shuttle

1984 • 143 citations

Pyruvate participation in the low molecular weight trophic activity for central nervous system neurons in glia-conditioned media

1985 • 135 citations

Is Alzheimer's disease an anterograde degeneration, originating in the brainstem, and disrupting metabolic and functional interactions between neurons and glial cells?

1989 • 108 citations

Release of intracellular calcium and modulation of membrane currents by caffeine in bull‐frog sympathetic neurones.

1992 • 104 citations

Calcium binding to the cytosol and calcium extrusion mechanisms in intact synaptosomes and their alterations with aging.

1992 • 102 citations

[4] Firefly luciferase assay for ATP production by mitochondria

1978 • 99 citations

Neuron-specific and state-specific differences in calcium homeostasis regulate the generation and degeneration of neuronal architecture

1990 • 96 citations

Involvement of mitochondria in the age-dependent decrease in calcium uptake of rat brain synaptosomes

1986 • 93 citations

Influence of the Malate‐Aspartate Shuttle on Oxidative Metabolism in Synaptosomes

1988 • 86 citations

Thapsigargin, but not caffeine, blocks the ability of thyrotropin-releasing hormone to release Ca2+ from an intracellular store in GH4C1 pituitary cells

1990 • 80 citations

The identity of the calcium-storing, inositol 1,4,5—trisphosphate-sensitive organelle in non-muscle cells: calciosome, endoplasmic reticulum … or both?

1991 • 80 citations

Carbon Dioxide Fixation in Neuronal and Astroglial Cells in Culture

1992 • 78 citations

The mechanism of stimulation of respiration by fatty acids in isolated hepatocytes.

1990 • 77 citations

Glucagon effects on the membrane potential and calcium uptake rate of rat liver mitochondria.

1984 • 74 citations

Dependence of cytosolic calcium in differentiating rat pheochromocytoma cells on calcium channels and intracellular stores.

1991 • 68 citations

Age‐Dependent Variations in Peroxide‐Utilizing Enzymes from Rat Brain Mitochondria and Cytoplasm

1984 • 65 citations

Inhibition of high-affinity gamma-aminobutyric acid uptake in primary astrocyte cultures by phorbol esters and phospholipase C

1991 • 61 citations

Nutritional requirements for growth of a mouse lymphoma in cell culture

1960 • 58 citations

In situ imaging of agonist-sensitive calcium pools in AR4-2J pancreatoma cells. Evidence for an agonist- and inositol 1,4,5-trisphosphate-sensitive calcium pool in or closely associated with the nuclear envelope.

1992 • 51 citations

Neuronal Ca2+: getting it up and keeping it up

1992 • 48 citations

Regulation of Ca2+ transport by isolated organelles of a rat insulinoma. Studies with endoplasmic reticulum and secretory granules.

1984 • 48 citations

A digitized-fluorescence-imaging study of mitochondrial Ca2+ increase by doxorubicin in cardiac myocytes

1992 • 44 citations

FCCP releases Ca2+ from a non-mitochondrial store in an identifiedHelisoma neuron

1991 • 36 citations

Regulation of cytosolic free calcium concentration by intrasynaptic mitochondria.

1992 • 33 citations

The role of lactic acid in autocrine B-cell growth stimulation.

1991 • 31 citations

NMDA-induced increase in [Ca2+]i and45Ca2+ uptake in acutely dissociated brain cells derived from adult rats

1992 • 30 citations

Compartmentation and regulation of acetylcholine synthesis at the synapse

1986 • 27 citations

Specific Replacements of Pyruvate for Trophic Support of Central and Peripheral Nervous System Neurons

1985 • 25 citations

Conditions Restricting Depolarization‐Dependent Calcium Influx in Synaptosomes Reveal a Graded Response of P96 Dephosphorylation and a Transient Dephosphorylation of P65

1991 • 12 citations

Transamination of glutamate to tricarboxylic acid-cycle intermediates in cultured neurons correlates with the ability of oxo acids to support neuronal survival in vitro

1986 • 6 citations