Structural interpretation of the mutations in the beta-cardiac myosin that have been implicated in familial hypertrophic cardiomyopathy.

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

The relation between the divergence of sequence and structure in proteins.

1986 • 2,373 citations

Three-dimensional structure of myosin subfragment-1: a molecular motor

1993 • 2,027 citations

Structure of the actin-myosin complex and its implications for muscle contraction

1993 • 1,756 citations

Atomic model of the actin filament

1990 • 1,657 citations

A molecular basis for familial hypertrophic cardiomyopathy: A β cardiac myosin heavy chain gene missense mutation

1990 • 1,332 citations

α-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: A disease of the sarcomere

1994 • 1,008 citations

Gene Mutations in Human Hæmoglobin: the Chemical Difference Between Normal and Sickle Cell Hæmoglobin

1957 • 938 citations

Characteristics and Prognostic Implications of Myosin Missense Mutations in Familial Hypertrophic Cardiomyopathy

1992 • 732 citations

Force measurements by micromanipulation of a single actin filament by glass needles

1988 • 672 citations

Mapping a Gene for Familial Hypertrophic Cardiomyopathy to Chromosome 14q1

1989 • 526 citations

Myosin subfragment-1 is sufficient to move actin filaments in vitro

1987 • 484 citations

Myosin Structure and Function in Cell Motility

1987 • 479 citations

The Mechanism of Muscle Contractio

1986 • 424 citations

Molecular structure of F-actin and location of surface binding sites

1990 • 382 citations

Structural relationships of actin, myosin, and tropomyosin revealed by cryo-electron microscopy.

1987 • 248 citations

Skeletal muscle expression and abnormal function of beta-myosin in hypertrophic cardiomyopathy.

1993 • 239 citations

Differences in clinical expression of hypertrophic cardiomyopathy associated with two distinct mutations in the beta-myosin heavy chain gene. A 908Leu----Val mutation and a 403Arg----Gln mutation.

1992 • 232 citations

Genotype-phenotype correlations in hypertrophic cardiomyopathy. Insights provided by comparisons of kindreds with distinct and identical beta-myosin heavy chain gene mutations.

1994 • 223 citations

The limited tryptic cleavage of chymotryptic S-1 : An approach to the characterization of the actin site in myosin heads

1979 • 206 citations

Missense mutations in the beta-myosin heavy-chain gene cause central core disease in hypertrophic cardiomyopathy.

1993 • 203 citations

Heterologous expression of a cardiomyopathic myosin that is defective in its actin interaction.

1994 • 202 citations

Mapping of a novel gene for familial hypertrophic cardiomyopathy to chromosome 11

1993 • 186 citations

The complete sequence of the human β-myosin heavy chain gene and a comparative analysis of its product

1990 • 178 citations

Sporadic hypertrophic cardiomyopathy due to de novo myosin mutations.

1992 • 143 citations

Structure of Sickled Erythrocytes and of Sickle-Cell Hemoglobin Fibers

1973 • 140 citations

Active site trapping of nucleotides by crosslinking two sulfhydryls in myosin subfragment 1.

1979 • 139 citations

The substructure of heavy meromyosin. The effect of Ca2+ and Mg2+ on the tryptic fragmentation of heavy meromyosin.

1975 • 119 citations

Force-Generating Domain of Myosin Motor

1993 • 104 citations

Effect of nucleotide binding on the proximity of the essential sulfhydryl groups of myosin. Chemical probing of movement of residues during conformational transitions

1977 • 99 citations

The three-dimensional structure of a molecular motor

1994 • 96 citations

Familial hypertrophic cardiomyopathy. Microsatellite haplotyping and identification of a hot spot for mutations in the beta-myosin heavy chain gene.

1993 • 90 citations

Spatial proximity of the two essential sulfhydryl groups of myosin

1974 • 89 citations

The Primary Structure of Skeletal Muscle Myosin Heavy Chain: IV. Sequence of the Rod, and the Complete 1,938-Residue Sequence of the Heavy Chain

1991 • 83 citations

Flexibility of the myosin heavy chain: direct evidence that the region containing SH1 and SH2 can move 10 .ANG. under the influence of nucleotide binding

1988 • 70 citations

On the origin and transmission of force in actomyosin subfragment 1.

1989 • 68 citations

Foerster energy transfer measurements of thiol 1 to thiol 2 distances in myosin subfragment 1

1983 • 67 citations

A new missense mutation, Arg719Gln, in the β-cardiac heavy chain myosin gene of patients with familial hypertrophic cardiomyopathy

1994 • 51 citations

Novel missense mutation in cardiac β myosin heavy chain gene found in a japanese patient with hypertrophic cardiomyopathy

1992 • 46 citations

Photochemical mapping of the active site of myosin

1992 • 36 citations

Fluorescence energy transfer studies on the proximity of the two essential thiols of myosin subfragment-1.

1983 • 29 citations

A Missense Mutation of Cardiac β-Myosin Heavy Chain Gene Linked to Familial Hypertrophic Cardiomyopathy in Affected Japanese Families

1993 • 28 citations

Identification of a mutation in the beta cardiac myosin heavy chain gene in a family with hypertrophic cardiomyopathy.

1993 • 26 citations