Proinflammatory Mediators Chronically Downregulate the Formation of the Endothelium-Derived Hyperpolarizing Factor in Arteries Via a Nitric Oxide/Cyclic GMP–Dependent Mechanism

Identification of Epoxyeicosatrienoic Acids as Endothelium-Derived Hyperpolarizing Factors

1996 • 1,226 citations

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.

1993 • 778 citations

Oxidized Low-density Lipoprotein Decreases the Expression of Endothelial Nitric Oxide Synthase

1995 • 547 citations

Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway

1990 • 462 citations

Nitric Oxide Attenuates the Release of Endothelium-Derived Hyperpolarizing Factor

1996 • 433 citations

Characterization of endothelium‐derived hyperpolarizing factor as a cytochrome P450‐derived arachidonic acid metabolite in mammals.

1994 • 430 citations

Chronic treatment with polyethylene-glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits.

1991 • 403 citations

Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants.

1993 • 287 citations

Endothelial dysfunction and atherosclerosis

1997 • 250 citations

Endothelium-derived hyperpolarizing factor(s): updating the unknown

1997 • 208 citations

A transferable, beta‐naphthoflavone‐inducible, hyperpolarizing factor is synthesized by native and cultured porcine coronary endothelial cells.

1996 • 174 citations

Regulation and Functional Consequences of Endothelial Nitric Oxide Formation

1995 • 163 citations

Anti-EDRF effect of tumor necrosis factor in isolated, perfused cat carotid arteries

1989 • 123 citations

Increase of an endogenous inhibitor of nitric oxide synthesis in serum of high cholesterol fed rabbits

1994 • 116 citations

Role of nitric oxide in the cytokine-mediated regulation of cytochrome P-450.

1996 • 111 citations

Inhibitors of the cytochrome P450‐mono‐oxygenase and endothelium‐dependent hyperpolarizations in the guinea‐pig isolated carotid artery

1996 • 109 citations

Endothelial dysfunction and atherosclerosis

1997 • 104 citations

Mechanisms of Abnormal Endothelium-Dependent Vascular Relaxation in Atherosclerosis: Implications for Altered Autocrine and Paracrine Functions of EDRF

1989 • 92 citations

Effects of cytochrome P450 inhibitors on EDHF‐mediated relaxation in the rat hepatic artery

1996 • 86 citations

Inhibition of Inducible Nitric Oxide Synthase Restores Endothelium-Dependent Relaxations in Proinflammatory Mediator-Induced Blood Vessels

1997 • 85 citations

cGMP mediates the desensitization to bradykinin in isolated canine coronary arteries

1995 • 61 citations

Selective inhibition by barbiturates of the synthesis of endothelium‐derived hyperpolarizing factor in the rabbit carotid artery

1995 • 61 citations

Effect of nitro‐L‐arginine on endothelium‐dependent hyperpolarizations and relaxations of pig coronary arteries.

1992 • 45 citations

Human Umbilical Vein Endothelial Cells Express P450 2C8 mRNA: Cloning of Endothelial P450 Epoxygenase

1996 • 39 citations

N-α-Tosyl-<scp>l</scp>-Lysine Chloromethylketone Prevents Expression of iNOS in Vascular Smooth Muscle by Blocking Activation of NF-κB

1997 • 22 citations

Platelet inhibition by an L-arginine-derived substance released by IL-1 beta-treated vascular smooth muscle cells

1991 • 22 citations