Endothelium-derived hyperpolarizing factor(s): updating the unknown

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Physiological roles and properties of potassium channels in arterial smooth muscle

1995 • 2,146 citations

Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle

1994 • 1,704 citations

Identification of Epoxyeicosatrienoic Acids as Endothelium-Derived Hyperpolarizing Factors

1996 • 1,226 citations

How is the level of free arachidonic acid controlled in mammalian cells?

1982 • 1,193 citations

Eicosonoid metabolism and beta-adrenergic mechanisms in coronary arterial smooth muscle: potential compartmentation of cAMP

1986 • 795 citations

Endothelium‐dependent hyperpolarization of canine coronary smooth muscle

1988 • 785 citations

Pharmacology of Cannabinoid Receptors

1995 • 485 citations

Endothelium-dependent hyperpolarization: a role in the control of vascular tone

1995 • 440 citations

Nitric Oxide Attenuates the Release of Endothelium-Derived Hyperpolarizing Factor

1996 • 433 citations

Characterization of endothelium‐derived hyperpolarizing factor as a cytochrome P450‐derived arachidonic acid metabolite in mammals.

1994 • 430 citations

Hyperpolarization and relaxation of arterial smooth muscle caused by nitric oxide derived from the endothelium

1990 • 400 citations

Evidence that nitric oxide does not mediate the hyperpolarization and relaxation to acetylcholine in the rat small mesenteric artery

1992 • 356 citations

Endothelium-dependent inhibitory effects of acetylcholine, adenosine triphosphate, thrombin and arachidonic acid in the canine femoral artery.

1982 • 345 citations

Cytochrome P-450 Metabolism of Arachidonic Acid

1991 • 290 citations

Cyclic guanosine monophosphate inhibition of contraction may be mediated through inhibition of phosphatidylinositol hydrolysis in rat aorta.

1986 • 282 citations

Gap Junctions in Vascular Tissues

1996 • 270 citations

Dye Tracers Define Differential Endothelial and Smooth Muscle Coupling Patterns Within the Arteriolar Wall

1995 • 264 citations

Intracellular calcium, currents, and stimulus-response coupling in endothelial cells.

1993 • 260 citations

An Endogenous Cannabinoid as an Endothelium-Derived Vasorelaxant

1996 • 260 citations

Mechanisms of action of noradrenaline and carbachol on smooth muscle of guinea‐pig anterior mesenteric artery.

1984 • 251 citations

Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain

1995 • 234 citations

Potentiation of endothelium-dependent relaxations to bradykinin by angiotensin I converting enzyme inhibitors in canine coronary artery involves both endothelium-derived relaxing and hyperpolarizing factors.

1992 • 221 citations

Cytochrome P450 mono‐oxygenase‐regulated signalling of Ca2+ entry in human and bovine endothelial cells.

1995 • 214 citations

Activation of K+ channel in vascular smooth muscles by cytochrome P450 metabolites of arachidonic acid

1993 • 196 citations

NO^•, CO and ^•OH Endogenous soluble guanylyl cyclase‐activating factors

1992 • 192 citations

Endothelium‐derived factors and hyperpolarization of the carotid artery of the guinea‐pig

1996 • 174 citations

Alteration of cytoplasmic ionized calcium levels in smooth muscle by vasodilators in the ferret.

1984 • 152 citations

Mechanism of the Hypotensive Action of Anandamide in Anesthetized Rats

1996 • 152 citations

Stretch revealed three components in the hyperpolarization of guinea‐pig coronary artery in response to acetylcholine.

1993 • 141 citations

Endothelium‐dependent relaxation and noradrenaline sensitivity in mesenteric resistance arteries of streptozotocin‐induced diabetic rats

1992 • 140 citations

Hydrogen peroxide: An endogenous smooth muscle cell hyperpolarizing factor

1991 • 113 citations

Hydroxyl radical mediates the endothelium-dependent relaxation produced by bradykinin in mouse cerebral arterioles.

1987 • 110 citations

Inhibitors of the cytochrome P450‐mono‐oxygenase and endothelium‐dependent hyperpolarizations in the guinea‐pig isolated carotid artery

1996 • 109 citations

Potential Biosynthetic Connections between the Two Cannabimimetic Eicosanoids, Anandamide and 2-Arachidonoyl-Glycerol, in Mouse Neuroblastoma Cells

1996 • 95 citations

Isoproterenol causes hyperpolarization through opening of ATP-sensitive potassium channels in vascular smooth muscle of the canine saphenous vein.

1995 • 94 citations

Effects of cytochrome P450 inhibitors on EDHF‐mediated relaxation in the rat hepatic artery

1996 • 86 citations

Effects of cyclic nucleotide dependent protein kinases on the endoplasmic reticulum Ca2+ pump of bovine pulmonary artery

1990 • 84 citations

Cytochrome P-450-dependent monooxygenase activity and endothelial-dependent relaxations induced by arachidonic acid.

1986 • 77 citations

Possible ozone reductions and UV changes at the Earth's surface

1980 • 74 citations

Nature of Endothelium-Derived Relaxing Factor: Are There Two Relaxing Mediators?

1987 • 68 citations

Modulation of Endothelium-Dependent Hyperpolarization and Relaxation to Acetylcholine in Rat Mesenteric Artery by Cytochrome P450 Enzyme Activity

1996 • 58 citations

Inhibition of cytochrome P-450 reduces voltage-gated K+ currents in pulmonary arterial myocytes

1995 • 56 citations

Bioassay of Endothelium-Derived Hyperpolarizing Factor

1996 • 48 citations

Relaxant responses of rabbit aorta: influence of cytochrome P450 inhibitors.

1994 • 45 citations

15-lipoxygenase metabolites of arachidonic acid evoke contractions and relaxations in isolated canine arteries: role of thromboxane receptors, endothelial cells and cyclooxygenase.

1991 • 44 citations

Effect of the prostacyclin analogue iloprost on K+ permeability in the smooth muscle cells of the canine carotid artery.

1989 • 42 citations

Inhibition by zinc protoporphyrin‐IX of receptor‐mediated relaxation of the rat aorta in a manner distinct from inhibition of haem oxygenase

1995 • 40 citations

Evidence for mediation by endothelium‐derived hyperpolarizing factor of relaxation to bradykinin in the bovine isolated coronary artery independently of voltage‐operated Ca²⁺ channels

1996 • 38 citations

Mechanisms of L‐N^G nitroarginine/indomethacin‐resistant relaxation in bovine and porcine coronary arteries

1996 • 38 citations

Endothelium-derived hyperpolarizing factor: a key mediator of the vasodilator action of bradykinin

1996 • 32 citations

Bradykinin-Induced, Nω-Nitro-L-Arginine-Insensitive Endothelium-Dependent Relaxation of Porcine Coronary Arteries Is Not Mediated by Bioassayable Relaxing Substances

1992 • 30 citations

Myoendothelial Relations in the Conduit Coronary Artery of the Dog and Rabbit

1992 • 23 citations

Relationships between eicosanoids and cannabinoids

1995 • 21 citations

Thimerosal hyperpolarizes arterial smooth muscles in an endothelium-dependent manner

1990 • 18 citations