Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers

The herpes simplex virus amplicon: A new eucaryotic defective-virus cloning-amplifying vector

1982 • 507 citations

Regulation of α genes of herpes simplex virus: Expression of chimeric genes produced by fusion of thymidine kinase with α gene promoters

1981 • 449 citations

The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16

1989 • 434 citations

A Defective HSV-1 Vector Expresses Escherichia coli β-Galactosidase in Cultured Peripheral Neurons

1988 • 417 citations

Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation

1988 • 377 citations

A complex formed between cell components and an HSV structural polypeptide binds to a viral immediate early gene regulatory DNA sequence

1988 • 360 citations

Herpes simplex virus mutants defective in the virion-associated shutoff of host polypeptide synthesis and exhibiting abnormal synthesis of alpha (immediate early) viral polypeptides

1983 • 293 citations

Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells

1996 • 277 citations

The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein

1993 • 241 citations

An efficient deletion mutant packaging system for defective herpes simplex virus vectors: potential applications to human gene therapy and neuronal physiology.

1990 • 203 citations

Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effects of axotomy on sympathetic ganglia.

1992 • 203 citations

A Cosmid-Based System for Constructing Mutants of Herpes Simplex Virus Type 1

1993 • 200 citations

Herpes Simplex Virus Type 1 DNA Amplified as Bacterial Artificial Chromosome inEscherichia coli:Rescue of Replication-Competent Virus Progeny and Packaging of Amplicon Vectors

1998 • 198 citations

An Enhanced Packaging System for Helper-Dependent Herpes Simplex Virus Vectors

1998 • 183 citations

Periodic transcription of yeast histone genes

1982 • 160 citations

The virion transactivator of herpes simplex virus

1993 • 155 citations

Herpes simplex virus VP16 forms a complex with the virion host shutoff protein vhs

1994 • 151 citations

Herpes simplex virus VP16 rescues viral mRNA from destruction by the virion host shutoff function.

1996 • 131 citations

Pseudotransduction of hepatocytes by using concentrated pseudotyped vesicular stomatitis virus G glycoprotein (VSV-G)-Moloney murine leukemia virus-derived retrovirus vectors: comparison of VSV-G and amphotropic vectors for hepatic gene transfer

1996 • 121 citations

The octamer-binding protein Oct-2 represses HSV immediate-early genes in cell lines derived from latently infectable sensory neurons

1991 • 120 citations

A cellular factor binds to the herpes simplex virus type 1 transactivator Vmw65 and is required for Vmw65-dependent protein-DNA complex assembly with Oct-1.

1990 • 109 citations

Assembly of enveloped tegument structures (L particles) can occur independently of virion maturation in herpes simplex virus type 1-infected cells

1992 • 107 citations

Identification and characterization of the virion-induced host shutoff product of herpes simplex virus gene UL41

1992 • 103 citations

A steroid-inducible promoter for the controlled overexpression of cloned genes in eukaryotic cells.

1993 • 90 citations

Transfer of Contaminants in Adeno-Associated Virus Vector Stocks Can Mimic Transduction and Lead to Artifactual Results

1997 • 77 citations

The Virion Host Shutoff Function of Herpes Simplex Virus Degrades the 5′ End of a Target mRNA before the 3′ End

1999 • 74 citations

Hexamethylene bisacetamide stimulates herpes simplex virus immediate early gene expression in the absence of trans-induction by Vmw65

1992 • 70 citations

Herpes Simplex Virus Type 1 Amplicon Vectors with Glucocorticoid-Inducible Gene Expression

1995 • 60 citations

Differential effects of nerve growth factor and dexamethasone on herpes simplex virus type 1 oriL- and oriS-dependent DNA replication in PC12 cells

1997 • 56 citations

Identification and characterization of a small modular domain in the herpes simplex virus host shutoff protein sufficient for interaction with VP16

1996 • 39 citations

High efficiency in vitro gene transfer into vascular tissues using a pseudotyped retroviral vector without pseudotransduction

1999 • 30 citations

The Use of Defective Herpes Simplex Virus Amplicon Vectors to Modify Neural Cells and the Nervous System

1995 • 8 citations