Gene Transfer into the Nervous System using Recombinant Herpes Virus Vectors

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

1990 • 1,465 citations

A common progenitor for neurons and glia persists in rat retina late in development

1987 • 1,395 citations

Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

1991 • 994 citations

RNA Complementary to a Herpesvirus α Gene mRNA Is Prominent in Latently Infected Neurons

1987 • 902 citations

Mapping of Herpes Simplex Virus-1 Neurovirulence to γ ₁ 34.5, a Gene Nonessential for Growth in Culture

1990 • 705 citations

Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4

1985 • 702 citations

Neuron Specific Enolase, A Clinically Useful Marker for Neurons and Neuroendocrine Cells

1987 • 414 citations

Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.

1989 • 360 citations

Herpes simplex virus virion host shutoff function

1988 • 350 citations

A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency

1989 • 341 citations

Neurotropic properties of pseudorabies virus: uptake and transneuronal passage in the rat central nervous system

1990 • 337 citations

Herpes simplex virus latent phase transcription facilitates in vivo reactivation

1990 • 274 citations

A latent, nonpathogenic HSV-1-derived vector stably expresses β-galactosidase in mouse neurons

1990 • 264 citations

Herpes simplex virus type 1 latency-associated transcripts are evidently not essential for latent infection.

1989 • 246 citations

Identification of the latency-associated transcript promoter by expression of rabbit beta-globin mRNA in mouse sensory nerve ganglia latently infected with a recombinant herpes simplex virus

1989 • 237 citations

Herpes simplex virus type 1 ICP0 plays a critical role in the de novo synthesis of infectious virus following transfection of viral DNA

1989 • 237 citations

Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression

1989 • 232 citations

The Role of Herpes Simplex Virus Type 1 Thymidine Kinase in Pathogenesis

1989 • 226 citations

In Vivo Expression of β-Galactosidase in Hippocampal Neurons by HSV-Mediated Gene Transfer

1992 • 204 citations

Intracerebral grafting: A tool for the neurobiologist

1991 • 195 citations

Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants

1990 • 182 citations

Transneuronal Transfer of Herpes Virus from Peripheral Nerves to Cortex and Brainstem

1989 • 175 citations

A herpes simplex virus type 1 mutant containing a nontransinducing Vmw65 protein establishes latent infection in vivo in the absence of viral replication and reactivates efficiently from explanted trigeminal ganglia

1990 • 170 citations

Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse.

1989 • 167 citations

Retrovirus vectors and their applications in neurobiology

1988 • 162 citations

Herpes simplex virus for gene delivery to neurons.

1991 • 161 citations

Transfer and expression of the lacZ gene in rat brain neurons mediated by herpes simplex virus mutants.

1990 • 145 citations

Herpes simplex virus infection of the human sensory neuron

1988 • 145 citations

Uptake and Transport of Herpes Simplex Virus in Neurites of Rat Dorsal Root Ganglia Cells in Culture

1984 • 140 citations

Latent herpes simplex virus type 1 transcripts in peripheral and central nervous system tissues of mice map to similar regions of the viral genome

1988 • 140 citations

The herpes simplex virus virion host shutoff function

1989 • 137 citations

Genetic Engineering of Novel Genomes of Large DNA Viruses

1985 • 125 citations

Mapping bovine herpesvirus type 1 latency-related RNA in trigeminal ganglia of latently infected rabbits

1987 • 119 citations

β-galactosidase as a marker in the peripheral and neural tissues of the herpes simplex virus-infected mouse

1988 • 116 citations

Octamer motif mediates transcriptional repression of HSV immediate-early genes and octamer-containing cellular promoters in neuronal cells

1990 • 109 citations

Gene Transfer into Mammalian Central Nervous System Using Herpes Virus Vectors: Extended Expression of Bacterial lacZ in Neurons Using the Neuron-Specific Enolase Promoter

1992 • 104 citations

Human herpesviruses: a consideration of the latent state.

1989 • 101 citations

Introduction of a foreign gene (Escherichia coli lacZ) into rat neostriatal neurons using herpes simplex virus mutants: A light and electron microscopic study

1992 • 70 citations

Restricted expression of herpes simplex virus lytic genes during establishment of latent infection by thymidine kinase-negative mutant viruses

1990 • 67 citations

Latent Characteristics of Selected Herpesviruses

1978 • 65 citations

Expression of the herpes simplex virus 1 alpha transinducing factor (VP16) does not induce reactivation of latent virus or prevent the establishment of latency in mice

1991 • 65 citations

Identification of three genes nonessential for growth in cell culture near the right terminus of the unique sequences of long component of herpes simplex virus 1

1990 • 53 citations

Short‐ and long‐term survival of large neurons in the excitotoxic lesioned rat caudate nucleus: A light and electron microscopic study

1989 • 42 citations

The use of a retroviral vector to identify foetal striatal neurones transplanted into the adult striatum

1990 • 22 citations

HSV (Type 1) infection of the trigeminal complex

1990 • 21 citations

A viable HSV-1 mutant deleted in two nonessential major glycoproteins

1989 • 7 citations