Increased Level of Intracellular MHC Class II Molecules in Murine Langerhans Cells Following In Vivo and In Vitro Administration of Contact Allergens

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.

1985 • 1,141 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

1980 • 850 citations

Cultured Human Langerhans Cells Resemble Lymphoid Dendritic Cells in Phenotype and Function

1989 • 376 citations

Cycling of cell-surface MHC glycoproteins through primaquine-sensitive intracellular compartments

1990 • 254 citations

Phenotypic and functional characteristics of in vivo-activated Langerhans cells.

1990 • 238 citations

Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain.

1990 • 214 citations

Human Epidermal Langerhans Cells Undergo Profound Morphologic and Phenotypical Changes During In Vitro Culture

1990 • 210 citations

Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture.

1991 • 158 citations

Enhanced antigen-presenting capacity of cultured Langerhans' cells is associated with markedly increased expression of Ia antigen.

1987 • 154 citations

Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens.

1990 • 149 citations

Antigen processing and intracellular Ia. Possible roles of endocytosis and protein synthesis in Ia function.

1989 • 122 citations

Quantitation of Surface Antigens on Cultured Murine Epidermal Langerhans Cells: Rapid and Selective Increase in the Level of Surface MHC Products

1988 • 103 citations

Competition for antigen presentation in living cells involves exchange of peptides bound by class II MHC molecules

1989 • 94 citations

Activation and expansion of hapten- and protein-specific T helper cells from nonsensitized mice.

1988 • 93 citations

Turnover of Ia-peptide complexes is facilitated in viable antigen-presenting cells: biosynthetic turnover of Ia vs. peptide exchange.

1989 • 87 citations

T helper cells grown with hapten‐modified cultured Langerhans' cells produce interleukin 4 and stimulate IgE production by B cells

1989 • 82 citations

Functional and ultrastructural evidence for intracellular formation of major histocompatibility complex class II-peptide complexes during antigen processing.

1990 • 81 citations

Mouse B lymphocyte specific endocytosis and recycling of MHC class II molecules.

1990 • 75 citations

MHC class II-restricted presentation of native protein antigen by B cells is inhibitable by cycloheximide and brefeldin A.

1990 • 61 citations

Different Cellular Reaction Patterns of Epidermal Langerhans Cells After Application of Contact Sensitizing, Toxic, and Tolerogenic Compounds. A Comparative Ultrastructural and Morphometric Time-Course Analysis

1987 • 52 citations

Contact Allergens Modulate the Expression of MHC Class II Molecules on Murine Epidermal Langerhans Cells by Endocytotic Mechanisms

1992 • 43 citations

Biochemical properties of MHC class II molecules endogenously synthesized and expressed by mouse Langerhans cells

1991 • 42 citations

Internalization and Acidification of Surface HLA-DR Molecules by Epidermal Langerhans Cells: A Paradigm for Antigen Processing

1990 • 39 citations

Endocytosis and recycling of MHC-encoded class II molecules by mouse B lymphocytes.

1990 • 24 citations