Spinal μ-Opioid Receptor-Expressing Dorsal Horn Neurons: Role in Nociception and Morphine Antinociception

Reexamination of the dorsal root projection to the spinal dorsal horn including observations on the differential termination of coarse and fine fibers

1979 • 465 citations

Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: behavioral evidence

1996 • 392 citations

Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: electrophysiological evidence

1996 • 267 citations

Inhibition of Neuropathic Pain by Selective Ablation of Brainstem Medullary Cells Expressing the μ-Opioid Receptor

2001 • 259 citations

Contribution of GIRK2-mediated postsynaptic signaling to opiate and α ₂ -adrenergic analgesia and analgesic sex differences

2002 • 199 citations

Postsynaptic Signaling via the μ-Opioid Receptor: Responses of Dorsal Horn Neurons to Exogenous Opioids and Noxious Stimulation

2000 • 149 citations

Selective reduction of second pain sensations by systemic morphine in humans

1986 • 136 citations

Spinal G-Protein-Gated K⁺Channels Formed by GIRK1 and GIRK2 Subunits Modulate Thermal Nociception and Contribute to Morphine Analgesia

2004 • 135 citations

Physiological evidence that the ‘interphase’ in the formalin test is due to active inhibition

1999 • 123 citations

Specificity of female and male sex hormones on excitatory and inhibitory phases of formalin-induced nociceptive responses

2005 • 121 citations

Inhibition by Spinal μ- and δ-Opioid Agonists of Afferent-Evoked Substance P Release

2005 • 118 citations

An operant assay of thermal pain in conscious, unrestrained rats

2000 • 111 citations

Opioid modulation of capsaicin-evoked release of substance P from rat spinal cord in vivo

1989 • 111 citations

Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways

2006 • 105 citations

Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones

2003 • 104 citations

Presynaptic localization of the carboxy-terminus epitopes of the μ opioid receptor splice variants MOR-1C and MOR-1D in the superficial laminae of the rat spinal cord

2001 • 81 citations

Intrathecal substance p–saporin attenuates operant escape from nociceptive thermal stimuli

2003 • 80 citations

Spinal Opioid Analgesia: How Critical Is the Regulation of Substance P Signaling?

1999 • 79 citations

Morphine Antinociceptive Potency on Chemical, Mechanical, and Thermal Nociceptive Tests in the Rat

2006 • 78 citations

Blocking μ opioid receptors in the spinal cord prevents the analgesic action by subsequent systemic opioids

2006 • 76 citations

μ Opiate receptor immunoreactivity in rat central nervous system

1996 • 71 citations

Mu and delta opioid receptor-like immunoreactivity in the cervical spinal cord of the rat after dorsal rhizotomy or neonatal capsaicin: an analysis of pre- and postsynaptic receptor distributions

2002 • 71 citations

Characteristics of dose-dependent antagonism by beta-funaltrexamine of the antinociceptive effects of intrathecal mu agonists.

1991 • 68 citations

Effects of systemic morphine on responses of primates to first or second pain sensations

1996 • 62 citations

Comparison of Operant Escape and Innate Reflex Responses to Nociceptive Skin Temperatures Produced by Heat and Cold Stimulation of Rats.

2004 • 60 citations

Low dose systemic morphine attenuates operant escape but facilitates innate reflex responses to thermal stimulation

2002 • 59 citations

Opioidergic inhibition of capsaicin-evoked release of glutamate from rat spinal dorsal horn slices

1995 • 58 citations

Anti-nociceptive effects of selectively destroying substance P receptor-expressing dorsal horn neurons using [Sar9,Met(O2)11]-substance P-saporin: Behavioral and anatomical analyses

2007 • 55 citations

Neurotoxicity of Intrathecally Administered Bupivacaine Involves the Posterior Roots/Posterior White Matter and Is Milder Than Lidocaine in Rats

2005 • 54 citations

Distinct Populations of Spinal Cord Lamina II Interneurons Expressing G-Protein-Gated Potassium Channels

2006 • 54 citations

Targeted toxins in pain

2003 • 46 citations

Dual ultrastructural localization of ?-opiate receptors and substance p in the dorsal horn

2000 • 45 citations

Resting and Evoked Spinal Substance P Release during Chronic Intrathecal Morphine Infusion: Parallels with Tolerance and Dependence

2005 • 41 citations

Spinal action of dermorphin, an extremely potent opioid peptide from frog skin

1986 • 40 citations

The effect of lesions of the dorsolateral funiculus on formalin pain and morphine analgesia: a dose-response analysis

1996 • 36 citations

Apparent insensitivity of the hotplate latency test for detection of antinociception following intraperitoneal, intravenous or intracerebroventricular M6G administration to rats.

1998 • 35 citations

The role of descending fibers from the rostral ventromedial medulla in opioid analgesia in rats

2002 • 35 citations

Differential antinociceptive effects of spinal opioids on foot withdrawal responses evoked by C fibre or Aδ nociceptor activation

1997 • 33 citations

[d-Ala2,N-MePhe4,Gly-ol5]enkephalin-induced internalization of the μ opioid receptor in the spinal cord of morphine tolerant rats

2004 • 33 citations

192 IgG-saporin

1995 • 33 citations

Role of μ-opioid receptors in formalin-induced pain behavior in mice

2003 • 31 citations

Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation

2005 • 25 citations

Endomorphin-2 axon terminals contact mu-opioid receptor-containing dendrites in trigeminal dorsal horn

2003 • 25 citations

Spinal amino acid release and repeated withdrawal in spinal morphine tolerant rats

2003 • 24 citations

192 IgG-saporin

1995 • 23 citations

Elimination of neurokinin-1 receptor neurons in caudal nucleus reverses the effects of systemic bicuculline on c-Fos expression in rat trigeminal sensory nucleus: I. High intensity electrical stimulation of the trigeminal ganglion

2005 • 15 citations

Superficial NK1 expressing spinal dorsal horn neurones modulate inhibitory neurotransmission mediated by spinal GABAA receptors

2007 • 13 citations

Expression of MOR_1C‐like μ‐opioid receptor mRNA in rats

2004 • 10 citations

Calcium Channel Modulators ModifyKOpioid-Induced Inhibition of C-Fiber-Evoked Spinal Reflexes in Rat

1993 • 7 citations

Saporin Conjugates and Pain

2007 • 1 citations

Cited By (0)

Loading...