Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress

Lessons From Sudden Coronary Death

2000 • 3,869 citations

Laminar Shear Stress

1998 • 1,052 citations

The role of shear stress in the pathogenesis of atherosclerosis

2004 • 1,044 citations

Endothelial Dysfunction, Hemodynamic Forces, and Atherogenesis^a

2000 • 828 citations

Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture.

1995 • 723 citations

Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature

2004 • 635 citations

Presence of Intraplaque Hemorrhage Stimulates Progression of Carotid Atherosclerotic Plaques

2005 • 552 citations

Oscillatory Shear Stress Stimulates Adhesion Molecule Expression in Cultured Human Endothelium

1998 • 534 citations

Role of Integrins in Endothelial Mechanosensing of Shear Stress

2002 • 526 citations

Effect of Endothelial Shear Stress on the Progression of Coronary Artery Disease, Vascular Remodeling, and In-Stent Restenosis in Humans

2003 • 430 citations

Blood flow and vascular gene expression: fluid shear stress as a modulator of endothelial phenotype

1999 • 384 citations

C-Reactive Protein Accelerates the Progression of Atherosclerosis in Apolipoprotein E–Deficient Mice

2004 • 380 citations

Advanced Atherosclerotic Lesions in the Innominate Artery of the ApoE Knockout Mouse

2000 • 378 citations

Angiotensin II–Induced Hypertension Accelerates the Development of Atherosclerosis in ApoE-Deficient Mice

2001 • 361 citations

Impact of Interleukin-6 on Plaque Development and Morphology in Experimental Atherosclerosis

2004 • 328 citations

Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique

2005 • 268 citations

Fluid shear stress modulates surface expression of adhesion molecules by endothelial cells

1995 • 208 citations

Induction of Atherosclerotic Plaque Rupture in Apolipoprotein E ^−/− Mice After Adenovirus-Mediated Transfer of p53

2002 • 197 citations

Atherosclerotic Plaque Rupture

2003 • 155 citations

Relation between non-uniform hemodynamics and sites of altered permeability and lesion growth at the rabbit aorto-celiac junction

1999 • 149 citations

Endogenous Angiotensin II Induces Atherosclerotic Plaque Vulnerability and Elicits a Th1 Response in ApoE ^−/− Mice

2004 • 132 citations

Acyl-CoA:Cholesterol Acyltransferase Inhibitor Avasimibe Reduces Atherosclerosis in Addition to Its Cholesterol-Lowering Effect in ApoE*3-Leiden Mice

2001 • 115 citations

Expression of CYR61, an Angiogenic Immediate Early Gene, in Arteriosclerosis and Its Regulation by Angiotensin II

2002 • 113 citations

Reduction of Blood Pressure, Plasma Cholesterol, and Atherosclerosis by Elevated Endothelial Nitric Oxide

2002 • 111 citations

Distribution of Early Atherosclerotic Lesions in the Human Abdominal Aorta Correlates with Wall Shear Stresses MeasuredIn Vivo

1999 • 106 citations

Regulation of low shear flow-induced HAEC VCAM-1 expression and monocyte adhesion

1999 • 103 citations

Expansive Arterial Remodeling Is Associated With Increased Neointimal Macrophage Foam Cell Content

2002 • 99 citations

The convergence of haemodynamics, genomics, and endothelial structure in studies of the focal origin of atherosclerosis

2002 • 94 citations

How to evaluate plaque vulnerability in animal models of atherosclerosis?

2002 • 80 citations

Chronic Exposure to the Carcinogenic Compound Benzo[a]Pyrene Induces Larger and Phenotypically Different Atherosclerotic Plaques in ApoE-Knockout Mice

2004 • 76 citations

Accelerated Atherosclerosis by Placement of a Perivascular Cuff and a Cholesterol-Rich Diet in ApoE*3Leiden Transgenic Mice

2000 • 75 citations

Shear-Stress and Wall-Stress Regulation of Vascular Remodeling After Balloon Angioplasty

2001 • 72 citations

The Role of Shear Stress in Atherosclerosis: Action Through Gene Expression and Inflammation?

2004 • 49 citations

Factors influencing the nonuniform localization of monocytes in the arterial wall

2002 • 3 citations