How to evaluate plaque vulnerability in animal models of atherosclerosis?

Lessons From Sudden Coronary Death

2000 • 3,869 citations

Coronary Plaque Disruption

1995 • 3,542 citations

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.

1994 • 2,497 citations

Plaque fissuring--the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina.

1985 • 2,003 citations

Evidence for Increased Collagenolysis by Interstitial Collagenases-1 and -3 in Vulnerable Human Atheromatous Plaques

1999 • 660 citations

Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells.

1998 • 646 citations

Changing concepts of atherogenesis

2000 • 625 citations

Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells.

1991 • 591 citations

Characterization of the relative thrombogenicity of atherosclerotic plaque components: Implications for consequences of plaque rupture

1994 • 575 citations

The Unstable Atheroma

1997 • 568 citations

Lipid Lowering by Diet Reduces Matrix Metalloproteinase Activity and Increases Collagen Content of Rabbit Atheroma

1998 • 565 citations

Macrophages and atherosclerotic plaque stability

1996 • 474 citations

Factors influencing the presence or absence of acute coronary artery thrombi in sudden ischaemic death

1989 • 396 citations

George Lyman Duff memorial lecture. Progression and regression of atherosclerotic lesions. Insights from lipid physical biochemistry.

1988 • 389 citations

Advanced Atherosclerotic Lesions in the Innominate Artery of the ApoE Knockout Mouse

2000 • 378 citations

Thermal detection of cellular infiltrates in living atherosclerotic plaques: possible implications for plaque rupture and thrombosis

1996 • 369 citations

Rous-Whipple Award Lecture. Atherosclerosis: a defense mechanism gone awry.

1993 • 352 citations

Apoptosis of vascular smooth muscle cells in vascular remodelling and atherosclerotic plaque rupture

1999 • 273 citations

Mechanical properties of model atherosclerotic lesion lipid pools.

1994 • 258 citations

Progression and Regression of Atherosclerotic Lesions

2002 • 237 citations

Atherosclerotic plaque rupture in the apolipoprotein E knockout mouse

2001 • 220 citations

Tissue Factor in the Pathogenesis of Atherosclerosis

1997 • 192 citations

Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice

1999 • 176 citations

Triggering of Plaque Disruption and Arterial Thrombosis in an Atherosclerotic Rabbit Model

1995 • 162 citations

Collagen types I and III, collagen content, GAGs and mechanical strength of human atherosclerotic plaque caps: span-wise variations

1992 • 159 citations

Dietary Lipid Lowering Reduces Tissue Factor Expression in Rabbit Atheroma

1999 • 144 citations

Development of complex atherosclerotic lesions in pigs with inherited hyper-LDL cholesterolemia bearing mutant alleles for apolipoprotein B.

1991 • 133 citations

Fibromuscular cap composition is important for the stability of established atherosclerotic plaques in mature WHHL rabbits treated with statins

2001 • 122 citations

Spontaneous combined hyperlipidemia, coronary heart disease and decreased survival in Dahl salt-sensitive hypertensive rats transgenic for human cholesteryl ester transfer protein

1999 • 121 citations

Hyperlipidemia Promotes Thrombosis After Injury to Atherosclerotic Vessels in Apolipoprotein E–Deficient Mice

2000 • 96 citations

Animal Model That Mimics Atherosclerotic Plaque Rupture

1998 • 85 citations

Hypercholesterolemia Causes Mechanical Weakening of Rabbit Atheroma

2000 • 82 citations

Rabbit arterial thrombosis production by systemic procedures.

1961 • 74 citations

Hirudin Reduces Tissue Factor Expression in Neointima After Balloon Injury in Rabbit Femoral and Porcine Coronary Arteries

1998 • 64 citations

Aortic atherosclerotic plaque injury in apolipoprotein E deficient mice

1998 • 54 citations

Mouse models of focal arterial and venous thrombosis

2000 • 34 citations

Aortic medial necrosis with or without thrombosis in rabbits treated with Russell's viper venom and angiotensin II

1997 • 23 citations

Deleted Work

1955 • 0 citations