Linomide, a novel immunomodulator that prevents death in four models of septic shock

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia.

1993 • 821 citations

Septic shock: pathogenesis

1991 • 743 citations

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

1991 • 675 citations

T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor.

1992 • 595 citations

The toxicity of staphylococcal enterotoxin B in mice is mediated by T cells.

1990 • 347 citations

Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor.

1988 • 295 citations

The p70 tumor necrosis factor receptor mediates cytotoxicity

1992 • 277 citations

Glucocorticoid-mediated control of the activation and clonal deletion of peripheral T cells in vivo.

1993 • 163 citations

Cytokine release syndrome induced by the 145-2C11 anti-CD3 monoclonal antibody in mice: prevention by high doses of methylprednisolone.

1991 • 99 citations

Septic shock: treatment

1991 • 77 citations

Expansion and clonal deletion of peripheral T cells induced by bacterial superantigen is independent of the interleukin‐2 pathway

1992 • 70 citations

The Effects of RU 486 on Immune Function and Steroid-Induced Immunosuppressionin Vitro*

1989 • 56 citations

Interferon‐α prevents endotoxin‐induced mortality in mice

1992 • 41 citations

The glucocorticoid antagonist RU38486 mimics interleukin‐1 in its sensitization to the lethal and interleukin‐6‐inducing properties of tumor necrosis factor

1992 • 32 citations

The effect of adrenalectomy on interleukin‐1 release in vitro and in vivo

1989 • 30 citations

ABOLITION OF THE EFFECT OF CYCLOSPORINE ON RAT CARDIAC ALLOGRAFT REJECTION BY THE NEW IMMUNOMODULATOR LS-2616 (LINOMIDE)

1989 • 28 citations

EVIDENCE THAT LS-2616 (LINOMIDE) CAUSES ACUTE REJECTION OF RAT ALLOGRAFTS PROTECTED BY CYCLOSPORINE BUT NOT OF LONG-TERM SURVIVING ALLOGRAFTS

1991 • 14 citations

Duration of antagonizing effect of RU486 on the agonist induction of tyrosine aminotransferase via glucocorticoid receptor

1992 • 7 citations