Differential development of acute tolerance to analgesia, respiratory depression, gastrointestinal transit and hormone release in a morphine infusion model

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

The Pharmacological Basis of Therapeutics

1986 • 2,365 citations

Simultaneous quantitative assessment of morphine tolerance and physical dependence.

1969 • 681 citations

Classification of multiple morphine and enkephalin binding sites in the central nervous system.

1981 • 372 citations

Minireview: Multiple MU opiate receptors

1986 • 348 citations

Narcotic Drugs—Biochemical Pharmacology

1972 • 310 citations

Separation of opioid analgesia from respiratory depression: evidence for different receptor mechanisms.

1985 • 271 citations

Physiological parameters of morphine dependence in man—Tolerance, early abstinence, protracted abstinence

1969 • 264 citations

Opiate Analgesia: Evidence for Mediation by a Subpopulation of Opiate Receptors

1980 • 249 citations

DEVELOPMENT AND LOSS OF TOLERANCE TO MORPHINE IN THE RAT AFTER SINGLE AND MULTIPLE INJECTIONS.

1964 • 200 citations

Naloxazone, a long-acting opiate antagonist: effects on analgesia in intact animals and on opiate receptor binding in vitro.

1980 • 170 citations

Irreversible opiate agonists and antagonists: the 14-hydroxydihydromorphinone azines.

1982 • 164 citations

Irreversible opiate agonists and antagonists: the 14- hydroxydihydromorphinone azines

1982 • 156 citations

Relative involvement of mu, kappa and delta receptor mechanisms in opiate-mediated antinociception in mice.

1983 • 153 citations

Multiple opiate receptors in peripheral tissue preparations

1981 • 150 citations

A General Theory of the Genesis of Drug Dependence by Induction of Receptors

1965 • 149 citations

A COMPARISON BETWEEN ACUTE AND CHRONIC PHYSICAL DEPENDENCE IN THE CHRONIC SPINAL DOG.

1964 • 130 citations

Dissociation of opioid antinociception and central gastrointestinal propulsion in the mouse: studies with naloxonazine.

1988 • 126 citations

Separation of Morphine Analgesia from Physical Dependence

1984 • 126 citations

Role of μ1-opiate receptors in supraspinal opiate analgesia: a microinjection study

1988 • 119 citations

ACUTE TOLERANCE TO NARCOTIC ANALGESIC DRUGS IN RATS

1968 • 116 citations

Pharmacokinetics and pharmacodynamics of subcutaneous morphine pellets in the rat.

1985 • 96 citations

Prolactin and Growth Hormone Release by Morphine in the Rat: Different Receptor Mechanisms

1982 • 93 citations

Relative involvement of receptor subtypes in opioid-induced inhibition of gastrointestinal transit in mice.

1983 • 80 citations

Demonstration of tolerance and physical dependence in the dog following a short-term infusion of morphine.

1961 • 77 citations

The phenomena of tolerance

1953 • 68 citations

Functional opiate receptors in the guinea-pig ileum: their differentiation by means of selective tolerance development.

1981 • 65 citations

Lack of cross-tolerance on multiple opiate receptors in the mouse vas deferens.

1980 • 62 citations

Differential blockade by naloxonazine of two μ opiate actions: Analgesia and inhibition of gastrointestinal transit

1988 • 61 citations

Mu opiate isoreceptors: Differentiation with kappa agonists

1982 • 60 citations

Autoradiographic evidence for two classes of mu opioid binding sites in rat brain using [125I]FK33824

1987 • 58 citations

A very high affinity opioid binding site in rat brain: Demonstration by computer modeling

1984 • 54 citations

Diseases of the nervous system. Clinical neurobiology

1987 • 54 citations

THE OFFSET OF MORPHINE TOLERANCE IN RATS AND MICE

1975 • 45 citations

Two new methods for pharmacological comparison of insoluble purgatives**From the Laboratory for Organic Chemistry, Johns Hopkins University, and the Pharmacological Research Laboratory, Hynson, Westcott & Dunning, Inc., Baltimore, Maryland.

1931 • 41 citations

MU1: A very high affinity subtype of enkephalin binding sites in rat brain

1985 • 38 citations

Development of tolerance to respiratory depression in morphine- and etorphine-pellet-implanted mice

1987 • 26 citations

Methadone induced physical dependence in the rat

1984 • 22 citations

Irreversible opiate agonists and antagonists. II. Evidence against a bivalent mechanism of action for opiate azines and diacylhydrazones.

1985 • 21 citations

The use of computer analysis in describing multiple opiate receptors

1984 • 18 citations

Is There a Common, High-Affinity Opioid Binding Site in Rat Brain?

1986 • 15 citations

Sites of acute morphine tolerance in intestine.

1974 • 12 citations

Tolerance and cross-tolerance to the antisecretory effects of enkephalins on the guinea-pig ileal mucosa.

1985 • 6 citations