COMT Val108/158Met Modifies Mismatch Negativity and Cognitive Function in 22q11 Deletion Syndrome

The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions

2003 • 5,516 citations

Effect of COMT Val ^108/158 Met genotype on frontal lobe function and risk for schizophrenia

2001 • 2,408 citations

22q11.2 deletion syndrome

2015 • 2,036 citations

Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain

2004 • 1,637 citations

Spectrum of clinical features associated with interstitial chromosome 22q11 deletions: a European collaborative study.

1997 • 1,187 citations

Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia

2003 • 1,160 citations

High Rates of Schizophrenia in Adults With Velo-Cardio-Facial Syndrome

1999 • 1,013 citations

Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice

2001 • 996 citations

The Child and Adolescent Psychiatric Assessment (CAPA)

1995 • 968 citations

Catechol O -methyltransferase val ¹⁵⁸ -met genotype and individual variation in the brain response to amphetamine

2003 • 900 citations

‘Primitive intelligence’ in the auditory cortex

2001 • 819 citations

D1 receptors in prefrontal cells and circuits

2000 • 804 citations

Prefrontal neurons and the genetics of schizophrenia

2001 • 738 citations

The Development of Working Memory in Normally Achieving and Subtypes of Learning Disabled Children

1989 • 734 citations

Schizophrenia and Affective Disorders—Cosegregation with a Translocation at Chromosome 1q42 That Directly Disrupts Brain-Expressed Genes: Clinical and P300 Findings in a Family

2001 • 729 citations

Mismatch negativity in schizophrenia: a meta-analysis

2005 • 702 citations

A Highly Significant Association between a COMT Haplotype and Schizophrenia

2002 • 701 citations

Role of cortical N-methyl-D-aspartate receptors in auditory sensory memory and mismatch negativity generation: implications for schizophrenia.

1996 • 647 citations

A Functional Polymorphism in the COMT Gene and Performance on a Test of Prefrontal Cognition

2002 • 613 citations

Genes, dopamine and cortical signal-to-noise ratio in schizophrenia

2004 • 596 citations

Executive Subprocesses in Working Memory

2003 • 591 citations

The Quick Test (QT): Provisional Manual,

1962 • 578 citations

The Development of Working Memory in Normally Achieving and Subtypes of Learning Disabled Children

1989 • 577 citations

Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder

2003 • 573 citations

Attention, Memory, and Motor Skills as Childhood Predictors of Schizophrenia-Related Psychoses: The New York High-Risk Project

2000 • 507 citations

The 22q11 deletion syndromes

2000 • 492 citations

Association of Promoter Variants in the α7 Nicotinic Acetylcholine Receptor Subunit Gene With an Inhibitory Deficit Found in Schizophrenia

2002 • 446 citations

Psychotic Illness in Patients Diagnosed with Velo-Cardio-Facial Syndrome and Their Relatives

1994 • 434 citations

Mismatch negativity: An index of a preattentive processing deficit in schizophrenia

1991 • 408 citations

Brain potential evidence for an auditory sensory memory deficit in schizophrenia

1995 • 362 citations

Association Between a Functional Catechol O-Methyltransferase Gene Polymorphism and Schizophrenia: Meta-Analysis of Case-Control and Family-Based Studies

2003 • 348 citations

Premorbid Social Functioning in Schizophrenia and Bipolar Disorder: Similarities and Differences

1997 • 337 citations

The Schizophrenia Phenotype in 22q11 Deletion Syndrome

2003 • 329 citations

Neurocognitive correlates of the COMT Val158Met polymorphism in chronic schizophrenia

2002 • 327 citations

Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia

2002 • 322 citations

Catechol-O-Methyltransferase Genotype and Dopamine Regulation in the Human Brain

2003 • 321 citations

Impaired auditory frequency discrimination in dyslexia detected with mismatch evoked potentials

1999 • 319 citations

Mismatch negativity potentials and cognitive impairment in schizophrenia

2003 • 314 citations

Speech Disorder in Schizophrenia: Review of the Literature and Exploration of Its Relation to the Uniquely Human Capacity for Language

2001 • 312 citations

Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia

2004 • 310 citations

Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome

1996 • 308 citations

Mismatch Negativity in Chronic Schizophrenia and First-Episode Schizophrenia

2002 • 285 citations

Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder

2003 • 272 citations

Associated deficits in mismatch negativity generation and tone matching in schizophrenia

2000 • 253 citations

Inheritance of low erythrocyte catechol-o-methyltransferase activity in man.

1977 • 248 citations

How specific are deficits in mismatch negativity generation to schizophrenia?

2003 • 244 citations

Catechol O-Methyltransferase Val¹⁵⁸Met Polymorphism in Schizophrenia: Differential Effects of Val and Met Alleles on Cognitive Stability and Flexibility

2004 • 232 citations

Deficits in Auditory and Visual Context-Dependent Processing in Schizophrenia

2000 • 230 citations

The Neurocognitive Phenotype of the 22Q11.2 Deletion Syndrome: Selective Deficit in Visual-Spatial Memory

2001 • 222 citations

The behavioural phenotype in velo-cardio-facial syndrome (VCFS): from infancy to adolescence.

1999 • 205 citations

Cognition in schizophrenia

2001 • 187 citations

Duration mismatch negativity in biological relatives of patients with schizophrenia spectrum disorders

2002 • 186 citations

Neuropsychological change in young people at high risk for schizophrenia: results from the first two neuropsychological assessments of the Edinburgh High Risk Study

2000 • 184 citations

Duration and frequency mismatch negativity in schizophrenia

2000 • 180 citations

Association of the G1947A COMT (Val108/158Met) gene polymorphism with prefrontal P300 during information processing

2003 • 173 citations

Adolescents and young adults with 22qll deletion syndrome: psychopathology in an at-risk group

2005 • 170 citations

COMT: A common susceptibility gene in bipolar disorder and schizophrenia

2004 • 165 citations

Obsessive‐compulsive disorder in patients with velocardiofacial (22q11 deletion) syndrome

2003 • 154 citations

Cognition in schizophrenia : impairments, importance, and treatment strategies

2000 • 146 citations

Mismatch Negativity Event-Related Potential Elicited by Speech Stimuli

1992 • 139 citations

Subjective and objective neuropsychological abnormalities in a psychosis prodrome clinic

2002 • 138 citations

Effects of a Functional COMT Polymorphism on Prefrontal Cognitive Function in Patients With 22q11.2 Deletion Syndrome

2004 • 131 citations

Impairment in frontal but not temporal components of mismatch negativity in schizophrenia

2002 • 130 citations

Individual differences in spatial working memory in relation to schizotypy.

1995 • 130 citations

Impaired Cortical Network for Preattentive Detection of Change in Speech Sounds in Schizophrenia: A High-Resolution Event-Related Potential Study

2002 • 125 citations

THE QUICK TEST

1951 • 124 citations

Comparison of three WISC-III short forms: Weighing psychometric, clinical, and practical factors

1996 • 123 citations

Velo-cardio-facial syndrome

2005 • 123 citations

An investigation of the neuropsychological profile in adults with velo-cardio-facial syndrome (VCFS)

2002 • 116 citations

Velo‐cardio‐facial syndrome: Implications of microdeletion 22q11 for schizophrenia and mood disorders

2001 • 116 citations

Individual differences in spatial working memory in relation to schizotypy.

1995 • 110 citations

Automatic processing of tones and speech stimuli in children with specific language impairment

2002 • 108 citations

Association between reduced duration mismatch negativity (MMN) and raised temporal discrimination thresholds in schizophrenia

2003 • 106 citations

Event-related potential correlates of impaired selective attention in children at high risk for schizophrenia

1992 • 102 citations

Automatic processing of tones and speech stimuli in children with specific language impairment

2002 • 100 citations

Performance of patients with schizophrenia on a pen and paper visuospatial working memory task with short delay

1997 • 96 citations

Impairment in activation of a frontal attention-switch mechanism in schizophrenic patients

2002 • 89 citations

Genetic linkage and association between chromosome 1q and working memory function in schizophrenia

2002 • 88 citations

Language skills in children with velocardiofacial syndrome (deletion 22q11.2)

2002 • 88 citations

The methionine allele of the COMT polymorphism impairs prefrontal cognition in children and adolescents with ADHD

2005 • 87 citations

Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia

2004 • 83 citations

Auditory sensory memory in schizophrenia: inadequate trace formation?

2000 • 75 citations

Selectivity of verbal memory deficit in schizophrenic patients and their relatives

2002 • 74 citations

The difference in Mismatch negativity between the acute and post-acute phase of schizophrenia

2002 • 73 citations

Catecholamines in patients with 22q11.2 deletion syndrome and the low-activity COMT polymorphism

2001 • 68 citations

The first neurophysiological evidence for cognitive brain dysfunctions in children with CATCH

1997 • 60 citations

Short‐forms of the UK WAIS—R: Regression equations and their predictive validity in a general population sample

1992 • 59 citations

language comprehension in schizophrenics and their brothers

1992 • 56 citations

Analysis of Speech Characteristics in Children With Velocardiofacial Syndrome (VCFS) and Children With Phenotypic Overlap Without VCFS

2001 • 53 citations

Schizotypy and patterns of lateral asymmetry on hemisphere-specific language tasks

2001 • 45 citations

Profiles of communication disorder in children with velocardiofacial syndrome: Comparison to children with Down syndrome

2001 • 37 citations

The neurocognitive phenotype of the 22Q11.2 deletion syndrome

1999 • 2 citations