Binding site of brefeldin A at the interface between the small G protein ADP-ribosylation factor 1 (ARF1) and the nucleotide-exchange factor Sec7 domain

Structure and Mechanism in Protein Science

1998 • 1,918 citations

The structural basis of the activation of Ras by Sos

1998 • 765 citations

Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein

1992 • 741 citations

Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF

1992 • 736 citations

Structural Basis for Activation of ARF GTPase

1998 • 534 citations

Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors

2000 • 468 citations

A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains

1996 • 465 citations

Brefeldin A Acts to Stabilize an Abortive ARF–GDP–Sec7 Domain Protein Complex

1999 • 441 citations

Kinetics of interaction of nucleotides with nucleotide-free H-ras p21

1990 • 410 citations

Brefeldin A

1999 • 385 citations

Active Transcriptional Repression by the Rb–E2F Complex Mediates G1 Arrest Triggered by p16INK4a, TGFβ, and Contact Inhibition

1999 • 355 citations

GEFs: structural basis for their activation of small GTP-binding proteins

1999 • 334 citations

Structure of the human ADP-ribosylation factor 1 complexed with GDP

1994 • 284 citations

Nucleotide exchange on ARF mediated by yeast Geal protein

1996 • 271 citations

The Kinetic Mechanism of Ran-Nucleotide Exchange Catalyzed by RCC1

1995 • 224 citations

Kinetic Analysis by Fluorescence of the Interaction between Ras and the Catalytic Domain of the Guanine Nucleotide Exchange Factor Cdc25^Mm

1998 • 221 citations

Structure of the Guanine Nucleotide Exchange Factor Sec7 Domain of Human Arno and Analysis of the Interaction with ARF GTPase

1998 • 184 citations

Structure of the Sec7 domain of the Arf exchange factor ARNO

1998 • 183 citations

A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta -phosphate to destabilize GDP on ARF1

1998 • 180 citations

Role of Protein-Phospholipid Interactions in the Activation of ARF1 by the Guanine Nucleotide Exchange Factor Arno

1997 • 169 citations

p200 ARF–GEP1: A Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A

1999 • 121 citations

The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms

1995 • 105 citations

Cloning and expression of a cDNA encoding a bovine brain brefeldin A-sensitive guanine nucleotide-exchange protein for ADP-ribosylation factor

1997 • 104 citations

Brefeldin A-inhibited guanine nucleotide-exchange activity of Sec7 domain from yeast Sec7 with yeast and mammalian ADP ribosylation factors

1998 • 94 citations

Invasion of the Nucleotide Snatchers

1998 • 74 citations

Dual Interaction of ADP Ribosylation Factor 1 with Sec7 Domain and with Lipid Membranes during Catalysis of Guanine Nucleotide Exchange

1999 • 71 citations

Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors

1999 • 67 citations

Solution structure of the cytohesin-1 (B2–1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1

1998 • 39 citations