Behavioral and physiological responses to anabolic-androgenic steroids

The Physiology of Reproduction

1988 • 7,765 citations

How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions*

2000 • 6,211 citations

How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions

2000 • 4,657 citations

Hormones, Brain and Behavior

2009 • 1,548 citations

Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes.

1995 • 1,277 citations

Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications

1995 • 1,267 citations

GABA_A‐receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits

1995 • 1,219 citations

Altered nociception, analgesia and aggression in mice lacking the receptor for substance P

1998 • 757 citations

Functional Cross‐Talk Between the Hypothalamic‐Pituitary‐Gonadal and ‐Adrenal Axes

2002 • 714 citations

Neurosteroids and GABAA receptor function

1995 • 705 citations

Tonic Synaptic Inhibition Modulates Neuronal Output Pattern and Spatiotemporal Synaptic Integration

1997 • 639 citations

An update on GABAA receptors

1999 • 630 citations

Biological Aromatization of Steroids

1959 • 596 citations

Neurogenesis in Adult Mammals: Some Progress and Problems

2002 • 509 citations

Immunohistochemical Localization of the Androgen Receptor in Rat and Human Tissues*

1990 • 492 citations

Roles of Estrogen Receptor-α Gene Expression in Reproduction-Related Behaviors in Female Mice**This work was supported by the Harry Frank Guggenheim Foundation (to S.O.), the University of Missouri-Columbia molecular biology program (to D.B.L.), and NIH Grant HD-05751 (to D.W.P.).

1998 • 483 citations

Vasopressin/Serotonin Interactions in the Anterior Hypothalamus Control Aggressive Behavior in Golden Hamsters

1997 • 483 citations

Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action.

1988 • 459 citations

Hormonal doping and androgenization of athletes: a secret program of the German Democratic Republic government

1997 • 456 citations

Novel Mechanisms of Estrogen Action in the Brain: New Players in an Old Story

1999 • 434 citations

Androgen Abuse by Athletes

1988 • 433 citations

A review of the chemistry, biological action, and clinical applications of anabolic-androgenic steroids

2001 • 430 citations

Neuropharmacology of brain-stimulation-evoked aggression

1999 • 374 citations

Male Sexual Behavior

2009 • 370 citations

Neurobiology of Addiction: Toward the Development of New Therapies

2000 • 324 citations

Anabolic-Androgenic Steroid Use in the United States

1993 • 321 citations

Testosterone Rapidly Reduces Anxiety in Male House Mice (Mus musculus)

2002 • 301 citations

Synthesis, metabolism, and pharmacological activity of 3.alpha.-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes

1990 • 295 citations

Estrogen Regulates the Development of Brain-Derived Neurotrophic Factor mRNA and Protein in the Rat Hippocampus

2002 • 282 citations

The Rat Androgen Receptor: Primary Structure, Autoregulation of its Messenger Ribonucleic Acid, and Immunocytochemical Localization of the Receptor Protein

1988 • 277 citations

BDNF Mediates the Effects of Testosterone on the Survival of New Neurons in an Adult Brain

1999 • 267 citations

Steroid anesthetics and naturally occurring analogs modulate the gamma-aminobutyric acid receptor complex at a site distinct from barbiturates.

1989 • 266 citations

Genetic Variation in Susceptibility to Endocrine Disruption by Estrogen in Mice

1999 • 263 citations

The 5α-Reduction of Testosterone in the Neuroendocrine Structures. Biochemical and Physiological Implications*

1982 • 259 citations

Estrogens: Trophic and Protective Factors in the Adult Brain

2001 • 232 citations

Drugs of Abuse and the Brain

1999 • 224 citations

Anabolic-Androgenic Steroid Therapy in the Treatment of Chronic Diseases

2001 • 220 citations

Neurosteroids and GABA, receptor function

1995 • 210 citations

Anabolic steroids in sport and exercise

1993 • 210 citations

Drugs of abuse and immediate-early genes in the forebrain

1998 • 198 citations

Psychiatric and Medical Effects of Anabolic-Androgenic Steroid Use in Women

1999 • 198 citations

Treatment with an Anabolic-Androgenic Steroid Affects Anxiety-Related Behavior and Alters the Sensitivity of Cortical GABAA Receptors in the Rat

1993 • 192 citations

Anabolic steroid abuse and dependence

2002 • 181 citations

Neurosteroid Prolongs GABA_AChannel Deactivation by Altering Kinetics of Desensitized States

1997 • 173 citations

Endocrine aspects of anabolic steroids

1997 • 171 citations

Anabolic Steroids

2002 • 161 citations

Neurotrophin receptors: mediators of life and death

1998 • 161 citations

Gonadal influence on agonistic behavior in the male domestic rat

1972 • 158 citations

Testosterone has rewarding affective properties in male rats: Implications for the biological basis of sexual motivation.

1994 • 153 citations

Roles of Estrogen Receptor- Gene Expression in Reproduction-Related Behaviors in Female Mice

1998 • 146 citations

Feminine Sexual Behavior

2002 • 145 citations

Estrogen regulation of GABAA receptor subunit mRNA expression in preoptic area and bed nucleus of the stria terminalis of female rat brain

1995 • 133 citations

Current perspectives on anabolic-androgenic steroid abuse

1993 • 131 citations

Mapping Genes that Modulate Mouse Brain Development: A Quantitative Genetic Approach

2000 • 129 citations

Trends in Anabolic-Androgenic Steroid Use Among Adolescents

1997 • 129 citations

Serotonin regulation of aggressive behavior in male golden hamsters (Mesocricetus auratus).

1999 • 128 citations

Anabolic-Androgenic Steroid Abuse and Performance-Enhancing Drugs Among Adolescents

1998 • 123 citations

Testosterone has rewarding affective properties in male rats: Implications for the biological basis of sexual motivation.

1994 • 120 citations

Anabolic-Androgenic Steroid Exposure During Adolescence and Aggressive Behavior in Golden Hamsters

1997 • 119 citations

GABAergic control of masculine sexual behavior

1986 • 119 citations

Hormonal and neurochemical correlates of various forms of animal “aggression”

1992 • 117 citations

Up-regulation of androgen receptor immunoreactivity in the rat brain by androgenic-anabolic steroids

1993 • 116 citations

Response of serum hormones to androgen administration in power athletes

1985 • 115 citations

Psychological and Behavioural Effects of Endogenous Testosterone and Anabolic-Androgenic Steroids An Update

1996 • 109 citations

Chronic anabolic-androgenic steroid treatment during adolescence increases anterior hypothalamic vasopressin and aggression in intact hamsters

2000 • 109 citations

Increased dopaminergic and 5‐hydroxytryptaminergic activities in male rat brain following long‐term treatment with anabolic androgenic steroids

1999 • 106 citations

Double duty for sex differences in the brain

1998 • 106 citations

Aggression in Male Rats Receiving Anabolic Androgenic Steroids: Effects of Social and Environmental Provocation

2001 • 104 citations

Effects of chronically high doses of the anabolic androgenic steroid, testosterone, on intermale aggression and sexual behavior in male rats

1994 • 102 citations

Behavioural effects of androgen in men and women

2001 • 100 citations

Functional Significance of Steroid Modulation of GABAergic Neurotransmission: Analysis at the Behavioral, Cellular, and Molecular Levels

1995 • 100 citations

Serotonergic control of androgen-induced dominance

1994 • 99 citations

Metabolism of stanozolol: Identification and synthesis of urinary metabolites

1990 • 96 citations

Serotonin modulates offensive attack in adolescent anabolic steroid-treated hamsters

2002 • 94 citations

Anabolic androgenic steroids affects alcohol intake, defensive behaviors and brain opioid peptides in the rat

2000 • 91 citations

Anabolic androgenic steroids increase β-endorphin levels in the ventral tegmental area in the male rat brain

1997 • 90 citations

The testosterone metabolite and neurosteroid 3α-androstanediol may mediate the effects of testosterone on conditioned place preference

2001 • 90 citations

Modulation of short term and long term memory by steroid sexual hormones

1995 • 86 citations

High-dose anabolic androgenic steroids modulate concentrations of nerve growth factor and expression of its low affinity receptor (p75-NGFr) in male rat brain

1997 • 86 citations

Effects of an anabolic-androgenic steroid on the regulation of the NMDA receptor NR1, NR2A and NR2B subunit mRNAs in brain regions of the male rat

1997 • 84 citations

The anabolic‐androgenic steroid nandrolone decanoate affects the density of dopamine receptors in the male rat brain

2001 • 84 citations

Repeated Anabolic-Androgenic Steroid Treatment during Adolescence Increases Vasopressin V1A Receptor Binding in Syrian Hamsters: Correlation with Offensive Aggression

2002 • 83 citations

Selective increase of offensive behavior in the rat following intrahypothalamic 5,7-DHT-induced serotonin depletion

1988 • 80 citations

The Effect of Anabolic-Androgenic Steroids on Sexual Behavior and Reproductive Tissues in Male Rats

1997 • 79 citations

High doses of testosterone increase anticonflict behaviour in rat

1998 • 76 citations

GABA Physiology: Modulation by Benzodiazepines and Hormones

1996 • 76 citations

Anabolic androgenic steroid affects competitive behaviour, behavioural response to ethanol and brain serotonin levels

2002 • 74 citations

Sedative and anxiolytic effects of zopiclone's enantiomers and metabolite

2001 • 73 citations

Modulation of the GABA_A receptor complex by steroids in slices of rat cuneate nucleus

1989 • 71 citations

The effect on opioid peptides in the rat brain, after chronic treatment with the anabolic androgenic steroid, nandrolone decanoate

2000 • 71 citations

CNS Effects and Abuse Liability of Anabolic-Androgenic Steroids

1996 • 69 citations

Anabolic-androgenic steroid and adrenal steroid effects on hippocampal plasticity

1995 • 68 citations

Oral Testosterone Self-Administration in Male Hamsters

2001 • 68 citations

Anabolic-androgenic steroids and aggression in castrated male rats

1994 • 66 citations

Anabolic-androgenic steroid use in the United States

1993 • 66 citations

Anabolic–Androgenic Steroid Effects on the Sexual Behavior of Intact Male Rats

1997 • 66 citations

Physical Provocation Potentiates Aggression in Male Rats Receiving Anabolic Androgenic Steroids

2002 • 65 citations

The testosterone metabolite and neurosteroid 3α-androstanediol may mediate the effects of testosterone on conditioned place preference

2001 • 64 citations

The effect of anabolic–androgenic steroids on aromatase activity and androgen receptor binding in the rat preoptic area

1998 • 64 citations

Effects of prolonged exposure to anabolic steroids on the behavior of male and female mice

1996 • 64 citations

The effects of cocaine and nandrolone co-administration on aggression in male rats

1996 • 64 citations

STEROIDS AND STEROID-LIKE COMPOUNDS

1999 • 61 citations

Effects of castration and home cage residency on aggressive behavior in rats

1979 • 58 citations

Anabolic androgenic steroids induce age-, sex-, and dose-dependent changes in GABAA receptor subunit mRNAs in the mouse forebrain

2002 • 58 citations

Mouse models of serotonin receptor function: toward a genetic dissection of serotonin systems

2000 • 57 citations

Anabolic-androgenic steroids and brain reward

1996 • 57 citations

Dihydrotestosterone and estrogen regulation of rat brain androgen-receptor immunoreactivity

2000 • 56 citations

Behavioral effects of long-term administration of an anabolic steroid in intact and castrated male Wistar rats

1993 • 54 citations

Chronic anabolic-androgenic steroid treatment affects brain gabaa receptor-gated chloride ion transport

1996 • 53 citations

Anabolic Steroids Induce Region- and Subunit-Specific Rapid Modulation of GABA_AReceptor-Mediated Currents in the Rat Forebrain

2000 • 53 citations

Oral Testosterone Self-Administration in Male Hamsters: Dose-Response, Voluntary Exercise, and Individual Differences

2002 • 52 citations

Effect of anabolic steroids on behavior and physiological characteristics of female mice

1996 • 51 citations

ANABOLIC AGENTS

1998 • 51 citations

Anabolic-androgenic steroid induced alterations in choline acetyltransferase messenger RNA levels of spinal cord motoneurons in the male rat

1997 • 50 citations

Anabolic-androgenic steroids affect the content of substance P and substance P1–7 in the rat brain

2000 • 49 citations

The Effects of 17α-Methyltestosterone, Methandrostenolone, and Nandrolone Decanoate on the Rat Estrous Cycle

1997 • 47 citations

EFFECTS OF CHRONIC TREATMENT WITH TESTOSTERONE PROPIONATE ON AGGRESSION AND HORMONAL LEVELS IN INTACT MALE MICE

1998 • 47 citations

Comparison of the effects of 17 α-methyltestosterone, methandrostenolone, and nandrolone decanoate on the sexual behavior of castrated male rats.

1996 • 46 citations

THE METABOLISM OF [1,2-3H]17α-METHYLTESTOSTERONE IN HUMAN SUBJECTS

1967 • 46 citations

Direct effects of the anabolic/androgenic steroids, stanozolol and 17α-methyltestosterone, on benzodiazepine binding to the γ-aminobutyric acidA receptor

1995 • 46 citations

Inhibition of Estrogen-Induced Sexual Receptivity by Androgens: Role of the Androgen Receptor

1998 • 43 citations

Neurosteroid modulation of recombinant and synaptic GABAA receptors

2001 • 43 citations

Effects of withdrawal from anabolic androgenic steroids on aggression in adult male rats

2002 • 43 citations

Neurosteroid Effects in the Central Nervous System

2003 • 42 citations

Effects of the androgenic anabolic steroid, nandrolone decanoate, on adrenocorticotropin hormone, corticosterone and proopiomelanocortin, corticotropin releasing factor (CRF) and CRF receptor1 mRNA levels in the hypothalamus, pituitary and amygdala of the rat

2000 • 41 citations

Mechanisms of anabolic androgenic steroid modulation of α1β3γ2L GABAA receptors

2002 • 41 citations

Reversal of testosterone-induced dominance by the serotonergic agonist quipazine

1992 • 40 citations

Hormonal modulation of extinction responses induced by sexual steroid hormones in rats

1994 • 40 citations

Stanozolol, Oxymetholone, and Testosterone Cypionate Effects on the Rat Estrous Cycle

1998 • 38 citations

Dopaminergic effects after chronic treatment with nandrolone visualized in rat brain by positron emission tomography

2002 • 38 citations

Androgens: Endocrine Physiology and Pharmacology

1990 • 38 citations

The influence of testosterone in the brain of the male rat on levels of serotonin (5-HT) and hydroxyindole-acetic acid (5-HIAA)

1985 • 37 citations

Comparison of the effects of 17 α–methyltestosterone, methandrostenolone, and nandrolone decanoate on the sexual behavior of castrated male rats.

1996 • 37 citations

Performance-enhancing: Substances and Their Use Among Adolescent Athletes

2002 • 37 citations

Adolescent Anabolic Steroid Use and Aggressive Behavior in Golden Hamsters

1996 • 36 citations

Hemodialysis increases the preference for salt in soup

1997 • 35 citations

Cocaine-induced locomotor activity is enhanced by exogenous testosterone

2002 • 34 citations

Long-term chronic treatment with stanozolol lacks significant effects on aggression and activity in young and adult male laboratory mice

1996 • 34 citations

Androgenic-anabolic steroids modify β-endorphin immunoreactivity in the rat brain

1995 • 34 citations

Androgen Treatment Decreases Estrogen Receptor Binding in the Ventromedial Nucleus of the Rat Brain: A Quantitative in Vitro Autoradiographic Analysis

1994 • 34 citations

Abuse liability of anabolic steroids and their possible role in the abuse of alcohol, morphine, and other substances.

1990 • 32 citations

Effects of the androgenic/anabolic steroid stanozolol on GABAA receptor function: GABA-stimulated 36Cl- influx and [35S] TBPS binding.

1996 • 31 citations

Olfaction, GABAergic neurotransmission in the olfactory bulb, and intermale aggression in mice: Modulation by steroids

1996 • 30 citations

Anabolic Steroids and Training

1986 • 30 citations

Regulation of glucocorticoid receptor immunoreactivity in the rat hippocampus by andronergic-anabolic steroids

1992 • 29 citations

Spatial working memory is preserved in rats treated with anabolic-androgenic steroids

1996 • 27 citations

The expression of GABAA receptor α2 subunit is upregulated by testosterone in rat cerebral cortex

1999 • 27 citations

Anabolic-Androgenic Steroid Effects on Sexual Receptivity in Ovariectomized Rats

1997 • 27 citations

Testosterone implantation reduces the motor effects of cocaine

1994 • 27 citations

Comparison of the effects of stanozolol, oxymetholone, and testosterone cypionate on the sexual behavior of castrated male rats.

1997 • 23 citations

Action of Androgenic Steroids on Brain Neurotransmitters in Rats

1979 • 22 citations

Brain development and generation of brain pathologies

2001 • 21 citations

Androgenic–anabolic steroids blunt morphine-induced c-fos expression in the rat striatum: possible role of β-endorphin

2000 • 20 citations

Effect of combined treatment with nandrolone and cocaine on the NMDA receptor gene expression in the rat nucleus accumbens and periaqueductal gray

2002 • 19 citations

Anabolic steroids and behavior: a preclinical research prospectus.

1990 • 16 citations

Down-regulation of delta opioid receptor mRNA by an anabolic steroid in neuronal hybrid cells

2000 • 14 citations

Glucocorticoids and Anabolic/Androgenic Steroids Inhibit the Synthesis of GABAergic Steroids in Rat Cortex

1997 • 13 citations

Anabolic Androgenic Steroids and the Brain

2003 • 12 citations

The effects of drug abuse on the stress responsive hypothalamic–pituitary–adrenal axis and the dopaminergic and endogenous opioid systems

2002 • 9 citations

The effects of nandrolone decanoate on cocaine-induced kindling in male rats

2000 • 9 citations

Steroid abuse in female athletes.

1997 • 9 citations

Molecular Insights into Ion Channel Biology in Health and Disease

2004 • 8 citations

The behavioral and toxicological effects of testosterone pellet implantation

1987 • 7 citations

Steroid abuse in female athletes

1997 • 7 citations

Drug of abuse and neurobiology

1994 • 4 citations

Deleted Work

1955 • 0 citations