Molecular Recognition in Acetylcholinesterase Catalysis: Free-Energy Correlations for Substrate Turnover and Inhibition by Trifluoro Ketone Transition-State Analogs

A new and rapid colorimetric determination of acetylcholinesterase activity

1961 • 25,114 citations

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

Acetylcholinesterase: enzyme structure, reaction dynamics, and virtual transition states

1987 • 1,044 citations

Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.

1993 • 872 citations

Acetylcholine Binding by a Synthetic Receptor: Implications for Biological Recognition

1990 • 608 citations

Evolution of enzyme function and the development of catalytic efficiency

1976 • 604 citations

Tight-binding inhibitors—I

1975 • 497 citations

Perfection in enzyme catalysis: the energetics of triosephosphate isomerase

1977 • 359 citations

Fluoro ketone inhibitors of hydrolytic enzymes

1985 • 336 citations

Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket

1993 • 329 citations

Chemical achievement and hope for the future.

1948 • 318 citations

Amino acid residues controlling acetylcholinesterase and butyrylcholinesterase specificity

1993 • 311 citations

Molecular recognition in aqueous media. New binding studies provide further insights into the cation-.pi. interaction and related phenomena

1993 • 271 citations

Phosphonamidates as transition-state analog inhibitors of thermolysin

1983 • 265 citations

An electrostatic mechanism for substrate guidance down the aromatic gorge of acetylcholinesterase.

1993 • 253 citations

Catalysis, binding and enzyme-substrate complementarity

1974 • 222 citations

Effective charge on acetylcholinesterase active sites determined from the ionic strength dependence of association rate constants with cationic ligands

1980 • 189 citations

Use of peptide aldehydes to generate transition-state analogs of elastase

1973 • 181 citations

Acetylcholinesterase: electrostatic steering increases the rate of ligand binding

1993 • 144 citations

Expression of recombinant acetylcholinesterase in a baculovirus system: kinetic properties of glutamate 199 mutants

1992 • 136 citations

Fractional diffusion-limited component of reactions catalyzed by acetylcholinesterase

1986 • 133 citations

The Serological Properties of Simple Substances. IX. Hapten Inhibition of Precipitation of Antisera Homologous to the o-, m-, and p-Azophenylarsonic Acid Groups

1945 • 119 citations

Hydrolysis by acetylcholinesterase. Apparent molal volumes and trimethyl and methyl subsites.

1980 • 78 citations

Fluorinated aldehydes and ketones acting as quasi-substrate inhibitors of acetylcholinesterase

1979 • 73 citations

THE ACIDITY OF SOME AROMATIC FLUORO ALCOHOLS AND KETONES

1960 • 64 citations

Inhibition kinetics of acetylcholinesterase with fluoromethyl ketones

1989 • 63 citations

Kinetics of acetylthiocholine binding to electric eel acetylcholinesterase in glycerol/water solvents of increased viscosity Evidence for a diffusion-controlled reaction

1982 • 62 citations

m-(N,N,N-Trimethylammonio)trifluoroacetophenone: a femtomolar inhibitor of acetylcholinesterase

1993 • 47 citations

Conformational Aspects of Acetylcholine Receptor Sites. The Isomeric 3-Trimethylammonium-2-acetoxy-trans-decalin Halides¹ and the Isomeric α,β-Dimethylacetylcholine Halides²

1966 • 44 citations

Cationic and uncharged substrates and reversible inhibitors in hydrolysis by acetylcholinesterase (EC 3.1.1.7). The trimethyl subsite.

1981 • 38 citations

19F-NMR spectral evidence that 3-octylthio-1,1,1-trifluoropropan-2-one, a potent inhibitor of insect juvenile hormone esterase, functions as a transition state analog inhibitor of acetylcholinesterase

1988 • 38 citations

Parallel mechanisms in acetylcholinesterase-catalyzed hydrolysis of choline esters

1993 • 29 citations

Amino-substituted .alpha.,.alpha.,.alpha.-trifluoroacetophenones

1970 • 17 citations

Identification of the trypsin-like activity in commercial preparations of eel acetylcholinesterase

1991 • 16 citations

m-Alkyl, α,α,α-trifluoroacetophenones: A new class of potent transition state analog inhibitors of acetylcholinesterase

1993 • 15 citations

Conformational aspects of systems related to acetylcholine. 5. Syntheses of the dl-2(e)-methyl-, dl-3(e)-methyl-, and dl-2(e),3(e)-dimethyl-3(a)-trimethylammonium-2(a)-acetoxy-trans-decalin halides

1973 • 10 citations

A ketopentyl transition state analog for acetylcholinesterase

1976 • 9 citations

Conformational aspects of systems related to acetylcholine. 3. Base-catalyzed and acetycholinesterase-catalyzed hydrolysis of the isomeric dl-3-trimethylammonium-2-acetoxy-trans-decalin halides and the isomeric dl-1-methyl-3-acetoxy-trans-decahydroquinoline methiodides

1972 • 8 citations

Acetylcholinesterase inhibition by the ketone transition state analogs phenoxyacetone and 1-halo-3-phenoxy-2-propanones

1982 • 8 citations