CD 127⁻ and FoxP3⁺ Expression on CD25⁺CD4⁺ T Regulatory Cells upon Specific Diabetogeneic Stimulation in High‐risk Relatives of Type 1 Diabetes Mellitus Patients

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

2006 • 2,516 citations

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

2006 • 1,496 citations

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

2003 • 1,252 citations

Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes

2005 • 825 citations

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

2004 • 805 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 645 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 548 citations

Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells

2005 • 525 citations

The role of T-cells in the pathogenesis of Type 1 diabetes: From cause to cure

2003 • 410 citations

Functional Defects and the Influence of Age on the Frequency of CD4+CD25+ T-Cells in Type 1 Diabetes

2005 • 384 citations

Imbalance of regulatory T cells in human autoimmune diseases

2005 • 359 citations

How do CD4+CD25+ regulatory T cells control autoimmunity?

2005 • 249 citations

No Alterations in the Frequency of FOXP3+ Regulatory T-Cells in Type 1 Diabetes

2007 • 242 citations

Absolute Risk of Childhood-Onset Type 1 Diabetes Defined by Human Leukocyte Antigen Class II Genotype: A Population-Based Study in the United Kingdom

2004 • 235 citations

The phenotypic characterization of naturally occurring regulatory CD4+CD25+ T cells.

2006 • 141 citations

FOXP3⁺ regulatory T cells: Current controversies and future perspectives

2006 • 130 citations

Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells

2003 • 82 citations

The dichotomous role of IL-2: tolerance versus immunity

2006 • 81 citations

Characterization of Preparations of GAD65, Proinsulin, and the Islet Tyrosine Phosphatase IA-2 for Use in Detection of Autoreactive T-Cells in Type 1 Diabetes

2001 • 79 citations

Th1-like dominance in high-risk first-degree relatives of Type I diabetic patients

2000 • 78 citations

A Mini Meta‐Analysis of Studies on CD4⁺CD25⁺ T cells in Human Type 1 Diabetes

2006 • 77 citations

Foxp3 Represses Retroviral Transcription by Targeting Both NF-κB and CREB Pathways

2006 • 77 citations

NFAT transcription factors in control of peripheral T cell tolerance

2006 • 65 citations

Phenotypic and genetic analyses of T‐cell‐mediated immunoregulation in patients with Type 1 diabetes

2006 • 53 citations

Autoimmune Diseases as the Loss of Active “Self‐Control”

2003 • 45 citations

Type 1 diabetes risk assessment: improvement by follow-up measurements in young islet autoantibody-positive relatives

2006 • 45 citations

Detection of Autoreactive T Cells in Type 1 Diabetes Using Coded Autoantigens and an Immunoglobulin‐Free Cytokine ELISPOT Assay: Report from the Fourth Immunology of Diabetes Society T Cell Workshop

2004 • 40 citations

Autoreactive T cells in human type 1 diabetes

2004 • 29 citations

Activation of CD4⁺CD25⁺ regulatory T cell suppressor function by analogs of the selecting peptide

2006 • 25 citations

Immune Regulatory T Cells in Siblings of Children Suffering from Type 1 Diabetes Mellitus

2006 • 19 citations

[Prediction of insulin-dependent diabetes mellitus in children of first-degree relatives of diabetic patients].

2001 • 8 citations