Potential mechanisms of human natural killer cell expansion in vivo during low-dose IL-2 therapy

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Biology of Natural Killer Cells

1989 • 2,970 citations

Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor.

1994 • 1,079 citations

Biology and clinical relevance of human natural killer cells

1990 • 930 citations

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Role of interleukin-15 in the development of human CD56+ natural killer cells from CD34+ hematopoietic progenitor cells

1996 • 495 citations

Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors.

1990 • 436 citations

Selective modulation of human natural killer cells in vivo after prolonged infusion of low dose recombinant interleukin 2.

1993 • 259 citations

Review: Granulocyte Colony-Stimulating Factor--Role and Relationships in Infectious Diseases

1995 • 235 citations

Flt3 Ligand Promotes the Generation of a Distinct CD34+Human Natural Killer Cell Progenitor That Responds to Interleukin-15

1998 • 222 citations

Constitutive expression of high affinity interleukin 2 receptors on human CD16-natural killer cells in vivo.

1990 • 219 citations

Differentiation of natural killer (NK) cells from human primitive marrow progenitors in a stroma-based long-term culture system: identification of a CD34+7+ NK progenitor

1994 • 198 citations

The generation of human natural killer cells from CD34+/DR- primitive progenitors in long-term bone marrow culture

1992 • 167 citations

Differentiation of natural killer (NK) cells from human primitive marrow progenitors in a stroma-based long-term culture system: identification of a CD34+7+ NK progenitor

1994 • 164 citations

Soluble stem cell factor in human serum

1993 • 151 citations

BrdU—Hoechst flow cytometry: A unique tool for quantitative cell cycle analysis

1988 • 148 citations

Expression of a functional c-kit receptor on a subset of natural killer cells.

1993 • 143 citations

Proliferation is a prerequisite for bacterial superantigen-induced T cell apoptosis in vivo.

1995 • 123 citations

Accumulation of CD16⁻CD56⁺ natural killer cells with high affinity interleukin 2 receptors in human early pregnancy decidua

1991 • 112 citations

Lymphokine requirement for the generation of natural killer cells from CD34+ hematopoietic progenitor cells

1995 • 100 citations

Prolonged administration of low-dose interleukin-2 in human immunodeficiency virus-associated malignancy results in selective expansion of innate immune effectors without significant clinical toxicity

1995 • 93 citations

Genesis of human oncolytic natural killer cells from primitive CD34+CD33- bone marrow progenitors.

1993 • 87 citations

Daily subcutaneous injection of low-dose interleukin 2 expands natural killer cells in vivo without significant toxicity.

1996 • 70 citations

Generation of human natural killer cells from immature progenitors does not require marrow stromal cells

1994 • 62 citations

Lymphomagenesis in the SCID-hu mouse involves abundant production of human interleukin-10

1995 • 61 citations

Ultra low dose interleukin-2 therapy promotes a type 1 cytokine profile in vivo in patients with AIDS and AIDS-associated malignancies.

1998 • 59 citations

Stem Cell Factor Enhances Interleukin-2–Mediated Expansion of Murine Natural Killer Cells In Vivo

1997 • 40 citations

Signal Transduction, Mitotic Catastrophes, and Death in T‐Cell Development

1994 • 36 citations

High-dose cytarabine, idarubicin, and granulocyte colony-stimulating factor remission induction therapy for previously untreated de novo and secondary adult acute myeloid leukemia.

1993 • 17 citations