Roles of oxidative stress in activation of Kupffer and Ito cells in liver fibrogenesis

Oxidants and human disease: some new concepts ¹

1987 • 1,171 citations

Experimental liver cirrhosis induced by alcohol and iron.

1995 • 520 citations

Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors.

1989 • 401 citations

Regulation of interleukin 8 gene expression by oxidant stress.

1993 • 395 citations

Stimulation of Lipid Peroxidation or 4-Hydroxynonenal Treatment Increases Procollagen α1 (I) Gene Expression in Human Liver Fat-Storing Cells

1993 • 337 citations

Stimulation of Collagen Gene Expression by Ascorbic Acid in Cultured Human Fibroblasts

1989 • 312 citations

Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload.

1990 • 244 citations

Inhibition of NF-κB Activation by Vitamin E Derivatives

1993 • 243 citations

Vitamin E dietary supplementation protects against carbon tetrachloride—induced chronic liver damage and cirrhosis

1992 • 238 citations

Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: Association of lipid peroxidation with liver fibrogenesis

1992 • 235 citations

Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis–dependent mechanism

1991 • 185 citations

S –Adenosylmethionine Treatment Prevents Carbon Tetrachloride—Induced S –Adenosylmethionine Synthetase Inactivation and Attenuates Liver Injury

1992 • 160 citations

Acetaldehyde increases collagen gene transcription in cultured human fibroblasts.

1987 • 143 citations

d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. Modulation of constitutive collagen gene expression by lipid peroxidation.

1991 • 124 citations

Effects of 4-hydroxynonenal on adenylate cyclase and 5′-nucleotidase activities in rat liver plasma membranes

1985 • 114 citations

Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis-dependent mechanism, ,

1991 • 77 citations

Centrilobular distribution of acetaldehyde and collagen in the ethanol-fed micropig

1993 • 67 citations

Sensitization of hepatic lipocytes by high-fat diet to stimulatory effects of kupffer cell-derived factors: Implication in alcoholic liver fibrogenesis

1990 • 62 citations

4-Hydroxynonenal induces a DNA-binding protein similar to the heat-shock factor

1989 • 57 citations

Stimulation of phospholipase C activity by 4-hydroxynonenal; influence of GTP and calcium concentration.

1988 • 28 citations

Acetaldehyde-collagen adducts in N-nitrosodimethylamine-induced liver cirrhosis in rats

1993 • 23 citations

Coordinate Inhibition by Some Antioxidants of TNFα, IL‐1β, and IL‐6 Production by Human Peripheral Blood Mononuclear Cells

1993 • 15 citations

Serum procollagen type III peptide in chronic hepatitis B treated with recombinant interferon alfa-2b

1990 • 7 citations

Antioxidants modulate monocyte/Kupffer cell tumor necrosis factor prduction

1993 • 2 citations

Enhanced NF-$kappa;B binding is associated with free radical-induced acute hepatic injury . Departments of Medicine, Jefferson Medical College, Philadelphia, PA, Brown University, Providence, RI, and Johns Hopkins University, Baltimore, MD

1993 • 1 citations