Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366

Antibodies, a laboratory manual

1989 • 12,929 citations

Cell cycle checkpoint signaling through the ATM and ATR kinases

2001 • 1,962 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

1998 • 1,588 citations

Chk1 is an essential kinase that is regulated by Atr and required for the G₂/M DNA damage checkpoint

2000 • 1,583 citations

The PI3K–PDK1 connection: more than just a road to PKB

2000 • 1,563 citations

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

1997 • 1,285 citations

Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase

1998 • 1,176 citations

ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

2001 • 1,036 citations

Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

1999 • 801 citations

THE GENETIC DEFECT IN ATAXIA-TELANGIECTASIA

1997 • 637 citations

Genomic Expression Responses to DNA-damaging Agents and the Regulatory Role of the Yeast ATR Homolog Mec1p

2001 • 556 citations

Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence

1999 • 542 citations

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

2000 • 500 citations

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

2001 • 494 citations

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

2000 • 487 citations

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

2002 • 473 citations

Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53

1992 • 473 citations

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

2002 • 425 citations

Germline and Somatic Mutations of the STK11/LKB1 Peutz-Jeghers Gene in Pancreatic and Biliary Cancers

1999 • 417 citations

Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation.

2000 • 395 citations

The Peutz-Jegher Gene Product LKB1 Is a Mediator of p53-Dependent Cell Death

2001 • 316 citations

Activation of mammalian Chk1 during DNA replication arrest

2001 • 307 citations

ATM: Genome stability, neuronal development, and cancer cross paths

2001 • 304 citations

Growth suppression by Lkb1 is mediated by a G ₁ cell cycle arrest

1999 • 289 citations

The DNA-dependent Protein Kinase Is Inactivated by Autophosphorylation of the Catalytic Subunit

1996 • 287 citations

Phosphorylation of the Protein Kinase Mutated in Peutz-Jeghers Cancer Syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent Protein Kinase, but Not Its Farnesylation at Cys433, Is Essential for LKB1 to Suppress Cell Growth

2001 • 271 citations

Recombinant ATM protein complements the cellular A-T phenotype

1997 • 242 citations

DNA damage and the DNA-activated protein kinase

1993 • 237 citations

The molecular basis and clinical aspects of Peutz-Jeghers syndrome

1999 • 219 citations

LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo

2000 • 210 citations

Growth arrest by the LKB1 tumor suppressor: induction of p21WAF1/CIP1

2002 • 197 citations

Utilization of Oriented Peptide Libraries to Identify Substrate Motifs Selected by ATM

2000 • 190 citations

The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

1999 • 186 citations

Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome.

1998 • 181 citations

Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM

1999 • 173 citations

Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer

1999 • 159 citations

Peutz-Jeghers syndrome: 78-year follow-up of the original family

1999 • 152 citations

Role of Lkb1 , the causative gene of Peutz–Jegher's syndrome, in embryogenesis and polyposis

2002 • 150 citations

Induction of cyclooxygenase-2 in a mouse model of Peutz–Jeghers polyposis

2002 • 126 citations

Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice.

2002 • 125 citations

LKB1 Associates with Brg1 and Is Necessary for Brg1-induced Growth Arrest

2001 • 124 citations

Interferon regulatory factor-3 is an in vivo target of DNA-PK

2002 • 120 citations

LKB1 — A master tumour suppressor of the small intestine and beyond

2002 • 119 citations

STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer.

1998 • 92 citations

LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1

2001 • 91 citations

Peutz-Jeghers families unlinked toSTK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma

2001 • 90 citations

Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer.

1998 • 89 citations

Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz‒Jeghers cancer syndrome

2002 • 88 citations

Purification and characterization of the double-stranded DNA-activated protein kinase, DNA-PK, from human placenta

1996 • 81 citations

Ataxia-telangiectasia and the ATM gene: Linking neurodegeneration, immunodeficiency, and cancer to cell cycle checkpoints

1996 • 80 citations

The Mouse Peutz-Jeghers Syndrome Gene Lkbl Encodes a Nuclear Protein Kinase

1999 • 80 citations

Identification of protein phosphorylation sites by a combination of mass spectrometry and solid phase Edman sequencing.

2002 • 77 citations

Germline mutations of the LKB1 (STK11) gene in Peutz-Jeghers patients.

1999 • 71 citations

Analysis of the Specificity of the AMP‐Activated Protein Kinase by Site‐Directed Mutagenesis of Bacterially Expressed 3‐hydroxy 3‐methylglutaryl‐CoA Reductase, Using a Single Primer Variant of the Unique‐site‐elimination Method

1996 • 48 citations

Mutations of the STK11 gene in sporadic gastric carcinoma.

1998 • 48 citations

Germline mutations of the STK11 gene in Korean Peutz-Jeghers syndrome patients.

2000 • 46 citations

Detection of DNA-Dependent Protein Kinase in Extracts from Human and Rodent Cells

2003 • 12 citations