LKB1 Associates with Brg1 and Is Necessary for Brg1-induced Growth Arrest

de la Chapelle, A.

1997 • 3,184 citations

A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

1998 • 1,588 citations

Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer

1998 • 1,472 citations

Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase

1998 • 1,176 citations

Increased Risk of Cancer in the Peutz–Jeghers Syndrome

1987 • 865 citations

Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.

1996 • 830 citations

A Brg1 Null Mutation in the Mouse Reveals Functional Differences among Mammalian SWI/SNF Complexes

2000 • 811 citations

Diversity and specialization of mammalian SWI/SNF complexes.

1996 • 703 citations

BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription

1993 • 668 citations

Exit from G1 and S Phase of the Cell Cycle Is Regulated by Repressor Complexes Containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF

2000 • 650 citations

Generalized Intestinal Polyposis and Melanin Spots of the Oral Mucosa, Lips and Digits

1949 • 644 citations

The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

1994 • 625 citations

Reconstitution of a Core Chromatin Remodeling Complex from SWI/SNF Subunits

1999 • 608 citations

A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor.

1993 • 598 citations

BRCA1 Is Associated with a Human SWI/SNF-Related Complex

2000 • 548 citations

Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex

1998 • 507 citations

Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis

1997 • 487 citations

Two human homologues ofSaccharomyces cerevisiae SWI2/SNF2andDrosophila brahmaare transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor

1994 • 338 citations

Growth suppression by Lkb1 is mediated by a G ₁ cell cycle arrest

1999 • 289 citations

Phosphorylation of the Protein Kinase Mutated in Peutz-Jeghers Cancer Syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent Protein Kinase, but Not Its Farnesylation at Cys433, Is Essential for LKB1 to Suppress Cell Growth

2001 • 271 citations

Mitotic inactivation of a human SWI/SNF chromatin remodeling complex

1998 • 257 citations

Functional Interactions between the hBRM/hBRG1 Transcriptional Activators and the pRB Family of Proteins

1996 • 252 citations

BRG-1 is required for RB-mediated cell cycle arrest

2000 • 245 citations

The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry

2000 • 231 citations

The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis.

1996 • 228 citations

Components of the Human SWI/SNF Complex Are Enriched in Active Chromatin and Are Associated with the Nuclear Matrix

1997 • 226 citations

BRG-1 Is Recruited to Estrogen-Responsive Promoters and Cooperates with Factors Involved in Histone Acetylation

2000 • 221 citations

LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo

2000 • 210 citations

Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome

2000 • 182 citations

Cyclin E Associates with BAF155 and BRG1, Components of the Mammalian SWI-SNF Complex, and Alters the Ability of BRG1 To Induce Growth Arrest

1999 • 163 citations

Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2

1997 • 160 citations

Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer

1999 • 159 citations

Glucocorticoid Receptor-Glucocorticoid Response Element Binding Stimulates Nucleosome Disruption by the SWI/SNF Complex

1997 • 159 citations

A human protein with homology toSaccharomyces cerevisiaeSNF5 interacts with the potential helicase hbrm

1995 • 141 citations

Human SWI-SNF Component BRG1 Represses Transcription of the c-fos Gene

1999 • 131 citations

LKB1 Somatic Mutations in Sporadic Tumors

1999 • 128 citations

brg1: A Putative Murine Homologue of the Drosophila brahma Gene, a Homeotic Gene Regulator

1994 • 104 citations

Somatic Mutations in the Peutz-Jegners (LKB1/STKII) Gene in Sporadic Malignant Melanomas

1999 • 100 citations

Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome

2001 • 95 citations

Cloning and Characterization of a Novel Serine/Threonine Protein Kinase Expressed in Early Embryos

1996 • 87 citations

The Mouse Peutz-Jeghers Syndrome Gene Lkbl Encodes a Nuclear Protein Kinase

1999 • 80 citations

Restoration of retinoblastoma mediated signaling to Cdk2 results in cell cycle arrest

2000 • 77 citations

Loss of Cytoplasmic Retention Ability of Mutant LKB1 Found in Peutz-Jeghers Syndrome Patients

1999 • 70 citations

Small pool expression screening: Identification of genes involved in cell cycle control, apoptosis, and early development

1997 • 67 citations

Epstein–Barr Virus EBNA-2 Gene Expression Enhances Lymphotoxin Production by B Lymphocytes

1997 • 27 citations

Identification of a Novel mRNA Species of theLKB1/STK11Peutz-Jeghers Serine/Threonine Kinase

1999 • 4 citations