A pharmacokinetically based propofol dosing strategy for sedation of the critically ill, mechanically ventilated pediatric patient

Context-sensitive Half-time in Multicompartment

1992 • 775 citations

Assessing Distress in Pediatric Intensive Care Environments: The COMFORT Scale

1992 • 747 citations

The Pharmacokinetics of the New Short-acting Opioid Remifentanil (GI87084B) in Healthy Adult Male Volunteers

1993 • 622 citations

Metabolic acidosis and fatal myocardial failure after propofol infusion in children: five case reports.

1992 • 572 citations

Disposition of Propofol Administered as Constant Rate Intravenous Infusions in Humans

1987 • 461 citations

The Pharmacokinetics of Propofol in Children Using Three Different Data Analysis Approaches

1994 • 320 citations

Improved method for the determination of propofol in blood by high-performance liquid chromatography with fluorescence detection

1987 • 311 citations

Lean Body Mass as a Predictor of Drug Dosage

1994 • 290 citations

Use of Sedating Drugs and Neuromuscular Blocking Agents in Patients Requiring Mechanical Ventilation for Respiratory Failure. A National Survey

1992 • 273 citations

Propofol vs Midazolam in Short-, Medium-, and Long-term Sedation of Critically III Patients

1993 • 252 citations

Use of Sedating Drugs and Neuromuscular Blocking Agents in Patients Requiring Mechanical Ventilation for Respiratory Failure

1991 • 238 citations

Mechanical Ventilation

1994 • 236 citations

Neuromuscular Blockade in the Intensive Care Unit: More than We Bargained for

1993 • 183 citations

Comparison of propofol and midazolam for sedation in intensive care unit patients

1995 • 178 citations

The Nonhypnotic Therapeutic Applications of Propofol

1994 • 160 citations

Optimal sedation of mechanically ventilated pediatric critical care patients

1994 • 151 citations

Advances in propofol pharmacokinetics and pharmacodynamics

1993 • 149 citations

Propofol and Spontaneous Movements

1991 • 148 citations

Prolonged paralysis in intensive care unit patients after the use of neuromuscular blocking agents

1994 • 148 citations

Reversible neurologic abnormalities associated with prolonged intravenous midazolam and fentanyl administration

1991 • 145 citations

Continous intravenous infusion and multicompartment accumulation

1968 • 141 citations

COMPUTER CONTROLLED INFUSION OF PROPOFOL

1989 • 130 citations

PROLONGED SEDATION WITH PROPOFOL IN ICU PATIENTS: RECOVERY AND BLOOD CONCENTRATION CHANGES DURING PERIODIC INTERRUPTIONS IN INFUSION

1988 • 126 citations

Pharmacokinetics of Long-Term Propofol Infusion Used for Sedation in ICU Patients

1990 • 121 citations

Fatal metabolic acidosis in a pediatric patient receiving an infusion of propofol in the intensive care unit

1995 • 119 citations

A prospective evaluation of pharmacokinetic model controlled infusion of propofol in paediatric patients

1994 • 107 citations

Pharmacokinetic Model-driven Infusion of Fentanyl

1990 • 105 citations

PHARAMACOKINETICS OF PROPOFOL IN YOUNG CHILDREN AFTER A SINGLE DOSE

1989 • 99 citations

Propofol for long‐term sedation in the intensive care unit* A comparison with papaveretum and midazolam

1990 • 93 citations

PHARMACOKINETICS OF PROPOFOL IN CHILDREN

1990 • 90 citations

The Dose of Propofol Required to Prevent Children from Moving during Magnetic Resonance Imaging

1993 • 83 citations

Propofol in patients with cardiac disease

1993 • 82 citations

Pediatric intensive care sedation: survey of fellowship training programs.

1993 • 74 citations

Propofol Requirements for Induction of Anesthesia in Children of Different Age Groups

1992 • 56 citations

Concentration- or effect-controlled clinical trials with sparse data

1994 • 53 citations

Plasma Drug Efflux-A New Approach to Optimization of Drug Infusion for Constant Blood Concentration of Thiopental and Methohexital

1987 • 50 citations

Algorithm for optimal linear model-based control with application to pharmacokinetic model-driven drug delivery

1990 • 44 citations

Propofol: A Review of the Pharmacology and Applications of an Intravenous Anesthetic Agent

1992 • 39 citations

Propofol infusion for sedation of children

1990 • 22 citations

Distribution of indomethacin in human milk and estimation of its milk to plasma ratio in vitro

1993 • 17 citations