Flow cytometric measurement of p53 protein expression and DNA content in paraffin‐embedded tissue from bronchial carcinomas

Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.

1984 • 4,180 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry.

1983 • 2,066 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

p53 mutations in colorectal cancer.

1990 • 1,030 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

1984 • 761 citations

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1984 • 754 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

P53 expression in breast cancer

1988 • 612 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

Growth regulation of a cellular tumour antigen, p53, in nontransformed cells

1984 • 524 citations

Isolation of human‐p53‐specific monoclonal antibodies and their use in the studies of human p53 expression

1986 • 508 citations

Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung.

1987 • 487 citations

Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer

1982 • 448 citations

Allelic losses of chromosomes 9, 11, and 17 in human bladder cancer.

1990 • 327 citations

Meth A fibrosarcoma cells express two transforming mutant p53 species.

1988 • 247 citations

Different Tumor-Derived p53 Mutants Exhibit Distinct Biological Activities

1990 • 245 citations

Overproduction of p53 antigen makes established cells highly tumorigenic

1985 • 217 citations

Expression of the nuclear oncogene p53 in colon tumours

1989 • 173 citations

Presence of circulating antibodies against cellular protein p53 in a notable proportion of children with B-cell lymphoma

1987 • 134 citations

Different forms of p53 detected by monoclonal antibodies in non-dividing and dividing lymphocytes

1984 • 126 citations

The cellular protein p53 in human tumours.

1984 • 104 citations

Simultaneous monitoring of P53 protein and dna content of colorectal adenocarcinomas by flow cytometry

1990 • 81 citations

Modulation of the nuclear antigen p105 as a function of cell‐cycle progression

1987 • 67 citations

Colorectal cancer genes

1990 • 39 citations

Modulation of Mr 53,000 protein with induction of differentiation of human neuroblastoma cells.

1988 • 33 citations

Limitations in the measurement of c‐myc oncoprotein and other nuclear antigens by flow cytometry

1989 • 21 citations

Small cell lung cancer

1989 • 19 citations