Selective Pharmacological Agents Implicate Mitochondrial but Not Sarcolemmal K _ATP Channels in Ischemic Cardioprotection

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

1986 • 7,740 citations

ATP-regulated K+ channels in cardiac muscle

1983 • 2,350 citations

Decoding of cytosolic calcium oscillations in the mitochondria

1995 • 1,090 citations

Cardioprotective Effect of Diazoxide and Its Interaction With Mitochondrial ATP-Sensitive K ⁺ Channels

1997 • 1,032 citations

A Family of Sulfonylurea Receptors Determines the Pharmacological Properties of ATP-Sensitive K+ Channels

1996 • 968 citations

Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs.

1992 • 961 citations

Mitochondrial ATP-Dependent Potassium Channels

1998 • 825 citations

ATP-sensitive K+ channel in the mitochondrial inner membrane

1991 • 746 citations

The Mitochondrial K Channel as a Receptor for Potassium Channel Openers

1996 • 447 citations

Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea‐sensitive but ATP‐insensitive K+ channel.

1997 • 390 citations

Modulation of Mitochondrial ATP-Dependent K ⁺ Channels by Protein Kinase C

1998 • 368 citations

Blockade of ischaemic preconditioning in dogs by the novel ATP dependent potassium channel antagonist sodium 5-hydroxydecanoate

1992 • 282 citations

Effects of the KATP channel opener bimakalim on coronary blood flow, monophasic action potential duration, and infarct size in dogs.

1994 • 259 citations

Synergistic Modulation of ATP-Sensitive K ⁺ Currents by Protein Kinase C and Adenosine

1996 • 175 citations

Ischemic preconditioning depends on interaction between mitochondrial K_ATPchannels and actin cytoskeleton

1999 • 168 citations

Bimakalim, an ATP-Sensitive Potassium Channel Opener, Mimics the Effects of Ischemic Preconditioning to Reduce Infarct Size, Adenosine Release, and Neutrophil Function in Dogs

1995 • 143 citations

Pharmacological and Histochemical Distinctions Between Molecularly Defined Sarcolemmal K_ATPChannels and Native Cardiac Mitochondrial K_ATPChannels

1999 • 132 citations

The Ischemia-selective KATPChannel Antagonist, 5-Hydroxydecanoate, Blocks Ischemic Preconditioning in the Rat Heart

1997 • 124 citations

Direct effects of diazoxide on mitochondria in pancreatic B‐cells and on isolated liver mitochondria

1998 • 121 citations

Ischaemic preconditioning: can the protection be bottled?

1993 • 107 citations

HMR 1883, a novel cardioselective inhibitor of the ATP-sensitive potassium channel. Part I: effects on cardiomyocytes, coronary flow and pancreatic beta-cells.

1998 • 93 citations

Potassium channels and preconditioning of isolated rabbit cardiomyocytes: Effects of glyburide and pinacidil

1995 • 93 citations

Direct preconditioning of cardiac ventricular myocytes via adenosine A1 receptor and KATP channel

1996 • 87 citations

Kinetics of mitochondrial flavoprotein and pyridine nucleotide in perfused heart

1972 • 80 citations

An in vitro model of myocardial ischemia utilizing isolated adult rat myocytes

1990 • 79 citations

Limitation of myocardial infarct size in the rabbit by ischaemic preconditioning is abolished by sodium 5-hydroxydecanoate

1996 • 75 citations

Is the chemical gate of connexins voltage sensitive? Behavior of Cx32 wild-type and mutant channels

1999 • 73 citations

Preconditioning is not abolished by the delayed rectifier K+ blocker dofetilide

1996 • 69 citations

Coordinate Interaction Between ATP-Sensitive K ⁺ Channel and Na ⁺ ,K ⁺ -ATPase Modulates Ischemic Preconditioning

1998 • 49 citations

Cardioprotective Effects of the Cyanoguanidine Potassium Channel Opener P-1075

1993 • 32 citations

Blockade of ATP-sensitive potassium channels by 5-hydroxydecanoate suppresses monophasic action potential shortening during regional myocardial ischemia

1994 • 31 citations

5-Hydroxydecanoate selectively reduces the initial increase in extracellular K+ in ischemic guinea-pig heart

1998 • 23 citations

A specific activator of the ATP-inhibited K+ channels in guinea pig ventricular cells.

1993 • 14 citations