HMR 1883, a novel cardioselective inhibitor of the ATP-sensitive potassium channel. Part I: effects on cardiomyocytes, coronary flow and pancreatic beta-cells.

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

ATP-regulated K+ channels in cardiac muscle

1983 • 2,350 citations

Reconstitution of I _KATP : An Inward Rectifier Subunit Plus the Sulfonylurea Receptor

1995 • 1,703 citations

Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction

1989 • 995 citations

A Family of Sulfonylurea Receptors Determines the Pharmacological Properties of ATP-Sensitive K+ Channels

1996 • 968 citations

Adenosine 5'-Triphosphate-Sensitive Potassium Channels

1988 • 888 citations

Hypoxic Dilation of Coronary Arteries Is Mediated by ATP-Sensitive Potassium Channels

1990 • 600 citations

A Novel Sulfonylurea Receptor Forms with BIR (Kir6.2) a Smooth Muscle Type ATP-sensitive K+ Channel

1996 • 539 citations

Effect of acute coronary artery occlusion on local myocardial extracellular K+ activity in swine.

1980 • 478 citations

Calcium and delayed potassium currents in mouse pancreatic beta‐cells under voltage‐clamp conditions.

1986 • 370 citations

Membrane current through adenosine‐triphosphate‐regulated potassium channels in guinea‐pig ventricular cells.

1985 • 260 citations

Potassium accumulation in the globally ischemic mammalian heart. A role for the ATP-sensitive potassium channel.

1990 • 228 citations

Reduction of ischemic K+ loss and arrhythmias in rat hearts. Effect of glibenclamide, a sulfonylurea.

1990 • 222 citations

Ionic currents during hypoxia in voltage-clamped cat ventricular muscle.

1980 • 168 citations

Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts

1989 • 156 citations

Profibrillatory Actions of Pinacidil in a Conscious Canine Model of Sudden Coronary Death

1990 • 151 citations

Mechanism of potassium efflux and action potential shortening during ischaemia in isolated mammalian cardiac muscle.

1990 • 145 citations

Interaction of diazoxide, tolbutamide and ATP4− on nucleotide-dependent K+ channels in an insulin-secreting cell line

1987 • 132 citations

Inhibition of ATP-sensitive K+ channels in cardiac muscle by the sulphonylurea drug glibenclamide.

1992 • 102 citations

Effectiveness of glibenclamide on myocardial ischemic ventricular arrhythmias in non-insulin-dependent diabetes mellitus

1991 • 97 citations

The Effects of the ATP-Dependent Potassium Channel Antagonist, Glyburide, on Coronary Blood Flow and Susceptibility to Ventricular Fibrillation in Unanesthetized Dogs

1993 • 96 citations

HMR 1883, a novel cardioselective inhibitor of the ATP-sensitive potassium channel. Part II: effects on susceptibility to ventricular fibrillation induced by myocardial ischemia in conscious dogs.

1998 • 95 citations

Effects of tolbutamide, glibenclamide and diazoxide upon action potentials recorded from rat ventricular muscle

1989 • 94 citations

Activation of cardiac ATP-sensitive K+ current during hypoxia: correlation with tissue ATP levels

1991 • 94 citations

Effects of ATP‐sensitive K⁺ channel blockers on the action potential shortening in hypoxic and ischaemic myocardium

1991 • 91 citations

Sulphonylurea drugs no longer inhibit ATP-sensitive K+ channels during metabolic stress in cardiac muscle.

1993 • 87 citations

Arrhythmias and Mortality After Myocardial Infarction in Diabetic Patients: Relationship to diabetes treatment

1998 • 62 citations

Adenosine triphosphate-sensitive potassium channel blocking agent ameliorates, but the opening agent aggravates, ischemia/reperfusion-induced injury

1994 • 61 citations

Effects of pH upon the inhibition by sulphonylurea drugs of ATP-sensitive K+ channels in cardiac muscle.

1992 • 57 citations

Adenosine triphosphate-dependent K currents activated by metabolic inhibition in rat ventricular myocytes differ from those elicited by the channel opener rilmakalim

1995 • 56 citations

Actions of Pinacidil at a Reduced Potassium Concentration

1993 • 49 citations

Effects of drugs on ventricular fibrillation and ischaemic K+ loss in a model of ischaemia in perfused guinea-pig hearts in vitro

1992 • 34 citations

Inhibitory effects of berberine on ATP-sensitive K+ channels in cardiac myocytes

1996 • 30 citations

HOE-234, a second generation K+ channel opener, antagonizes the ATP-dependent gating of cardiac ATP-sensitive K+ channels.

1994 • 29 citations

Effects of ATP-dependent K+ channel modulators on an ischemia-reperfusion rabbit isolated heart model with programmed electrical stimulation

1994 • 20 citations

The involvement of ATP‐sensitive potassium channels in β₂‐adrenoceptor agonist‐induced vasodilatation on rat diaphragmatic microcirculation

1997 • 20 citations

Influence of oral antidiabetic treatment on electrocardiac alterations induced by myocardial infarction

1996 • 16 citations

Effects of cromakalim, pinacidil and glibenclamide on cholinergic transmission in rat isolated atria

1995 • 13 citations

α1-Adrenoceptor Stimulation Partially Inhibits ATP-Sensitive K+ Current in Guinea Pig Ventricular Cells: Attenuation of the Action Potential Shortening Induced by Hypoxia and K+ Channel Openers

1996 • 13 citations

Cardiovascular effects of the novel potassium channel opener (3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxo- 1-pyrrolidinyl)-6-phenylsulfonylchromane hemihydrate.

1992 • 9 citations

Arrhythmia and electrical heterogeneity during prolonged hypoxia in guinea pig papillary muscles

1997 • 4 citations