Effect of the A118G polymorphism on binding affinity, potency and agonist‐mediated endocytosis, desensitization, and resensitization of the human mu‐opioid receptor

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1998 • 1,055 citations

Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization

1996 • 938 citations

Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.

1988 • 897 citations

Regulatory mechanisms that modulate signalling by G-protein-coupled receptors

1997 • 502 citations

Role for G protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness

1998 • 501 citations

Molecular mechanisms of membrane receptor desensitization

1993 • 442 citations

Multiple opioid receptors: ligand selectivity profiles and binding site signatures.

1989 • 441 citations

Morphine-activated opioid receptors elude desensitization by β-arrestin

1998 • 374 citations

Sequence variability and candidate gene analysis in complex disease: association of micro opioid receptor gene variation with substance dependence

2000 • 291 citations

μ opioid receptor gene variants: lack of association with alcohol dependence

1997 • 278 citations

The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C

1995 • 245 citations

A Single Nucleotide Polymorphic Mutation in the Human μ-Opioid Receptor Severely Impairs Receptor Signaling

2001 • 243 citations

-mu opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity.

1994 • 236 citations

The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine

2002 • 208 citations

Carboxyl-terminal Splicing of the Rat μ Opioid Receptor Modulates Agonist-mediated Internalization and Receptor Resensitization

1998 • 190 citations

C-terminal Splice Variants of the Mouse µ-Opioid Receptor Differ in Morphine-induced Internalization and Receptor Resensitization

2001 • 162 citations

Opioid receptor and peptide gene polymorphisms: potential implications for addictions

2000 • 153 citations

Does the A118G Polymorphism at the μ-opioid Receptor Gene Protect against Morphine-6-Glucuronide Toxicity?

2002 • 144 citations

Cloning and Expression of a DNA Sequence Conferring Cephamycin C Production

1988 • 123 citations

The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors.

1996 • 115 citations

ADP-ribosylation Factor-dependent Phospholipase D2 Activation Is Required for Agonist-induced μ-Opioid Receptor Endocytosis

2003 • 98 citations

Involvement of Mitogen‐Activated Protein Kinase in Agonist‐Induced Phosphorylation of the μ‐Opioid Receptor in HEK 293 Cells

2000 • 97 citations

μ‐Opioid Receptor Stimulation of Inositol (1,4,5)Trisphosphate Formation via a Pertussis Toxin‐Sensitive G Protein

1994 • 95 citations

Opioid withdrawal activates MAP kinase in locus coeruleus neurons in morphine‐dependent rats in vivo

1998 • 92 citations

μ-opioids activate phospholipase C in SH-SY5Y human neuroblastoma cells via calcium-channel opening

1995 • 81 citations

Allelic Variation S268P of the Human μ-Opioid Receptor Affects Both Desensitization and G Protein Coupling

2000 • 73 citations

Involvement of phospholipid signal transduction pathways in morphine tolerance in mice

1999 • 68 citations

Characterization of dopamine receptor binding sites in the subthalamic nucleus

1994 • 62 citations

Expressed mu opiate receptor couples to adenylate cyclase and phosphatidyl inositol turnover

1994 • 61 citations

Adrenergic receptors: recent insights into their mechanism of activation and desensitization.

1993 • 51 citations

Agonist‐induced signaling and trafficking of the μ‐opioid receptor: role of serine and threonine residues in the third cytoplasmic loop and C‐terminal domain

1997 • 51 citations

The role of diacylglycerol and activation of protein kinase C in α_1A‐adrenoceptor‐mediated contraction to noradrenaline of rat isolated epididymal vas deferens

1996 • 33 citations

Association analysis of polymorphisms in the mu opioid gene and heroin abuse in Chinese subjects

2000 • 32 citations

Studies of binding and internalization of human recombinant monocyte chemotactic and activating factor (MCAF) by monocytic cells

1993 • 27 citations

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