Opiate receptors modulate estrogen-induced cholecystokinin and tachykinin but not enkephalin messenger RNA levels in the limbic system and hypothalamus

Anatomy of CNS opioid receptors

1988 • 1,178 citations

Opiate analgesics inhibit substance P release from rat trigeminal nucleus

1977 • 968 citations

Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A.

1987 • 651 citations

Evidence for the Neuropeptide Cholecystokinin as an Antagonist of Opiate Analgesia

1983 • 582 citations

Opioid receptor-coupled second messenger systems

1991 • 466 citations

Distribution of cells containing mRNAs encoding substance P and neurokinin B in the rat central nervous system

1988 • 316 citations

Localization of oestrogen receptors in preoptic neurons containing neurotensin but not tyrosine hydroxylase, cholecystokinin or luteinizing hormone-releasing hormone in the male and female rat

1992 • 273 citations

Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide gamma

1990 • 227 citations

Autoradiographic distribution of substance P receptors in rat central nervous system

1983 • 225 citations

Substance P receptors: Localization by light microscopic autoradiography in rat brain using [3H]SP as the radioligand

1984 • 220 citations

Opiate inhibition of peptide release from the neurohumoral terminals of hypothalamic neurones

1979 • 217 citations

Estrogen Increases Proenkephalin Messenger Ribonucleic Acid Levels in the Ventromedial Hypothalamus of the Rat

1988 • 180 citations

μ and δ opioid receptors differentially couple to G protein subtypes in membranes of human neuroblastoma SH-SY5Y cells

1993 • 174 citations

Receptor‐mediated regulation of calcium channels and neurotransmitter release

1990 • 168 citations

Distribution of opioid peptides in the preoptic region: Immunohistochemical evidence for a steroid‐sensitive enkephalin sexual dimorphism

1988 • 135 citations

The distribution of neurotransmitter-specific cells and fibers in the anteroventral periventricular nucleus: Implications for the control of gonadotropin secretion in the rat

1987 • 120 citations

Gonadal Steroid Regulation of Substance P (SP) and SP-Encoding Messenger Ribonucleic Acids in the Rat Anterior Pituitary and Hypothalamus*

1990 • 117 citations

Evidence that decreased feeding induced by systemic injection of cholecystokinin is mediated by CCK-A receptors

1989 • 116 citations

Cellular localization of substance P‐ and neurokinin A‐encoding preprotachykinin mRna in the female rat brain

1989 • 115 citations

?-, ?-, and ?-opioid receptor agonists selectively modulate sexual behaviors in the female rat: Differential dependence on progesterone

1992 • 113 citations

Roles of second-messenger systems and neuronal activity in the regulation of lordosis by neurotransmitters, neuropeptides, and estrogen: A review

1994 • 109 citations

Concentrations of cholecystokinin, substance P, and bombesin in discrete regions of male and female rat brain: Sex differences and estrogen effects

1988 • 107 citations

Distribution of cholecystokinin‐immunoreactive cell bodies in the male and female rat: II. Bed nucleus of the stria terminalis and amygdala

1988 • 97 citations

Distribution of cholecystokinin‐immunoreactive cell bodies in the male and female rat: I. Hypothalamus

1987 • 95 citations

Estrogen regulates preproenkephalin-A mRNA levels in the rat ventromedial nucleus: temporal and cellular aspects

1995 • 89 citations

Changes in the pituitary and hypothalamic content of methionine-enkephalin during the estrous cycle of rats

1979 • 89 citations

Estrogen concentration by substance p‐immunoreactive neurons in the medial basal hypothalamus of the female rat

1988 • 85 citations

Regulation of lordosis behaviour in the female rat by corticotropin-releasing factor, β-endorphin/corticotropin and luteinizing hormone-releasing hormone neuronal systems in the medial preoptic area

1986 • 84 citations

Antinociceptive action of cholecystokinin octapeptide (CCK 8) and related peptides in rats and mice: Effects of naloxone and peptidase inhibitors

1987 • 83 citations

beta-Endorphin and met-enkephalins: their distribution, modulation by estrogens and haloperidol, and role in neuroendocrine control.

1980 • 82 citations

Facilitation of Lordosis by Injection of Substance P into the Midbrain Central Gray

1987 • 80 citations

Distribution of substance P‐immunoreactive elements in the preoptic area and the hypothalamus of the rat

1992 • 79 citations

Distribution of Neuropeptide Receptors

1995 • 76 citations

Selective activation of opioid receptors differentially affects lordosis behavior in female rats

1987 • 70 citations

Steroid regulation of calcitonin gene-related peptide mRNA expression in motoneurons of the spinal nucleus of the bulbocavernosus

1990 • 66 citations

Cholecystokinin stimulates and inhibits lordosis behavior in female rats

1987 • 66 citations

Biochemical characterization and autoradiographic localization of central substance P receptors using [125I]physalaemin

1985 • 58 citations

Analgesic activity of substance P in rats: Apparent mediation by met-enkephalin release

1982 • 57 citations

Estrogen Modulation of Opioid and Cholecystokinin Systems in the Limbic-Hypothalamic Circuit

1997 • 56 citations

Development of the Limbic-Hypothalamic Cholecystokinin Circuit: A Model of Sexual Differentiation. pp. 11–22

1992 • 56 citations

Injections of cholecystokinin into the ventromedial hypothalamic nucleus inhibit lordosis behavior in the rat

1988 • 55 citations

Chronic naltrexone treatment increases expression of preproenkephalin and preprotachykinin mRNA in discrete brain regions

1990 • 53 citations

The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration

1995 • 53 citations

Chronic naltrexone treatment increases expression of preproenkephalin and preprotachykinin mRNA in discrete brain regions.

1990 • 52 citations

A transcriptional enhancer essential for the expression of the rat cholecystokinin gene contains a sequence identical to the -296 element of the human c-fos gene.

1990 • 52 citations

Opiate-mediated inhibition of the release of cholecystokinin and substance P, but not neurotensin from cat hypothalamic slices

1982 • 51 citations

Induction of CCK mRNA levels in the limbic-hypothalamic circuit: Time course and site-specific effects of estrogen

1996 • 50 citations

Temporal regulation by estrogen of β-preprotachykinin mRNA expression in the rat ventromedial nucleus of the hypothalamus

1995 • 49 citations

Endogenous opioid‐immunoreactive neurons of the ventromedial hypothalamic nucleus concentrate estrogen in male and female rats

1991 • 48 citations

A substance P projection from the VMH to the dorsal midbrain central gray: Implication for lordosis

1990 • 46 citations

Microinjection of cholecystokinin into the medial preoptic nucleus facilitates lordosis behavior in the female rat

1989 • 44 citations

Sex difference in the substance P-immunoreactive innervation of the medial nucleus of the amygdala

1989 • 44 citations

G Proteins and the Mechanism of Action of Hormones, Neuretransmitters, and Autocrine and Paracrine Regulatory Factors

1990 • 44 citations

Gonadal steroid control of preprocholecystokinin mRNA expression in the limbic‐hypothalamic circuit: Comparison of adult with neonatal steroid treatments

1994 • 41 citations

Cholecystokinin gene expression in rat amygdaloid neurons: normal distribution and effect of morphine tolerance

1994 • 35 citations

Naltrexone facilitation of sexual receptivity in the rat

1985 • 33 citations

Evidence for an absence of estrogen‐concentration by CCK‐immunoreactive neurons in the hypothalamus of the female rat

1988 • 30 citations

The Central Pharmacology of Primary Afferents with Emphasis on the Disposition and Role of Primary Afferent Substance P

1986 • 29 citations

Distribution of preprocholecystokinin mRNA in motoneurons of the rat brainstem and spinal cord

1991 • 29 citations

Coexistence of substance P- and enkephalin-like peptides in single neurons of the rat hypothalamus

1987 • 28 citations

Procholecystokinin and proenkephalin A mRNA expression is modulated by cyclic AMP and noradrenaline

1990 • 24 citations

Differential regulation of α-calcitonin gene-related peptide and preprocholecystokinin messenger rna expression in α-motoneurons: Effects of testosterone and inactivity induced factors

1992 • 24 citations

Increase in hypothalamic cholecystokinin following acute and chronic morphine

1986 • 23 citations

Cholecystokinin and Pain

1987 • 20 citations

Effect of opiates on the release of cholecystokinin from in vitro hypothalamus and frontal cortex of Zucker lean (Fa/−) and obese (fa/fa) rats

1985 • 19 citations

Sex steroid regulation of hypothalamic opioid function

1995 • 18 citations

Morphine action on cholecystokinin octapeptide release from rat periaqueductal grey slices: Sensitisation by naloxone

1987 • 18 citations

Studies on the opiate receptor-mediated inhibition of K+-stimulated cholecystokinin and substance P release from cat hypothalamus in vitro

1984 • 17 citations

Sex steroid regulation of tachykinin peptides in neuronal circuitry mediating reproductive functions

1995 • 15 citations

Cholecystokinin (CCK)-like material and CCK mRNA levels in the rat brain and spinal cord after acute or repeated morphine treatment

1992 • 15 citations

Neuroanatomical Relationships of Substance P and Sex SteroidHormone—sensitive Neurons Involved in Sexual Behaviora

1991 • 9 citations

Modulation of substance P-ergic system in the rat spinal cord by an opioid antagonist

1994 • 6 citations