The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry

1984 • 2,580 citations

The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats

1977 • 2,494 citations

The formalin test: an evaluation of the method

1992 • 2,414 citations

The formalin test in mice: dissociation between inflammatory and non-inflammatory pain

1987 • 2,156 citations

A method for measurement of analgesic activity on inflamed tissue.

1957 • 1,558 citations

Endogenous Opioids: Biology and Function

1984 • 1,223 citations

Anatomy of CNS opioid receptors

1988 • 1,178 citations

Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons

1975 • 1,073 citations

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

1991 • 875 citations

Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo

1980 • 697 citations

Effects of substance P on functionally identified units in cat spinal cord

1976 • 655 citations

Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A.

1987 • 651 citations

Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section

1976 • 642 citations

The origin, distribution and synaptic relationships of substance P axons in rat spinal cord

1979 • 489 citations

Reexamination of the dorsal root projection to the spinal dorsal horn including observations on the differential termination of coarse and fine fibers

1979 • 465 citations

Molecular characterization of a functional cDNA for rat substance P receptor

1989 • 463 citations

Substance P: Depletion in the dorsal horn of rat spinal cord after section of the peripheral processes of primary sensory neurons

1979 • 455 citations

Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor binding

1988 • 435 citations

Release of substance P from the cat spinal cord.

1987 • 371 citations

Molecular Characterization of a Functional cDNA Encoding the Rat Substance P Receptor

1990 • 355 citations

The rat paw formalin test: comparison of noxious agents

1990 • 351 citations

Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues

1989 • 329 citations

Distribution of cells containing mRNAs encoding substance P and neurokinin B in the rat central nervous system

1988 • 316 citations

Cloning and expression of a rat neuromedin K receptor cDNA.

1990 • 308 citations

Differential activation of spinal cord dynorphin and enkephalin neurons during hyperalgesia: evidence using cDNA hybridization

1988 • 268 citations

Structure and gene organization of bovine neuromedin K precursor.

1986 • 230 citations

Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK ₁ ) Receptor Antagonist

1991 • 221 citations

Regional distribution of substance P, neurokinin α and neurokinin β in rat spinal cord, nerve roots and dorsal root ganglia, and the effects of dorsal root section or spinal transection

1985 • 211 citations

SUPPRESSION OF TRANSMISSION OF NOCICEPTIVE IMPULSES BY MORPHINE: SELECTIVE EFFECTS OF MORPHINE ADMINISTERED IN THE REGION OF THE SUBSTANTIA GELATINOSA

1977 • 195 citations

A noxious stimulus induces the preprotachykinin-A gene expression in the rat dorsal root ganglion: a quantitative study using in situ hybridization histochemistry

1988 • 191 citations

NK-1 and NK-3 type tachykinin receptor mRNA expression in the rat spinal cord dorsal horn is increased during adjuvant or formalin- induced nociception

1994 • 187 citations

Stereospecific effects of a nonpeptidic NK1 selective antagonist, CP-96,345: Antinociception in the absence of motor dysfunction

1991 • 175 citations

Factors governing release of methionine enkephalin-like immunoreactivity from mesencephalon and spinal cord of the cat in vivo.

1981 • 170 citations

Quantitative autoradiographic distribution of multiple neurokinin binding sites in rat spinal cord

1990 • 160 citations

Release of substance P from the spinal dorsal horn is enhanced in polyarthritic rats

1987 • 158 citations

Behavioral evidence that substance P may be a spinal cord sensory neurotransmitter

1981 • 156 citations

Lamina-specific Suppression of Dorsal-horn Unit Activity by Morphine Sulfate

1974 • 150 citations

Transneuronal labeling of spinal interneurons and sympathetic preganglionic neurons after pseudorabies virus injections in the rat medial gastrocnemius muscle

1992 • 143 citations

Novel substance P antagonist, CP-96,345, blocks responses of cat spinal dorsal horn neurons to noxious cutaneous stimulation and to substance P

1991 • 136 citations

Organization, structure, and expression of the gene encoding the rat substance P receptor

1991 • 123 citations

A cDNA encoding the precursor of the rat neuropeptide, neurokinin B

1987 • 112 citations

Spinal neurons exhibiting a specific nociceptive response receive abundant substance P-containing synaptic contacts.

1992 • 109 citations

Naloxone, naltrexone, and related noroxymorphones.

1973 • 107 citations

Effects of morphine on noxious stimuli-induced release of substance P from rabbit dorsal horn

1983 • 101 citations

Afferent fibers mediate the increase of met-enkephalin elicited in rat spinal cord by localized pain

1984 • 99 citations

CP-96,345, but not its stereoisomer, CP-96,344, blocks the nociceptive responses to intrathecally administered substance P and to noxious thermal and chemical stimuli in the rat

1993 • 94 citations

Selective inhibition of expression of the substance P receptor mRNA in pancreatic acinar AR42J cells by glucocorticoids.

1990 • 93 citations

Characterization of the effects produced by neurokinins and three agonists selective for neurokinin receptor subtypes in a spinal nociceptive reflex of the rat

1988 • 92 citations

Characterization of the hyperalgesic effect induced by intrathecal injection of substance P

1985 • 89 citations

Met-enkephalin and morphine but not dynorphin inhibit noxious stimuli-induced release of substance P from rabbit dorsal horn in situ

1985 • 88 citations

Inflammation-induced upregulation of NK1 receptor mRNA in dorsal horn neurones

1993 • 86 citations

‘Mirror pain’ in the formalin test: behavioral and 2-deoxyglucose studies

1993 • 83 citations

Increase in substance P in the dorsal horn during a chemogenic nociceptive stimulus

1985 • 82 citations

Release of substance P into the superficial dorsal horn following nociceptive activation of the hindpaw of the rat

1991 • 80 citations

Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain

1986 • 79 citations

Antiinflammatory and analgesic activity of a non-peptide substance P receptor antagonist

1992 • 74 citations

Intrathecal opioids block a spinal action of substance P in mice: Functional importance of both μ- and δ-receptors

1982 • 70 citations

Solution hybridization-nuclease protection assays for sensitive detection of differentially spliced substance P- and neurokinin A-encoding messenger ribonucleic acids

1989 • 62 citations

Polyclonal antibodies against the rat NK1 receptor

1992 • 49 citations

Subcutaneous formalin induces a segmental release of Met-enkephalin-like material from the rat spinal cord

1990 • 48 citations

In vivo tonic inhibition of spinal substance P (-like material) release by endogenous opioid(s) acting at δ receptors

1991 • 42 citations

Distinct antinociceptive actions mediated by different opioid receptors in the region of lamina I and laminae III‐V of the dorsal horn of the rat

1990 • 42 citations

Time course of the alteration in dorsal horn substance p levels following formalin: blockade by naloxone

1990 • 39 citations

Opioid and substance p receptor adaptations in the rat spinal cord following sub-chronic intrathecal treatment with morphine and naloxone

1993 • 33 citations

Lack of potent antinociceptive activity by substance P antagonist CP-96,345 in the rat spinal cord

1993 • 32 citations

Naloxone blocks the formalin-induced increase of substance P in the dorsal horn

1989 • 31 citations

KAPPA-/MU-receptor interactions in the opioid control of the in vivo release of substance P-like material from the rat spinal cord

1992 • 25 citations

Enkephalin-immunoreactive nociceptive neurons in the cat spinal cord

1992 • 22 citations

Inhibition by NK2 but not NK1 antagonists of carrageenan-induced preprodynorphin mRNA expression in rat dorsal horn laminal I neurons

1993 • 22 citations

The inhibitory effect of substance P antagonist, CP-96,345, on the late discharges of nociceptive neurons in the rat superficial spinal dorsal horn

1993 • 17 citations

Supraspinal inhibition of the two components of formalin-induced responses in rat dorsal horn neurons.

1989 • 8 citations