Antinociceptive action of cholecystokinin octapeptide (CCK 8) and related peptides in rats and mice: Effects of naloxone and peptidase inhibitors

A method for measurement of analgesic activity on inflamed tissue.

1957 • 1,558 citations

THE ABDOMINAL CONSTRICTION RESPONSE AND ITS SUPPRESSION BY ANALGESIC DRUGS IN THE MOUSE

1968 • 1,244 citations

THE EVALUATION OF THE ANALGESIC ACTION OF PETHIDINE HYDROCHLORIDE (DEMEROL)

1944 • 1,032 citations

Immunochemical studies on cholecystokinin. II. Distribution and molecular heterogeneity in the central nervous system and small intestine of man and hog.

1978 • 805 citations

New peptide in the vertebrate CNS reacting with antigastrin antibodies

1975 • 749 citations

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

1980 • 705 citations

The quantitative measurement of motor inco-ordination in naive mice using an accelerating rotarod

1968 • 539 citations

The inhibitory effect of fentanyl and other morphine-like analgesics on the warm water induced tail withdrawl reflex in rats.

1963 • 537 citations

On the central sites for the antinociceptive action of morphine and fentanyl

1970 • 265 citations

Inhibition of spontaneous and opiate-modified nociception by an endogenous neuropeptide with Phe-Met-Arg-Phe-NH2-like immunoreactivity.

1984 • 213 citations

Analgesia and ptosis caused by caerulein and cholecystokinin octapeptide (CCK-8)

1980 • 211 citations

Caerulein and cholecystokinin suppress β-endorphin-induced analgesia in the rat

1982 • 195 citations

Separate involvement of the spinal noradrenergic and serotonergic systems in morphine analgesia: the differences in mechanical and thermal algesic tests

1983 • 185 citations

Antinociceptive effect of centrally administered caerulein and cholecystokinin octapeptide (CCK-8)

1981 • 181 citations

Opiate receptors in mice: Genetic differences

1975 • 171 citations

Bombesin: Receptor distribution in brain and effects on nociception and locomotor activity

1980 • 169 citations

New vertebrate brain–gut peptide related to a molluscan neuropeptide and an opioid peptide

1981 • 157 citations

A comparison of the antinociceptive responses to the GABA-receptor agonists THIP and baclofen

1985 • 151 citations

Studies on the location and release of cholecystokinin and vasoactive intestinal peptide in rat and cat spinal cord

1982 • 147 citations

Increase in potencies of opioid peptides after peptidase inhibition

1983 • 143 citations

Coexistence of cholecystokinin- and substance P-like peptides in neurons of the dorsal root ganglia of the rat

1982 • 142 citations

Inhibition of enkepha,in metabolism by, and antinociceptive activity of, bestatin, an aminopeptidase inhibitor

1983 • 139 citations

Unsulfated C-terminal 7-peptide of cholecystokinin: A new ligand of the opiate receptor

1978 • 131 citations

Evidence for cholecystokinin-like immunoreactive neurons in the rat medulla oblongata which project to the spinal cord

1984 • 109 citations

Cholecystokinin octapeptide excites dorsal horn neurons both in vivo and in vitro

1981 • 106 citations

Neurotensin-induced antinociception in mice: antagonism by thyrotropin-releasing hormone.

1981 • 106 citations

A mechanism for the analgesic effect of neurotensin as revealed by behavioral and electrophysiological techniques

1984 • 100 citations

Mammalian neuronal actions of FMRFamide and the structurally related opioid Met-enkephalin- Arg6-Phe7

1982 • 99 citations

Evidence for periaqueductal cholecystokinin-substance P neurons projecting to the spinal cord

1983 • 93 citations

Blood-brain barrier permeability to peptides: Pitfalls in measurement

1981 • 88 citations

Degradation of cholecystokinin-like peptides by a crude rat brain synaptosomal fraction: A study by high pressure liquid chromatography

1981 • 86 citations

Basic and Regulatory Mechanisms of In Vitro Release of Met‐Enkephalin from the Dorsal Zone of the Rat Spinal Cord

1984 • 83 citations

Proglumide prevents and curtails acute tolerance to morphine in rats

1984 • 80 citations

Immunohistochemical studies of FMRF-amide-like immunoreactivity in rat brain

1983 • 77 citations

Distribution of neuropeptide Y-like immunoreactivity and its relationship to FMRF-amide-like immunoreactivity in the sixth lumbar and first sacral spinal cord segments of the rat

1985 • 75 citations

Cholecystokinin in the rat spinal cord: distribution and lack of effect of neonatal capsaicin treatment and rhizotomy

1982 • 68 citations

Opiate analgesia: Evidence for circadian rhythms in mice

1982 • 58 citations

Facilitation of GABA release by cholecystokinin and caerulein in rat cerebral cortex

1983 • 56 citations

Studies on Algesimetry by Electrical Stimulation of the Mouse Tail

1961 • 48 citations

Reversal of Antinociceptive Effect of Cholecystokinin by Benzodiazepines and a Benzodiazepine Antagonist, Ro 15-1788

1985 • 48 citations

Rapid Induction by Acetylcholine, Bradykinin and Potassium of a Nociceptive Response in Mice and its Selective Antagonism by Aspirin

1964 • 41 citations

The Effects of Cholecystokinin‐8 in the Nucleus Tractus Solitarius

1985 • 35 citations

The effects of opioid and FMRF-amide peptides on thermal behavior in the snail

1985 • 34 citations

Effect of cholecystokinin octapeptide and ceruletide on release of acetylcholine from cerebral cortex of the rat in vivo

1984 • 34 citations

Cholecystokinin octa- and tetrapeptide degradation by synaptic membranes. I. Evidence for competition with enkephalins for in vitro common degradation pathways

1981 • 33 citations

Actions of Cholecystokinin Octapeptide on Rat Spinal Dorsal Horn Neuronsa

1985 • 32 citations

Central effects of ceruletide analogues

1981 • 32 citations

Cholecystokinin octa- and tetrapeptide degradation by synaptic membranes. II. Solubilization and separation of membrane-bound CCK-8 cleaving enzymes

1983 • 31 citations

Effect of ceruletide on rest pain in patients with arterial insufficiency of the lower extremity

1982 • 31 citations

Antistereotypic effects of cholecystokinin octapeptide (cck-8), ceruletide and related peptides on apomorphine-induced gnawing in sensitized mice

1985 • 30 citations

The effects of C-terminal fragments of cholecystokinin on the firing of single neurones in the caudal trigeminal nucleus of the rat

1982 • 27 citations

Reversal of the antinociceptive effects of centrally-administered morphine by the benzodiazepine receptor antagonist Ro 15-1788

1984 • 24 citations

Met-Enkephalin-Arg6-Phe7-like immunoreactive substances mediate electroacupuncture analgesia in the periaqueductal gray of the rabbit

1984 • 21 citations

Enantiomers of [R,S]-thiorphan: Dissociation of analgesia from enkephalinase a inhibition

1985 • 20 citations

Cholecystokinin octa- and tetrapeptide degradation by synaptic membranes. III. Inactivation of CCK-8 by a phosphoramidon-sensitive endopeptidase

1984 • 19 citations

Cholecystokinin octapeptide (CCK-8), ceruletide and analogues of ceruletide: Effects on tremors induced by oxotremorine, harmine and ibogaine a comparison with prolyl-leucylglycine amide (MIF), anti-parkinsonian drugs and clonazepam

1983 • 18 citations

Further evidence that substance P partly mediates the action of cholecystokinin octapeptide (CCK-8) on the guinea pig ileum but not gall bladder: Studies with a substance P antagonist

1984 • 15 citations

Caerulein and Morphine: an Attempt to Differentiate Their Antinociceptive Effects

1982 • 14 citations

Apomorphine separates the antinociceptive effects of cholecystokinin octapeptide and ceruletide from those of morphine

1983 • 14 citations

Endogenous Opioids and Pain: A Review

1981 • 12 citations

Antagonism of Cholecystokinin by Naloxone and Proglumide in Mice

1985 • 11 citations

Effect of bestatin and thiorphan on [Met5]enkephalin-Arg6-Phe7-induced analgesia

1984 • 11 citations

A calorigenic effect of imipramine in the mouse?

1969 • 5 citations

Endorphin releasers: A new possible approach to the treatment of pain after burns—a preliminary report

1983 • 5 citations