How Tumor Cells Make Use of CD44

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

1991 • 1,685 citations

The proximo‐distal sequence of origin of the parts of the chick wing and the role of the ectoderm

1948 • 1,101 citations

Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons.

1992 • 1,040 citations

CD44: Structure, Function and Association with the Malignant Process

1997 • 1,004 citations

T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-lβ

1993 • 896 citations

Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse

1992 • 676 citations

FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb

1993 • 660 citations

Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development

1996 • 588 citations

Requirement for CD44 in Activated T Cell Extravasation into an Inflammatory Site

1997 • 560 citations

Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85-95-kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells.

1987 • 554 citations

CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor.

1995 • 434 citations

Participation in Normal Immune Responses of a Metastasis-Inducing Splice Variant of CD44

1992 • 417 citations

The hyaluronan receptor (CD44) participates in the uptake and degradation of hyaluronan.

1992 • 399 citations

Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein.

1994 • 384 citations

CD44 Regulates Hematopoietic Progenitor Distribution, Granuloma Formation, and Tumorigenicity

1997 • 380 citations

Identification of hyaluronic acid binding sites in the extracellular domain of CD44

1993 • 370 citations

CD44 variant exon epitopes in primary breast cancer and length of survival

1995 • 363 citations

Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins

1994 • 319 citations

Distinct effects of two CD44 isoforms on tumor growth in vivo.

1991 • 315 citations

Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44.

1993 • 309 citations

Splicing choice from ten variant exons establishes CD44 variability

1993 • 291 citations

Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation.

1997 • 270 citations

Biochemical properties of glycoproteins involved in lymphocyte recognition of high endothelial venules in man.

1988 • 257 citations

Glycosylation of CD44 negatively regulates its recognition of hyaluronan.

1995 • 255 citations

Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon.

1995 • 253 citations

Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated adhesion function.

1994 • 249 citations

Multiple variants of the human lymphocyte homing receptor CD44 generated by insertions at a single site in the extracellular domain.

1992 • 236 citations

CD44 variant isoforms in non-Hodgkin's lymphoma: a new independent prognostic factor

1995 • 230 citations

The two major CD44 proteins expressed on a metastatic rat tumor cell line are derived from different splice variants: each one individually suffices to confer metastatic behavior.

1993 • 223 citations

Variant cell lines selected for alterations in the function of the hyaluronan receptor CD44 show differences in glycosylation.

1995 • 196 citations

Signaling through CD44 Is Mediated by Tyrosine Kinases

1996 • 189 citations

Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan.

1996 • 187 citations

An Essential Role for CD44 Variant Isoforms in Epidermal Langerhans Cell and Blood Dendritic Cell Function

1997 • 176 citations

AP-1-Mediated Invasion Requires Increased Expression of the Hyaluronan Receptor CD44

1997 • 170 citations

A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth

1998 • 167 citations

Coupling of signal transduction to alternative pre-mRNA splicing by a composite splice regulator

1998 • 162 citations

Regulation of CD44 binding to hyaluronan by glycosylation of variably spliced exons.

1995 • 154 citations

A link between ras and metastatic behavior of tumor cells: ras induces CD44 promoter activity and leads to low-level expression of metastasis-specific variants of CD44 in CREF cells.

1993 • 148 citations

Regulated clustering of variant CD44 proteins increases their hyaluronate binding capacity.

1996 • 144 citations

Post-translational protein modification and expression of ankyrin-binding site(s) in GP85 (Pgp-1/CD44) and its biosynthetic precursors during T-lymphoma membrane biosynthesis.

1991 • 134 citations

Molecular cloning and expression of Pgp-1. The mouse homolog of the human H-CAM (Hermes) lymphocyte homing receptor.

1989 • 133 citations

Inhibition of tumor growth in vivo with a soluble CD44-immunoglobulin fusion protein.

1992 • 126 citations

Lymph node (but not spleen) invasion by murine lymphoma is both CD44- and hyaluronate-dependent.

1995 • 113 citations

Variant Exons v6 and v7 Together Expand the Repertoire of Glycosaminoglycans Bound by CD44

1997 • 95 citations

Hyaluronate-independent metastatic behavior of CD44 variant-expressing pancreatic carcinoma cells.

1996 • 93 citations

Expression of CD44 isoforms carrying metastasis-associated sequences in newborn and adult rats

1993 • 43 citations

Cd44 and Splice Variants of Cd44 in Normal Differentiation and Tumor Progression

1993 • 30 citations

Keratinocyte growth factor is a bifunctional regulator of HPV16 DNA-immortalized cervical epithelial cells.

1995 • 20 citations

CD44 variant exon v5 encodes a tyrosine that is sulphated

1998 • 17 citations

Tumour necrosis factor increases tumour uptake of Co-administered antibody-carboxypeptidase G2 conjugate

1993 • 15 citations

A Splice Variant of CD44 Expressed in the Rat Apical Ectodermal Ridge Contributes to Limb Outgrowth

1996 • 14 citations