Differentiation of Resting Human Peripheral Blood γδ T Cells toward Th1- or Th2-Phenotype

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

The Th1/Th2 paradigm

1997 • 1,102 citations

Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

1995 • 672 citations

Nonpeptide ligands for human gamma delta T cells.

1994 • 373 citations

Recognition by Human V _γ 9/V _δ 2 T Cells of a GroEL Homolog on Daudi Burkitt's Lymphoma Cells

1990 • 357 citations

Differential ability of T_h1 and T_h2 T cells to express Fas ligand and to undergo activation-induced cell death

1994 • 329 citations

Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam.

1995 • 179 citations

The primary response of human gamma/delta + T cells to Mycobacterium tuberculosis is restricted to V gamma 9-bearing cells.

1991 • 173 citations

T cell receptor/CD3-signaling induces death by apoptosis in human T cell receptor gamma delta + T cells.

1991 • 167 citations

Proteoglycan (Aggrecan)-Induced Arthritis in BALB/c Mice Is a Th1-Type Disease Regulated by Th2 Cytokines

1999 • 144 citations

Single-cell cytokine analysis of gamma delta T cell responses to nonpeptide mycobacterial antigens.

1997 • 141 citations

TH1/TH2,3 Imbalance due to Cytokine‐Producing NK, γδ T and NK‐γδ T Cells in Murine Pregnancy Decidua in Success or Failure of Pregnancy

2001 • 106 citations

Primary gamma delta cell clones can be defined phenotypically and functionally as Th1/Th2 cells and illustrate the association of CD4 with Th2 differentiation.

1998 • 105 citations

IL-15 enhances the response of human gamma delta T cells to nonpeptide [correction of nonpetide] microbial antigens.

1998 • 96 citations

Primary activation of V gamma 9-expressing gamma delta T cells by Mycobacterium tuberculosis. Requirement for Th1-type CD4 T cell help and inhibition by IL-10.

1994 • 94 citations

Neutralizing IL-12 during induction of murine acute graft-versus-host disease polarizes the cytokine profile toward a Th2-type alloimmune response and confers long term protection from disease.

1997 • 92 citations

Regulation of Human CD4⁺αβ T-Cell-Receptor-Positive (TCR⁺) and γδ TCR⁺T-Cell Responses toMycobacterium tuberculosisby Interleukin-10 and Transforming Growth Factor β

1999 • 92 citations

IL-15 Enhances the Response of Human γδ T Cells to Nonpetide Microbial Antigens

1998 • 85 citations

Primary γδ Cell Clones Can Be Defined Phenotypically and Functionally as Th1/Th2 Cells and Illustrate the Association of CD4 with Th2 Differentiation

1998 • 79 citations

Dominance of IL-12 Over IL-4 in γδ T Cell Differentiation Leads to Default Production of IFN-γ: Failure to Down-Regulate IL-12 Receptor β2-Chain Expression

2000 • 79 citations

Comparative analysis of αβ and γδ T cell activation by Mycobacterium tuberculosis and isopentenyl pyrophosphate

1997 • 74 citations

Increase of gamma/delta T cells in hospital workers who are in close contact with tuberculosis patients

1994 • 72 citations

Synovial fluid T cell clones from oligoarticular juvenile arthritis patients display a prevalent Th1/Th0-type pattern of cytokine secretion irrespective of immunophenotype

1997 • 61 citations

Differential Regulation of IFN-γ, TNF-α, and IL-10 Production by CD4+ αβTCR+ T Cells and Vδ2+ γδ T Cells in Response to Monocytes Infected with Mycobacterium tuberculosis-H37Ra

1999 • 51 citations

Patterns of Phosphoantigen Stimulation of Human Vγ9/Vδ2 T Cell Clones Include Th0 Cytokines

1997 • 42 citations

Regulation by cytokines (IL-12, IL-15, IL-4 and IL-10) of the Vγ9Vδ2 T cell response to mycobacterial phosphoantigens in responder and anergic HIV-infected persons

1999 • 33 citations

Functional Inactivation in the Whole Population of Human Vγ9/Vδ2 T Lymphocytes Induced By a Nonpeptidic Antagonist

1997 • 29 citations

γδ T cell activation or anergy during infections: the role of nonpeptidic TCR ligands and HLA class I molecules

1997 • 28 citations

Activation of human gamma delta T cells by Mycobacterium tuberculosis and Daudi lymphoma cells: differential regulatory effect of IL-10 and IL-12.

1997 • 22 citations

Human γδ T lymphocytes in HIV disease: effector functions and control by natural killer cell receptors

2000 • 15 citations

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