Lipid flow in bile formation

Progress in Unraveling Pathways of Golgi Traffic

1985 • 615 citations

Lipid Traffic in Animal Cells

1989 • 468 citations

The liver: quantitative aspects of structure and function

1973 • 369 citations

The liver: Biology and pathobiology

1988 • 312 citations

Preferential Utilization of Free Cholesterol From High-Density Lipoproteins for Biliary Cholesterol Secretion in Man

1978 • 300 citations

Biliary lipid output during three meals and an overnight fast. I. Relationship to bile acid pool size and cholesterol saturation of bile in gallstone and control subjects.

1975 • 245 citations

Biochemistry of bile secretion

1987 • 221 citations

Multicompartmental Analysis of Cholesterol Metabolism in Man

1978 • 218 citations

Membranes and bile formation. Composition of several mammalian biles and their membrane-damaging properties

1979 • 210 citations

The liver and IgA: Immunological, cell biological and clinical implications

1989 • 177 citations

Micellar theory of biliary cholesterol excretion

1972 • 164 citations

Studies in the biosynthesis of hepatic and biliary lecithins

1967 • 164 citations

Mechanism of secretion of biliary lipids: Role of a microtubular system in hepatocellular transport of biliary lipids in the rat

1978 • 137 citations

Role of the hepatocyte microtubular system in the excretion of bile salts and biliary lipid: implications for intracellular vesicular transport.

1988 • 130 citations

Regulation of biliary cholesterol output in the rat: dissociation from the rate of hepatic cholesterol synthesis, the size of the hepatic cholesteryl ester pool, and the hepatic uptake of chylomicron cholesterol.

1979 • 118 citations

Specific pools of phospholipids are used for lipoprotein secretion by cultured rat hepatocytes.

1986 • 118 citations

Regulation of biliary cholesterol secretion in the rat. Role of hepatic cholesterol esterification.

1984 • 116 citations

Origin of biliary cholesterol and lecithin in the rat: contribution of new synthesis and preformed hepatic stores.

1982 • 114 citations

Na+-H+ exchanger of human placental brush-border membrane: identification and characterization

1986 • 111 citations

Tauroursodeoxycholate prevents taurocholate induced cholestasis

1982 • 105 citations

Hepatotoxic bile acids increase cytosolic Ca++ activity of isolated rat hepatocytes

1988 • 104 citations

The contribution of newly synthesized cholesterol to biliary cholesterol in the rat.

1981 • 103 citations

Influence of colchicine and phalloidin on bile secretion and hepatic ultrastructure in the rat. Possible interaction between microtubules and microfilaments.

1980 • 102 citations

Kinetic analysis of biliary lipid excretion in man and dog.

1976 • 100 citations

Lecithin fatty acid composition in bile and plasma of man, dogs, rats, and oxen

1965 • 98 citations

The effects of colchicine on secretion into bile of bile salts, phospholipids, cholesterol and plasma membrane enzymes: bile salts are secreted unaccompanied by phospholipids and cholesterol

1984 • 97 citations

Alterations in hepatic pericanalicular cytoplasm during enhanced bile secretory activity.

1979 • 97 citations

Ultracentrifugal isolation of vesicular carriers of biliary cholesterol in native human and rat bile

1987 • 94 citations

Influence of colchicine and phalloidin on bile secretion and hepatic ultrastructure in the rat

1980 • 93 citations

Bile acids and lipid metabolism. 3. Influence of bile acids on phospholipids in liver and bile of the isolated perfused dog liver.

1968 • 92 citations

Secretory Vesicle-Associated Proteins and Their Role in Exocytosis

1990 • 90 citations

Transcytosis and paracellular movements of horseradish peroxidase across liver parenchymal tissue from blood to bile. Effects of alpha-naphthylisothiocyanate and colchicine

1985 • 89 citations

Taurocholate stimulates transcytotic vesicular pathways labeled by horseradish peroxidase in the isolated perfused rat liver

1990 • 88 citations

Regulation of biliary cholesterol secretion. Functional relationship between the canalicular and sinusoidal cholesterol secretory pathways in the rat.

1988 • 88 citations

Phospholipid, cholesterol, polypeptide and glycoprotein composition of hepatic endosome subfractions

1985 • 83 citations

Mechanism of secretion of biliary lipids. I. Role of bile canalicular and microsomal membranes in the synthesis and transport of biliary lecithin and cholesterol.

1975 • 81 citations

The effect of sodium taurocholate on the hepatic metabolism of sulfobromophthalein sodium (BSP). The role of bile flow

1970 • 80 citations

Role of membranes in bile formation. Comparison of the composition of bile and a liver bile-canalicular plasma-membrane subfraction

1976 • 76 citations

Rapid kinetic analysis of the bile-salt-dependent secretion of phospholipid, cholesterol and a plasma-membrane enzyme into bile

1984 • 74 citations

Tubulovesicular Transcytotic Pathway in Isolated Rat Hepatocyte Couplets in Culture

1988 • 74 citations

Alteration of the Degree of Biliary Cholesterol Saturation in the Hamster and Rat by Manipulation of the Pools of Preformed and Newly Synthesized Cholesterol

1983 • 73 citations

The effect of bile salts upon lecithin synthesis.

1971 • 73 citations

High performance liquid chromatographic analysis of molecular species of phosphatidylcholine — development of quantitative assay and its application to human bile

1983 • 72 citations

Lipid transfer proteins

1990 • 71 citations

Intracellular Lipid Transport in Eukaryotes

1987 • 70 citations

Subfractionation of hepatic endosomes in Nycodenz gradients and by free-flow electrophoresis. Separation of ligand-transporting and receptor-enriched membranes

1985 • 70 citations

Trends in bile acid research

1990 • 69 citations

Fatty acid composition of phospholipids in bile in man: Promoting effect of deoxycholate on arachidonate

1987 • 68 citations

Effects of cytochalasin D and colchicine on the uptake, translocation, and biliary secretion of horseradish peroxidase and [14C]sodium taurocholate in the rat

1983 • 66 citations

Biliary protein output by isolated perfused rat livers. Effects of bile salts

1983 • 64 citations

The uncoupling of biliary lipid from bile acid secretion by organic anions in the rat

1990 • 62 citations

In vitro effect of free bile acids on the bile canaliular membrane phospholipids in the rat

1976 • 62 citations

Concentrative biliary secretion of ceftriaxone

1990 • 61 citations

Serial quantitative image analysis and confocal microscopy of hepatic uptake, intracellular distribution and biliary secretion of a fluorescent bile acid analog in rat hepatocyte doublets

1990 • 60 citations

Separation of phospholipid molecular species by high performance liquid chromatography: potentials for use in metabolic studies.

1986 • 60 citations

Bile acids and lipid metabolism

1968 • 58 citations

Effect of taurochenodeoxycholate or tauroursodeoxycholate upon biliary output of phospholipids and plasma-membrane enzymes, and the extent of cell damage, in isolated perfused rat livers

1983 • 57 citations

Influence of cholic and chenodeoxycholic acid on biliary cholesterol secretion in man

1977 • 57 citations

Role of ATP in respiratory control and active transport in tobacco hornworm midgut

1980 • 56 citations

Inhibition of biliary phospholipid and cholesterol secretion by bilirubin in the Sprague-Dawley and Gunn rat

1984 • 56 citations

Biosynthesis of molecular species of phosphatidylcholines in bile, liver and plasma of rats given [1,1-2H2]ethanol

1974 • 56 citations

Praziquantel: mode of action

1987 • 54 citations

The calcium ionophore A23187 increases the tight-junctional permeability in rat liver

1988 • 54 citations

Biosynthesis and turnover of individual molecular species of phosphatidylcholine in liver and bile

1980 • 52 citations

Effect of Organic Anions on Biliary Lipids in the Rat

1982 • 51 citations

Hepatic handling of bile salts and protein in the rat during intrahepatic cholestasis

1983 • 51 citations

Inappropriate hepatic cholesterol synthesis expands the cellular pool of sterol available for recruitment by bile acids in the rat.

1989 • 49 citations

Effects of chronic choleretic infusions of bile acids on the membrane of the bile canaliculus. A biochemical and morphologic study.

1977 • 49 citations

Effect of pravastatin on biliary lipid composition and bile acid synthesis in familial hypercholesterolaemia.

1990 • 48 citations

Bile Salt Hydrophobicity Influences Cholesterol Recruitment From Rat Liver In Vivo When Cholesterol Synthesis and Lipoprotein Uptake Are Constant

1988 • 48 citations

Phospholipid lamellae are cholesterol carriers in human bile

1990 • 48 citations

Sodium valproate inhibits the movement of secretory vesicles in rat hepatocytes

1988 • 47 citations

Current concepts of biliary secretion

1989 • 47 citations

Metabolism of free and esterified cholesterol and apolipoproteins of plasma low and high density lipoproteins

1980 • 46 citations

Dissociation of hepatic cholesterol synthesis from hepatic low-density lipoprotein uptake and biliary cholesterol saturation in female and male hamsters of different ages

1983 • 46 citations

Ampicillin inhibits biliary cholesterol secretion

1985 • 45 citations

Biliary lipid secretion in the rat during infusion of increasing doses of unconjugated bile acids

1987 • 44 citations

Mathematical model of biliary lipid secretion: a quantitative analysis of physiological and biochemical data from man and other species.

1984 • 43 citations

Proceedings of the Physiological Society, 17–18 December 1971, Nottingham Meeting: Communications

1972 • 43 citations

Biliary transport maximum of tauroursodeoxycholate is twice as high as that of taurocholate in the rat

1981 • 41 citations

Liver Cell Plasma Membrane Lipids and the Origin of Biliary Phospholipid

1975 • 41 citations

Early Structural and Functional Changes in Liver of Rats Treated with a Single Dose of Valproic Acid

1984 • 40 citations

Effect of complete sulfation of bile acids on bile formation in rats

1987 • 40 citations

Modulation of low density lipoprotein receptor activity by bile acids: differential effects of chenodeoxycholic and ursodeoxycholic acids in the hamster

1987 • 39 citations

Effect of dietary cholesterol on phosphatidylcholines and phosphatidylethanolamines in bile and gallbladder mucosa in the prairie dog

1989 • 38 citations

Demonstration of a Transcellular Vesicle Pathway for Biliary Excretion of Inulin in Rat Liver

1986 • 36 citations

The bile salt secretory polarity of hepatocytes

1989 • 35 citations

Monohydroxy bile salt sulfates: Tauro-3β-hydroxy-5-cholenoate-3-sulfate induces intrahepatic cholestasis in rats

1983 • 34 citations

Effects of dietary fish oil on biliary phospholipids and prostaglandin synthesis in the cholesterol‐fed pairie dog

1990 • 34 citations

Effect of bean intake on biliary lipid secretion and on hepatic cholesterol metabolism in the rat.

1989 • 33 citations

The phospholipids of ruminant bile

1963 • 31 citations

Effects of interruption of enterohepatic circulation on biliary lipid secretion in man

1978 • 31 citations

The transport of lipoprotein cholesterol into bile: a reassessment of kinetic studies in the experimental animal

1989 • 30 citations

Cell Kinetics and Secretion of Mucus in the Gastrointestinal Mucosa, and Their Diurnal Rhythm

1988 • 29 citations

The effect of a rat plasma high‐density lipoprotein subfraction on the synthesis of bile salts by rat hepatocyte monolayers

1985 • 29 citations

Effect of ML-236b (compactin) on biliary excretion of bile salts and lipids, and on bile flow, in the rat

1984 • 28 citations

Studies on the origin of biliary phospholipid. Effect of dehydrocholic acid and cholic acid infusions on hepatic and biliary phospholipids

1990 • 27 citations

Control of biliary phospholipid secretion. Effect of continuous and discontinuous infusion of taurocholate on biliary phospholipid secretion

1986 • 27 citations

Interindividual variability in biliary excretion of ceftriaxone: effects on biliary lipid metabolism and on intestinal microflora

1988 • 27 citations

Bile canalicular contraction in the isolated hepatocyte doublet is related to an increase in cytosolic free calcium ion concentration

1988 • 27 citations

Ampicillin inhibits the movements of biliary secretory vesicles in rat hepatocytes

1988 • 27 citations

Biliary lipid secretion in the rat. The uncoupling of biliary cholesterol and phospholipid secretion from bile acid secretion by sulfated glycolithocholic acid

1987 • 27 citations

Dissociation of bile flow and biliary lipid secretion from biliary lysosomal enzyme output in experimental cholestasis.

1981 • 26 citations

Inhibition of biliary phospholipid and cholesterol secretion by cefoperazone

1987 • 25 citations

Influence of tauroursodeoxycholic and taurodeoxycholic acids on hepatic metabolism and biliary secretion of phosphatidylcholine in the isolated rat liver

1986 • 25 citations

Transcellular transport of organic anions in the isolated perfused rat liver: The differential effects of monensin and colchicine

1991 • 25 citations

Abnormal secretion of proteins into bile from colchicine-treated isolated perfused rat livers

1983 • 24 citations

The influence of taurocholate and dehydrocholate choleresis on plasma disappearance and biliary excretion of indocyanine green in the rat

1974 • 23 citations

Compartmentalization of cholesterol in hepatic and intestinal cells: implications for bile and lipoprotein secretion

1987 • 22 citations

Selective biliary lipid secretion at low bile-salt-output rates in the isolated perfused rat liver. Effects of phalloidin

1986 • 21 citations

Cholestasis induced by Sulphated Glycolithocholic Acid in the Rat: Protection by Endogenous Bile Acids

1985 • 21 citations

Incorporation of plasma free fatty acids into bile lipids in man

1967 • 21 citations

Quantitation of phospholipid vesicles and their cholesterol content in human bile by quasi-elastic light scattering

1988 • 20 citations

Retrograde intrabiliary injection of amphipathic materials causes phospholipid secretion into bile. Taurocholate causes phosphatidylcholine secretion, 3-[(3-cholamidopropyl)dimethylammonio]-propane-1-sulphonate (CHAPS) causes mixed phospholipid secretion

1989 • 20 citations

Biliary Inter-Relationship between Phospholipid, Bilirubin and Taurocholate in the Anaesthetized Rat

1984 • 20 citations

Inhibition of biliary cholesterol and phospholipid secretion during cyclobutyrol-induced hydrocholeresis

1989 • 18 citations

Biliary lipid secretion and its control. Effect of taurodehydrocholate

1987 • 18 citations

The relationship between HDL-, LDL-, liposomes-free cholesterol, biliary cholesterol and bile salts in the rat

1987 • 18 citations

Effect of ioglycamide (Biligram) on bile flow and biliary lipid secretion in man.

1978 • 18 citations

Biliary secretion of phosphatidylcholine and its molecular species in cholecystectomized T-tube patients: Effects of bile acid hydrophilicity

1986 • 17 citations

BILE ACIDS IN HEALTH AND DISEASE

1987 • 17 citations

Inhibitory action of cyclobutyrol on the secretion of biliary cholesterol and phospholipids

1990 • 17 citations

Bile lipid secretion in isolated perfused rat liver. A model for metabolic studies

1987 • 16 citations

Origin of biliary phosphatidylcholines studied by coenzyme labelling with [1,1-2H2]ethanol

1983 • 16 citations

Glycerophospholipids and cholesterol composition of bile in bile-fistula rats treated with monensin

1990 • 15 citations

Output of lysosomal contents and cholesterol into bile can be stimulated by taurodehydrocholate

1987 • 15 citations

Processing of cholesteryl ester from low-density lipoproteins in the rat. Hepatic metabolism and biliary secretion after uptake by different hepatic cell types

1989 • 14 citations

Phospholipid degradation in, and protein content of, rat fistula bile

1986 • 12 citations

Bile Acids Inhibit Secretion of Very Low Density Lipoprotein by Rat Hepatocytes

1987 • 10 citations

Modulation of biliary lipid secretion by forskolin and cyclic AMP analogues

1990 • 10 citations

Effect of Phalloidin on Biliary Lipid Secretion in Rats

1980 • 8 citations

Quantification of LDL cholesteryl ester contribution to biliary steroids in the rat

1986 • 8 citations

Basal and bile salt-stimulated bile flow and biliary lipid excretion in ponies.

1989 • 7 citations

Menadione increases hepatic tight-junctional permeability. Its effect can be decreased by butylated hydroxytoluene and verapamil

1990 • 7 citations

Hormonal Control of Biliary Lipid Secretion in Dogs

1983 • 7 citations

Effect of streptozotocin-induced diabetes on sex differences in biliary lipid secretion in the rat

1990 • 6 citations

Biliary Cholesterol - Friend or Foe?

1986 • 6 citations

Effects of dibutyryl cyclic AMP and theophylline on biliary cholesterol secretion

1984 • 5 citations

Glucagon lowers canine biliary cholesterol output at physiologic doses

1986 • 5 citations

Inhibition of biliary phospholipid secretion by bilirubin in partially hepatectomized rats

1987 • 4 citations

Pulmonary changes after endoscopic injection sclerotherapy of esophageal variances - am experimental study

1986 • 1 citations