The chymotrypsin inhibitor carbobenzyloxy-leucine-tyrosine-chloromethylketone interferes with phospholipase D activation induced by formyl-methionyl-leucyl-phenylalanine in human neutrophils

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activation.

1990 • 435 citations

Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils

1989 • 429 citations

Activation of NADPH-dependent superoxide production in a cell-free system by sodium dodecyl sulfate.

1985 • 356 citations

Mechanism of neutrophil activation by NAF, a novel monocyte‐derived peptide agonist

1988 • 320 citations

Activation of human neutrophil nicotinamide adenine dinucleotide phosphate, reduced (triphosphopyridine nucleotide, reduced) oxidase by arachidonic acid in a cell-free system.

1985 • 315 citations

Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes.

1988 • 307 citations

Stimulated neutrophils from patients with autosomal recessive chronic granulomatous disease fail to phosphorylate a Mr-44,000 protein

1985 • 286 citations

Protein kinase C and the activation of the human neutrophil NADPH- oxidase

1987 • 268 citations

Activation of the respiratory burst enzyme in human polymorphonuclear leukocytes by chemoattractants and other soluble stimuli. Evidence that the same oxidase is activated by different transductional mechanisms.

1983 • 225 citations

Activation of a NADPH Oxidase From Horse Polymorphonuclear Leukocytes in a Cell- Free System

1984 • 221 citations

Activation of human neutrophil phospholipase D by three separable mechanisms

1990 • 220 citations

Lipopolysaccharide priming of human neutrophils for an enhanced respiratory burst. Role of intracellular free calcium.

1989 • 213 citations

Turning on the respiratory burst

1990 • 211 citations

The O2(-) -forming oxidase responsible for the respiratory burst in human neutrophils. Properties of the solubilized enzyme.

1979 • 210 citations

Phospholipase D activation is functionally linked to superoxide generation in the human neutrophil

1989 • 204 citations

Two transduction sequences are necessary for neutrophil activation by receptor agonists.

1988 • 172 citations

Receptor-mediated activation of electropermeabilized neutrophils. Evidence for a Ca2+- and protein kinase C-independent signaling pathway.

1988 • 153 citations

Phosphatidic acid and not diacylglycerol generated by phospholipase D is functionally linked to the activation of the NADPH oxidase by FMLP in human neutrophils

1990 • 151 citations

Activation of NADPH-dependent superoxide production in plasma membrane extracts of pig neutrophils by phosphatidic acid.

1988 • 138 citations

Purified protein kinase C phosphorylates a 47-kDa protein in control neutrophil cytoplasts but not in neutrophil cytoplasts from patients with the autosomal form of chronic granulomatous disease.

1988 • 127 citations

Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells.

1988 • 121 citations

Structural and catalytic properties of the solubilized superoxide-generating activity of human polymorphonuclear leukocytes. Solubilization, stabilization in solution, and partial characterization

1979 • 111 citations

Assembly and activation of the NADPH:O2 oxidoreductase in human neutrophils after stimulation with phorbol myristate acetate.

1990 • 108 citations

Complement C5a activation of phospholipase D in human neutrophils. A major route to the production of phosphatidates and diglycerides.

1990 • 101 citations

Phospholipase D in homogenates from HL-60 granulocytes: Implications of calcium and G protein control

1989 • 91 citations

Dual mechanisms in priming of the chemoattractant-induced respiratory burst in human granulocytes. A Ca2+-dependent and a Ca2+-independent route.

1989 • 78 citations

The activity of one soluble component of the cell-free NADPH:O2 oxidoreductase of human neutrophils depends on guanosine 5'-O-(3-thio)triphosphate.

1990 • 60 citations

Utility of staurosporine in uncovering differences in the signal transduction pathways for superoxide production in neutrophils

1990 • 54 citations

Staurosporine, a protein kinase inhibitor, up-regulates the stimulation of human neutrophil respiratory burst by N-formyl peptides and platelet activating factor

1990 • 41 citations

1,2-Diacylglycerol accumulation in human neutrophils does not correlate with respiratory burst activation

1989 • 30 citations

Inhibitory effect of di‐isopropyl fluorophosphate on activation of an O⁻₂‐forming enzyme for polymorphonuclear leukocytes with C3b‐zymosan

1981 • 13 citations

Inhibition of chemotactic factor‐induced neutrophil responsiveness by arachidonic acid

1983 • 10 citations

Effect of the Synthetic Inhibitor Tosylamino-Phenylethyl-Chloromethylketone on Chemotactic Peptide Receptor Activation and Superoxide Production in Human Neutrophils

1986 • 8 citations

Actions of the Protease Inhibitor Phenylmethylsulfonyl Fluoride on Neutrophil Granule Enzyme Secretion and Superoxide Production Induced by fMet-Leu-Phe and Phorbol 12-Myristate-13-Acetate

1989 • 4 citations