The role of cytokines in the regulation of Leydig cell P450c17 gene expression

Interleukin-1 and Its Biologically Related Cytokines

1989 • 1,180 citations

Acetoacetylated lipoproteins used to distinguish fibroblasts from macrophages in vitro by fluorescence microscopy.

1981 • 396 citations

Differential regulation of lipopolysaccharide‐induced interleukin 1 and tumor necrosis factor synthesis: effects of endogenous and exogenous glucocorticoids and the role of the pituitary‐adrenal axis

1989 • 328 citations

The Potential Relevance of Cytokines to Ovarian Physiology: The Emerging Role of Resident Ovarian Cells of the White Blood Cell Series

1990 • 322 citations

Dissociation between interleukin-1 beta mRNA and protein synthesis in human peripheral blood mononuclear cells.

1990 • 225 citations

Interleukin-1 Inhibits Leydig Cell Steroidogenesis in Primary Culture*

1988 • 200 citations

Lipopolysaccharide-induced gene expression in murine peritoneal macrophages is selectively suppressed by agents that elevate intracellular cAMP.

1989 • 196 citations

Steroidogenesis in Rat Leydig Cells: Changes in Activity of 5-ane and 5-ene 3β-Hydroxysteroid Dehydrogenases During Sexual Maturation¹

1976 • 145 citations

Testosterone inhibits cAMP-induced de Novo synthesis of Leydig cell cytochrome P-450(17 alpha) by an androgen receptor-mediated mechanism.

1987 • 143 citations

Structure, cytochemistry, endocytic activity, and immunoglobulin (Fc) receptors of rat testicular interstitial‐tissue macrophages

1983 • 143 citations

10 Paracrine control of the testis

1986 • 142 citations

Interleukin-1 stimulates steroidogenesis in cultured rat Leydig cells

1988 • 138 citations

Effects of Interleukin-1 on Hormone Release from Normal Rat Pituitary Cells in Primary Culture

1987 • 118 citations

Differential effects of single and repeated administrations of gonadotropins on luteinizing hormone receptors and testosterone synthesis in two populations of Leydig cells.

1980 • 113 citations

Interleukin-1 Inhibits Cholesterol Side-Chain Cleavage Cytochrome P450 Expression in Primary Cultures of Leydig Cells^*

1991 • 97 citations

The Testicular Effects of Tumor Necrosis Factor

1990 • 92 citations

Tumor necrosis factor and interleukin-1 stimulate testosterone secretion in adult male rat Leydig cells in vitro.

1990 • 91 citations

Testicular Macrophages: Isolation, Characterization and Hormonal Responsiveness

1983 • 84 citations

Tumor Necrosis Factor a Inhibits Gonadotropin Action in Cultured Porcine Leydig Cells: Site(s) of Action*

1991 • 65 citations

Differential effects of recombinant interleukin-1α and β on leydig cell function

1990 • 65 citations

Tumor necrosis factor-α enhances inhibitory effects of interleukin-1β on Leydig cell steroidogenesis

1990 • 56 citations

Inhibitory actions of interleukin-1β on steroidogenesis in primary cultures of neonatal rat testicular cells

1989 • 50 citations

Glucocorticoid and Cyclic Adenosine 3′5′-Monophosphate-Mediated Induction of Cholesterol Side-Chain Cleavage Cytochrome P450 (P450SCc) in MA-10 Tumor Leydig Cells. Increases in mRNA Are Cycloheximide Sensitive*

1990 • 36 citations

Interleukin-1α-induced changes in androgen and cyclic adenosine 3′,5′-monophosphate release in adult rat Leydig cells in culture

1991 • 35 citations