Involvement of chloride channels in hepatic copper metabolism: ClC-4 promotes copper incorporation into ceruloplasmin☆

Loss of the ClC-7 Chloride Channel Leads to Osteopetrosis in Mice and Man

2001 • 968 citations

The Copper Chaperone for Superoxide Dismutase

1997 • 828 citations

A Delicate Balance: Homeostatic Control of Copper Uptake and Distribution

1999 • 715 citations

Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux

1999 • 572 citations

ClC-5 Cl--channel disruption impairs endocytosis in a mouse model for Dent's disease

2000 • 524 citations

Disruption of ClC-3, a Chloride Channel Expressed on Synaptic Vesicles, Leads to a Loss of the Hippocampus

2001 • 501 citations

Characterization of , a Yeast Gene Involved in Copper Metabolism and Assembly of Cytochrome Oxidase

1996 • 483 citations

Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development

2001 • 435 citations

ClC-5, the chloride channel mutated in Dent’s disease, colocalizes with the proton pump in endocytotically active kidney cells

1998 • 420 citations

The copper transporter CTR1 provides an essential function in mammalian embryonic development

2001 • 368 citations

Identification of a new copper metabolism gene by positional cloning in a purebred dog population

2002 • 353 citations

Biochemical Characterization of the Wilson Disease Protein and Functional Expression in the Yeast Saccharomyces cerevisiae

1997 • 324 citations

Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis

1999 • 267 citations

Copper-induced apical trafficking of ATP7B in polarized hepatoma cells provides a mechanism for biliary copper excretion

2000 • 260 citations

Mutational Analysis Demonstrates That ClC-4 and ClC-5 Directly Mediate Plasma Membrane Currents

1999 • 242 citations

Hepatocyte-specific localization and copper-dependent trafficking of the Wilson’s disease protein in the liver

1999 • 190 citations

The yeast CLC chloride channel functions in cation homeostasis

1998 • 172 citations

Hepatic copper metabolism: Insights from genetic disease

2003 • 170 citations

Characterization of the Interaction between the Wilson and Menkes Disease Proteins and the Cytoplasmic Copper Chaperone, HAH1p

1999 • 168 citations

Wilson's Disease

2000 • 161 citations

The Lys1010–Lys1325 Fragment of the Wilson's Disease Protein Binds Nucleotides and Interacts with the N-terminal Domain of This Protein in a Copper-dependent Manner

2001 • 154 citations

Mechanisms of Copper Incorporation into Human Ceruloplasmin

2002 • 152 citations

Biophysical Properties of ClC-3 Differentiate It from Swelling-activated Chloride Channels in Chinese Hamster Ovary-K1 Cells

2000 • 134 citations

The ClC-3 chloride channel promotes acidification of lysosomes in CHO-K1 and Huh-7 cells

2002 • 131 citations

Golgi Localization and Functionally Important Domains in the NH2 and COOH Terminus of the Yeast CLC Putative Chloride Channel Gef1p

1998 • 126 citations

Chloride is an allosteric effector of copper assembly for the yeast multicopper oxidase Fet3p: An unexpected role for intracellular chloride channels

1998 • 119 citations

The Chloride Channel ClC-4 Contributes to Endosomal Acidification and Trafficking

2003 • 105 citations

Localization of the Wilson's disease protein in human liver

1999 • 103 citations

Biochemical Analysis of a Missense Mutation in Aceruloplasminemia

2002 • 84 citations

Intrarenal and subcellular localization of rat CLC5

1998 • 74 citations

Expression and canalicular localization of two isoforms of the ClC-3 chloride channel from rat hepatocytes

2000 • 63 citations

Functional characterization of recombinant human ClC‐4 chloride channels in cultured mammalian cells

2002 • 60 citations

The Chloride Channel ClC-4 Co-localizes with Cystic Fibrosis Transmembrane Conductance Regulator and May Mediate Chloride Flux across the Apical Membrane of Intestinal Epithelia

2002 • 55 citations

Biological and clinicopathological features associated with hepatitis C virus type 5 infections

1996 • 52 citations

Chloride Channels and Hepatocellular Function: Prospects for Molecular Identification

2002 • 50 citations

Immunoisolation and Characterization of a Subdomain of the Endoplasmic Reticulum That Concentrates Proteins Involved in COPII Vesicle Biogenesis

1998 • 49 citations

Metallothionein and copper in liver disease with copper retention—a histopathological study

1989 • 39 citations

Understanding the mechanism and function of copper P-type ATPases

2002 • 39 citations

Indian childhood cirrhosis and Tyrolean childhood cirrhosis. Disorders of a copper transport gene?

1999 • 21 citations