The Chloride Channel ClC-4 Contributes to Endosomal Acidification and Trafficking

X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity

2002 • 1,571 citations

Endocytosis

1997 • 1,263 citations

Molecular Structure and Physiological Function of Chloride Channels

2002 • 1,234 citations

Loss of the ClC-7 Chloride Channel Leads to Osteopetrosis in Mice and Man

2001 • 968 citations

The Skeletal Muscle Chloride Channel in Dominant and Recessive Human Myotonia

1992 • 713 citations

ClC-5 Cl--channel disruption impairs endocytosis in a mouse model for Dent's disease

2000 • 524 citations

Disruption of ClC-3, a Chloride Channel Expressed on Synaptic Vesicles, Leads to a Loss of the Hippocampus

2001 • 501 citations

ClC-5, the chloride channel mutated in Dent’s disease, colocalizes with the proton pump in endocytotically active kidney cells

1998 • 420 citations

Inactivation of muscle chloride channel by transposon insertion in myotonic mice

1991 • 382 citations

Transport from late endosomes to lysosomes, but not sorting of integral membrane proteins in endosomes, depends on the vacuolar proton pump.

1995 • 331 citations

The CLC chloride channel family

1999 • 321 citations

Regulation of Organelle Acidity

2001 • 302 citations

Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis

2000 • 298 citations

Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies

2003 • 293 citations

Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease

1999 • 281 citations

Mutational Analysis Demonstrates That ClC-4 and ClC-5 Directly Mediate Plasma Membrane Currents

1999 • 242 citations

Characterization of Rapid Membrane Internalization and Recycling

2000 • 228 citations

The ClC-5 chloride channel knock-out mouse – an animal model for Dent's disease

2003 • 194 citations

Determinants of the Phagosomal pH in Neutrophils

2002 • 176 citations

Bafilomycin A1 Treatment Retards Transferrin Receptor Recycling More than Bulk Membrane Recycling

1997 • 170 citations

Characterisation of renal chloride channel, CLCN5, mutations in hypercalciuric nephrolithiasis (kidney stones) disorders

1997 • 157 citations

Regulation of Phagosomal Acidification

1997 • 156 citations

An Internalization Signal in ClC-5, an Endosomal Cl−Channel Mutated in Dent's Disease

2001 • 135 citations

Transferrin receptor recycling in the absence of perinuclear recycling endosomes

2002 • 134 citations

The PDZ-binding Chloride Channel ClC-3B Localizes to the Golgi and Associates with Cystic Fibrosis Transmembrane Conductance Regulator-interacting PDZ Proteins

2003 • 134 citations

Export from Pericentriolar Endocytic Recycling Compartment to Cell Surface Depends on Stable, Detyrosinated (Glu) Microtubules and Kinesin

2002 • 133 citations

Biogenesis of the Sorting Endosome: The Role of Rab5

2000 • 132 citations

The ClC-3 chloride channel promotes acidification of lysosomes in CHO-K1 and Huh-7 cells

2002 • 131 citations

Genomic organization of the human muscle chloride channel CIC-1 and analysis of novel mutations leading to Becker-type myotonia

1994 • 130 citations

Projection structure of a ClC-type chloride channel at 6.5 Å resolution

2001 • 123 citations

Internalization and intracellular transport of folate-binding protein in rat kidney proximal tubule

1993 • 118 citations

The role of ClC‐3 in volume‐activated chloride currents and volume regulation in bovine epithelial cells demonstrated by antisense inhibition

2000 • 117 citations

Chloride channels of intracellular organelles

1995 • 112 citations

Thyrotropin induces the acidification of the secretory granules of parafollicular cells by increasing the chloride conductance of the granular membrane.

1988 • 94 citations

Physiological importance of endosomal acidification: potential role in proximal tubulopathies

2002 • 94 citations

Dynamics of rab5 activation in endocytosis and phagocytosis

2000 • 93 citations

From Tonus to Tonicity

2000 • 80 citations

Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice

1995 • 73 citations

ClC-2 Contributes to Native Chloride Secretion by a Human Intestinal Cell Line, Caco-2

2001 • 73 citations

Sequential Actions of Rab5 and Rab7 Regulate Endocytosis in the Xenopus Oocyte

1997 • 66 citations

The Chloride Channel ClC-4 Co-localizes with Cystic Fibrosis Transmembrane Conductance Regulator and May Mediate Chloride Flux across the Apical Membrane of Intestinal Epithelia

2002 • 55 citations

Structure and properties of the clathrin-coated vesicle and yeast vacuolar V-ATPases.

1999 • 42 citations

Molecular Cloning and Characterization of an Intracellular Chloride Channel in the Proximal Tubule Cell Line, LLC-PK1

2000 • 35 citations

Expression of Chloride Channel, ClC-5, and Its Role in Receptor-Mediated Endocytosis of Albumin in OK Cells

2001 • 23 citations

Amelioration of Intestinal Disease Severity in Cystic Fibrosis Mice Is Associated with Improved Chloride Secretory Capacity

2000 • 17 citations

Role of ClC-5 in the pathogenesis of hypercalciuria: recent insights from transgenic mouse models

2001 • 15 citations