Activation of bleomycin A2 to a DNA-damaging intermediate by phorbol ester-stimulated human polymorphonuclear leukocytes

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1982 • 1,559 citations

Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA.

1981 • 458 citations

Effect of chelating agents and metal ions on the degradation of DNA by bleomycin

1978 • 367 citations

Stimulated Human Phagocytes Produce Cytogenetic Changes in Cultured Mammalian Cells

1983 • 262 citations

DNA Strand Breakage in Human Leukocytes Exposed to a Tumor Promoter, Phorbol Myristate Acetate

1982 • 255 citations

The mechanism of the bleomycin-induced cleavage of DNA

1977 • 247 citations

Activation of pharmacologic agents to radical intermediates

1982 • 190 citations

Increased DNA chain breakage by combined action of bleomycin and superoxide radical

1975 • 183 citations

Mechanism of bleomycin action: studies

1981 • 145 citations

Modifiers of free radicals inhibit in vitro the oncogenic actions of x-rays, bleomycin, and the tumor promoter 12-O-tetradecanoylphorbol 13-acetate.

1983 • 126 citations

Effects of oxygen radical scavengers and antioxidants on phagocyte-induced mutagenesis.

1982 • 121 citations

Chemical carcinogenesis: a biologic perspective.

1982 • 99 citations

Inhibiton of phorbol ester-stimulated chemiluminescence in human polymorphonuclear leukocytes by retinoic acid and 5,6-epoxyretinoic acid.

1981 • 83 citations

Estrogen binding by leukocytes during phagocytosis,.

1977 • 68 citations

Do Tumor Promoters Affect DNA After All?

1983 • 53 citations

Studies on the interaction of bleomycin A2 with rat lung microsomes. II. Involvement of adventitious iron and reactive oxygen in bleomycin-mediated DNA chain breakage.

1982 • 47 citations

Redox cycling of Fe(III)-bleomycin by NADPH-cytochrome P-450 reductase

1981 • 45 citations

Studies on the interaction of bleomycin A2 with rat lung microsomes. I. Characterization of factors which influence bleomycin-mediated DNA chain breakage.

1982 • 26 citations

Free-Radical Production by Reticuloendothelial Cells

1980 • 26 citations

Specificity of chemiluminescence in the metabolism of benzo[a]pyrene to its carcinogenic diol epoxide.

1981 • 15 citations

Comparison of the interaction of tricyclic antidepressants with human polymorphonuclear leukocytes as monitored by the generation of chemiluminescence

1979 • 13 citations

Non-enzymatic extramicrosomal bioactivation of chemical carcinogens by phagocytes: A proposed new pathway

1982 • 10 citations

Studies on the interaction of bleomycin A2 with rat lung microsomes. III. Effect of exogenous iron on bleomycin-mediated DNA chain breakage

1983 • 10 citations

Correlation between level of defense against active oxygen in Escherichia coli K12 and resistance to Bleomycin.

1982 • 5 citations