Peroxynitrite-dependent activation of src tyrosine kinases lyn and hck in erythrocytes is under mechanistically different pathways of redox control

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

1997 • 2,470 citations

Protein modules and signalling networks

1995 • 2,447 citations

Redox signaling: Nitrosylation and related target interactions of nitric oxide

1994 • 1,732 citations

Extensive Nitration of Protein Tyrosines in Human Atherosclerosis Detected by Immunohistochemistry

1994 • 1,138 citations

Specific and Reversible Inactivation of Protein Tyrosine Phosphatases by Hydrogen Peroxide: Evidence for a Sulfenic Acid Intermediate and Implications for Redox Regulation

1998 • 933 citations

An essential role for free radicals and derived species in signal transduction

1997 • 909 citations

Peroxynitrite‐mediated oxidative protein modifications

1995 • 611 citations

Peroxynitrite-Mediated Inactivation of Manganese Superoxide Dismutase Involves Nitration and Oxidation of Critical Tyrosine Residues

1998 • 506 citations

A Molecular Redox Switch on p21

1997 • 488 citations

Diffusion of peroxynitrite across erythrocyte membranes

1998 • 399 citations

Peroxynitrite-Dependent Tryptophan Nitration

1996 • 254 citations

Redox modulation of tyrosine phosphorylation-dependent signal transduction pathways

1996 • 242 citations

Irreversible inhibition of v-src tyrosine kinase activity by herbimycin a and its abrogation by sulfhydryl compounds

1989 • 217 citations

Regulation of c-Src tyrosine kinase activity by the Src SH2 domain.

1993 • 208 citations

Rapid and Irreversible Inactivation of Protein Tyrosine Phosphatases PTP1B, CD45, and LAR by Peroxynitrite

1999 • 197 citations

Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394.

1995 • 179 citations

Carbon Dioxide: Physiological Catalyst for Peroxynitrite-Mediated Cellular Damage or Cellular Protectant?

1996 • 176 citations

Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation.

1988 • 176 citations

Peroxynitrite modulates tyrosine‐dependent signal transduction pathway of human erythrocyte band 3

1997 • 168 citations

Nitric Oxide Controls Src Kinase Activity through a Sulfhydryl Group Modification-mediated Tyr-527-independent and Tyr-416-linked Mechanism

1999 • 165 citations

Peroxynitrite-mediated modification of proteins at physiological carbon dioxide concentration: pH dependence of carbonyl formation, tyrosine nitration, and methionine oxidation

1999 • 159 citations

Evidence for peroxynitrite as a signaling molecule in flow-dependent activation of c-Jun NH₂-terminal kinase

1999 • 155 citations

Formation of S-Nitrosothiols via Direct Nucleophilic Nitrosation of Thiols by Peroxynitrite with Elimination of Hydrogen Peroxide

1998 • 154 citations

Activation pattern of mitogen‐activated protein kinases elicited by peroxynitrite: attenuation by selenite supplementation

1999 • 126 citations

Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts

2000 • 120 citations

Tyrosine Nitration of c-SRC Tyrosine Kinase in Human Pancreatic Ductal Adenocarcinoma

2000 • 118 citations

Peroxynitrite Inactivation of Tyrosine Hydroxylase: Mediation by Sulfhydryl Oxidation, not Tyrosine Nitration

1999 • 117 citations

Peroxynitrite modulates tyrosine phosphorylation and phosphoinositide signalling in human neuroblastoma SH-SY5Y cells: attenuated effects in human 1321N1 astrocytoma cells

1998 • 115 citations

Diffusion of Peroxynitrite in the Presence of Carbon Dioxide

1999 • 110 citations

Peroxynitrite Induces Tyrosine Nitration and Modulates Tyrosine Phosphorylation of Synaptic Proteins

1999 • 102 citations

[37] Peroxynitrite reactions with carbon dioxide-bicarbonate

1999 • 101 citations

Peroxynitrite Induces Covalent Dimerization of Epidermal Growth Factor Receptors in A431 Epidermoid Carcinoma Cells

1998 • 100 citations

Regulation of Src Family Tyrosine Kinase Activities in Adherent Human Neutrophils

1996 • 93 citations

Phosphorylation of c-Src on Tyrosine 527 by Another Protein Tyrosine Kinase

1991 • 92 citations

Peroxynitrite Modulates the Activation of p38 and Extracellular Regulated Kinases in PC12 Cells

2000 • 78 citations

Activation of src tyrosine kinases by peroxynitrite

1999 • 71 citations

Evidence of a novel redox-linked activation mechanism for the Src kinase which is independent of tyrosine 527-mediated regulation.

1996 • 69 citations

Conserved cysteine residues are critical for the enzymatic function of the lymphocyte-specific tyrosine protein kinase p56lck

1993 • 50 citations

Clustered cysteine residues in the kinase domain of v-Src: critical role for protein stability, cell transformation and sensitivity to herbimycin A

2000 • 48 citations

Phosphorylation of a Src Kinase at the Autophosphorylation Site in the Absence of Src Kinase Activity

2000 • 39 citations

Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts

2000 • 36 citations

A Novel Superoxide Dismutase-Based Trap for Peroxynitrite Used To Detect Entry of Peroxynitrite into Erythrocyte Ghosts

1999 • 25 citations