Could the airway epithelium play an important role in mucosal immunoglobulin A production?

Interleukin-6: An Overview

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Cytokine signal transduction

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Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

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Dendritic Cells Interact Directly with Naive B Lymphocytes to Transfer Antigen and Initiate Class Switching in a Primary T-Dependent Response

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Interleukins and IgA synthesis. Human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells.

1989 • 444 citations

INTERACTION OF ANTIGENS AND ANTIBODIES AT MUCOSAL SURFACES

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Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production.

1989 • 394 citations

Expression and generation of interleukin-8, IL-6 and granulocyte-macrophage colony-stimulating factor by bronchial epithelial cells and enhancement by IL-1 beta and tumour necrosis factor-alpha.

1992 • 355 citations

Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis.

1995 • 354 citations

Molecules in focus Transforming growth factor-beta (TGF-β)

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Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production.

1991 • 303 citations

Cytokine production by epithelial cells ¹

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CD5 B Cells, a Fetal B Cell Lineage

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Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells.

1988 • 242 citations

Human Dendritic Cells Skew Isotype Switching of CD40-activated Naive B Cells towards IgA1 and IgA2

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Is the Bronchus-associated Lymphoid Tissue (BALT) an Integral Structure of the Lung in Normal Mammals, Including Humans?

1990 • 240 citations

Transforming growth factor-beta directs IgA switching in human B cells.

1992 • 232 citations

Defective B-1 Cell Development and Impaired Immunity against Angiostrongylus cantonensis in IL-5Rα-Deficient Mice

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Continuous anti-interleukin 10 antibody administration depletes mice of Ly-1 B cells but not conventional B cells.

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Recombinant human interleukin 5 is an eosinophil differentiation factor but has no activity in standard human B cell growth factor assays

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Alveolar type II epithelial cells produce interleukin-6 in vitro and in vivo. Regulation by alveolar macrophage secretory products.

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The human gut contains a novel population of B lymphocytes which resemble marginal zone cells.

1985 • 168 citations

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CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-beta: evidence for TGF-beta but not IL-10-dependent direct S mu-->S alpha and sequential S mu-->S gamma, S gamma-->S alpha DNA recombination.

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In Situ Expression of Interleukin-10 in Noninflamed Human Gut and in Inflammatory Bowel Disease

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Immunity to Rotavirus in T Cell Deficient Mice

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Is BALT a major component of the human lung immune system?

1992 • 145 citations

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1993 • 145 citations

Interleukin 10 induces B lymphocytes from IgA-deficient patients to secrete IgA.

1994 • 136 citations

CD40 Engagement Triggers Switching to IgA1 and IgA2 in Human B Cells Through Induction of Endogenous TGF-β: Evidence for TGF-β But Not IL-10-Dependent Direct Sμ→Sα and Sequential Sμ→Sγ, Sγ→Sα DNA Recombination

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IL-6 is a potent cofactor of IL-1 in IgM synthesis and of IL-5 in IgA synthesis.

1989 • 123 citations

Evidence for Accessory Cell Function by Class II MHC Antigen-expressing Airway Epithelial Cells

1991 • 117 citations

Lymphoid Aggregates in Endobronchial Biopsies from Young Elite Cross-country Skiers

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Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene.

1991 • 103 citations

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Diverse cellular TGF-beta 1 and TGF-beta 3 gene expression in normal human and murine lung

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The Distribution of MHC Class I and II Antigens on Bronchial Epithelium

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Human Ciliated Bronchial Epithelial Cells: Expression of the HLA-DR Antigens and of the HLA-DR Alpha Gene, Modulation of the HLA-DR Antigens by Gamma-Interferon and Antigen-presenting Function in the Mixed Leukocyte Reaction

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Transforming growth factor beta in normal human lung: preferential location in bronchial epithelial cells.

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Plasma Cells and Epithelial Immunoglobulins in the Mouse Mammary Gland during Pregnancy and Lactation

1977 • 84 citations

Intestinal IgA plasma cells of the B1 lineage are IL‐5 dependent

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Spontaneous production of transforming growth factor-beta 2 by primary cultures of bronchial epithelial cells. Effects on cell behavior in vitro.

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Immunocytochemical Colocalization of Specific Immunoglobulin A with Sendai Virus Protein in Infected Polarized Epithelium

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Differential regulation of IgA production by TGF-β and IL-5: TGF-β induces surface IgA-positive cells bearing IL-5 receptor, whereas IL-5 promotes their survival and maturation into IgA-secreting cells

1992 • 74 citations

Interleukin 5 is a differentiation factor for IgA B cells

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Synthesis and regulation of accessory/proinflammatory cytokines by intestinal epithelial cells

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Structure of TGF-β1-induced human immunoglobulin Cα1 and Cα2 germ-line transcripts

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IgA, IgG and IgM quantification in bronchoalveolar lavage fluids from allergic rhinitics, allergic asthmatics, and normal subjects by monoclonal antibody-based immunoenzymetric assays

1995 • 60 citations

The effect of recombinant human interleukin-5 on eosinophil accumulation and degranulation in human nasal mucosa

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Cholera Toxin and Cholera Toxin B Subunit Induce IgA Switching Through the Action of TGF-β1

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Ultrastructural evidence of transport of secretory IgA across bronchial epithelium.

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Interleukin‐5 expressed by a recombinant virus vector enhances specific mucosal IgA responses in vivo

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The role of interleukin-5 (IL-5 ) in vivo: studies with IL-5 deficient mice

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Immunohistochemical characterization of intraepithelial and subepithelial mononuclear cells of the upper airways.

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Distribution of plasma cells and other cells containing immunoglobulin in the respiratory tract of normal man and class of immunoglobulin contained therein.

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HLA antigens in selective IgA deficiency: Distribution in healthy donors and patients with recurrent respiratory tract infections

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Dendritic cells support production of IgA and other non-IgM isotypes in clonal microculture

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Ig isotype switching in B lymphocytes. The effect of T cell-derived interleukins, cytokines, cholera toxin, and antigen on isotype switch frequency of a cloned B cell lymphoma

1991 • 46 citations

Transforming growth factor-β1 (TGF-β1) is a bifunctional immune regulator for mucosal IgA responses

1990 • 42 citations

Requirements for B7-CD28 costimulation in mucosal IgA responses: paradoxes observed in CTLA4-H gamma 1 transgenic mice.

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Synergistic augmentative effect of interleukin‐10 and CD27/CD70 interactions on B‐cell immunoglobulin synthesis

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Mucosal immunity--a major adaptive defence mechanism.

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Modification of cytokine patterns in subjects bearing the HLA-B8,DR3 phenotype: implications for autoimmunity.

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Increased mRNA encoding for transforming factor-β in CD4+ cells from patients with IgA nephropathy

1994 • 40 citations

Elevation of specific immunoglobulin A antibodies to both allergen and bacterial antigen in induced sputum from asthmatics

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New frontiers for IL-5

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IgA production by peritoneal cavity B cells is IL‐6 independent: Implications for intestinal IgA response

1995 • 34 citations

Regulation of IgA B Cell Development

1994 • 33 citations

Requirements for B7-CD28 Costimulation in Mucosal IgA Responses: Paradoxes Observed in CTLA4-Hγ1 Transgenic Mice

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Low incidence of bronchus-associated lymphoid tissue (BALT) in chronically inflamed human lungs

1992 • 33 citations

Induction of MHC class II antigens on rat bronchial epithelial cells by interferon-gamma and its effect on antigen presentation

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CD4‐positive cells from patients with IgA nephropathy demonstrate increased mRNA of cytokines that induce the IgA switch and differentiation

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Reduced Serum Level of Transforming Growth Factor-β in Patients with IgA Deficiency

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Pulmonary immune memory: localized production of antibody in the lung after antigen challenge

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Immunoglobulins and Blood Vessels in the Tonsillar Crypt Epithelium

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Induction of high affinity IL 2 receptors on B cells responding to anti-Ig and T cell-derived helper factors.

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Induction of T Helper Cells and Cytokines for Mucosal IgA Responses

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Cytokine Receptors on Ly‐1 B Cells

1992 • 19 citations

SEMI-QUANTITATIVE POLYMERASE CHAIN REACTION ANALYSIS OF CYTOKINE AND CYTOKINE RECEPTOR GENE EXPRESSION DURING THYMIC ONTOGENY

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Interleukin 5 Regulation of Peritoneal B‐Cell Proliferation and Antibody Secretion

1990 • 16 citations

Cytokine expression and production by tonsillar lymphocytes.

1996 • 12 citations

Hypothesis: Interleukin-5 Production Impairment can be a Key Point in the Pathogenesis of the MHC-Linked Selective IgA Deficiency

1998 • 12 citations

The Influence of Costimulation and Regulatory Cd4+ T Cells on Intestinal Iga Immune Responses

1997 • 9 citations

A transforming growth factor-beta regulable RNA-binding protein interacts specifically with germline Ig alpha transcripts

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The effects of transforming growth factor‐ and interleukins 2,5 and 6 on immunoglobulin production in cultured rat salivary gland tissues

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IgA B Cell Differentiation

1989 • 4 citations

Recombinant vaccinia viruses expressing interleukin‐5 stimulate an earlier appearance of antibody‐secreting cells in the lung

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Production of B cell differentiation factors by mouse parenchymal liver cells

1997 • 2 citations