Cytokine Induction of Inducible Nitric Oxide Synthase in an Oligodendrocyte Cell Line

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Microglia: a sensor for pathological events in the CNS

1996 • 4,309 citations

AU-rich elements: characterization and importance in mRNA degradation

1995 • 1,936 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide.

1993 • 1,127 citations

Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide.

1993 • 1,077 citations

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1997 • 927 citations

Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

1994 • 840 citations

Cytokines in inflammatory brain lesions: helpful and harmful

1996 • 727 citations

Extracellular Signal-Regulated Kinase and p38 Subgroups of Mitogen-Activated Protein Kinases Regulate Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-α Gene Expression in Endotoxin-Stimulated Primary Glial Cultures

1998 • 709 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

1997 • 658 citations

Synthesis of nitric oxide in CNS glial cells

1993 • 627 citations

The search for physiological substrates of MAP and SAP kinases in mammalian cells

1997 • 544 citations

Nitric Oxide‐Mediated Mitochondrial Damage in the Brain: Mechanisms and Implications for Neurodegenerative Diseases

1997 • 525 citations

In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases.

1993 • 484 citations

Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis.

1995 • 464 citations

Macrophages and inflammation in the central nervous system

1993 • 390 citations

Review: cytokines and the pathogenesis of multiple sclerosis

1996 • 331 citations

Blockade of p38 Mitogen-activated Protein Kinase Pathway Inhibits Inducible Nitric-oxide Synthase Expression in Mouse Astrocytes

1997 • 300 citations

Astrocytes in infectious and immune‐mediated diseases of the central nervous system

1993 • 217 citations

Cloning and expression of inducible nitric oxide synthase from rat astrocytes

1994 • 200 citations

Nitric oxide induces necrotic but not apoptotic cell death in oligodendrocytes

1995 • 197 citations

TNF? potentiates IFN?-induced cell death in oligodendrocyte progenitors

1998 • 157 citations

Interleukin-1β-induced Rat Pancreatic Islet Nitric Oxide Synthesis Requires Both the p38 and Extracellular Signal-regulated Kinase 1/2 Mitogen-activated Protein Kinases

1998 • 155 citations

The role of nitric oxide in multiple sclerosis

1997 • 143 citations

Nitric Oxide in Neuronal Degeneration

1996 • 140 citations

Interactions of the nervous and immune systems in development, normal brain homeostasis, and disease ¹

1995 • 121 citations

Macrophages resistant to endogenously generated nitric oxide-mediated apoptosis are hypersensitive to exogenously added nitric oxide donors: Dichotomous apoptotic response independent of caspase 3 and reversal by the mitogen-activated protein kinase kinase (MEK) inhibitor PD 098059

1998 • 97 citations

Multiple sclerosis: TNF revisited, with promise

1995 • 88 citations

Inducible nitric oxide synthase and nitric oxide production by oligodendrocytes

1997 • 86 citations

Activation of C-jun N-terminal kinase/stress-activated protein kinase in primary glial cultures

1996 • 81 citations

Activation of Mitogen‐Activated Protein Kinases in Oligodendrocytes

1996 • 79 citations

The role of eIF4 in cell proliferation.

1996 • 76 citations

Cytokines, signal transduction, and inflammatory demyelination: review and hypothesis.

1998 • 58 citations

Cytokine‐ and Endotoxin‐Induced Nitric Oxide Synthase in Rat Astroglial Cultures: Differential Modulation by Angiotensin II

1997 • 35 citations

Regulation of inducible nitric oxide synthase expression in human glia: implications for inflammatory central nervous system diseases

1997 • 30 citations

Nitric Oxide Synthase Type II mRNA Stability Is Translation‐ and Transcription‐Dependent

1996 • 26 citations

The neuroimmunology of multiple sclerosis

1996 • 24 citations