Contrasting phenotypes of C57BL/6JOlaHsd, 129S2/SvHsd and 129/SvEv mice in two exploration-based tests of anxiety-related behaviour

The use of a plus-maze to measure anxiety in the mouse

1987 • 2,571 citations

Genetics of Mouse Behavior: Interactions with Laboratory Environment

1999 • 1,626 citations

Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

1997 • 1,362 citations

What's Wrong with My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice

2000 • 934 citations

Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?

1996 • 895 citations

Measuring normal and pathological anxiety-like behaviour in mice: a review

2001 • 884 citations

Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice

1997 • 702 citations

Elevated anxiety and antidepressant-like responses in serotonin 5-HT _1A receptor mutant mice

1998 • 690 citations

Thigmotaxis as a test for anxiolytic activity in rats

1988 • 646 citations

Anxiogenic stimuli in the elevated plus-maze

1993 • 626 citations

The use of behavioral test batteries: Effects of training history

2001 • 555 citations

A Proposed Test Battery and Constellations of Specific Behavioral Paradigms to Investigate the Behavioral Phenotypes of Transgenic and Knockout Mice

1997 • 553 citations

Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues

1999 • 552 citations

Differences in fear motivated behaviors among inbred mouse strains

1993 • 450 citations

Locomotor Activity in D2 Dopamine Receptor-Deficient Mice Is Determined by Gene Dosage, Genetic Background, and Developmental Adaptations

1998 • 448 citations

Strain and gender differences in the behavior of mouse lines commonly used in transgenic studies

2001 • 423 citations

Differences in anxiety-related behaviours and in sensitivity to diazepam in inbred and outbred strains of mice

2000 • 407 citations

Defense system psychopharmacology: An ethological approach to the pharmacology of fear and anxiety

1993 • 359 citations

Influence of social isolation, gender, strain, and prior novelty on plus-maze behaviour in mice

1993 • 302 citations

Use of SHIRPA and discriminant analysis to characterise marked differences in the behavioural phenotype of six inbred mouse strains

1999 • 291 citations

Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in mice

2002 • 275 citations

Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice

2001 • 264 citations

Behavioural analysis of four mouse strains in an anxiety test battery

2000 • 261 citations

Influence of prior maze experience on behaviour and response to diazepam in the elevated plus-maze and light/dark tests of anxiety in mice

1993 • 216 citations

Targeted gene mutation approaches to the study of anxiety-like behavior in mice

2001 • 203 citations

Psychogenic, neurogenic, and systemic stressor effects on plasma corticosterone and behavior: Mouse strain-dependent outcomes.

2001 • 197 citations

Genetic inactivation of the Serotonin(1A) receptor in mice results in downregulation of major GABA(A) receptor alpha subunits, reduction of GABA(A) receptor binding, and benzodiazepine-resistant anxiety.

2000 • 184 citations

Unusual behavioral phenotypes of inbred mouse strains

1996 • 184 citations

Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains

1982 • 181 citations

Habituation of activity in an open field: A survey of inbred strains and F1 hybrids.

2000 • 181 citations

Responses of Swiss–Webster Mice to Repeated Plus-Maze Experience Further Evidence for a Qualitative Shift in Emotional State?

1998 • 177 citations

A comparison of 129S2/SvHsd and C57BL/6JOlaHsd mice on a test battery assessing sensorimotor, affective and cognitive behaviours: implications for the study of genetically modified mice

2001 • 169 citations

Standardizing tests of mouse behavior: Reasons, recommendations, and reality

2001 • 164 citations

Pain Genes?: Natural Variation and Transgenic Mutants

2000 • 164 citations

Behavior and mutagenesis screens: the importance of baseline analysis of inbred strains

2000 • 158 citations

Complications associated with genetic background effects in research using knockout mice

1999 • 154 citations

Genetic Inactivation of the Serotonin_1AReceptor in Mice Results in Downregulation of Major GABA_AReceptor α Subunits, Reduction of GABA_AReceptor Binding, and Benzodiazepine-Resistant Anxiety

2000 • 153 citations

Differences in anxiety-related behavior and response to diazepam in BALB/cByJ and C57BL/6J strains of mice

2000 • 149 citations

Link between emotional memory and anxiety states: A study by principal component analysis

1995 • 149 citations

Behavioural performance in three substrains of mouse strain 129

1997 • 144 citations

The inheritance of behavior: behavioural differences in fifteen mouse strains.

1953 • 137 citations

Pharmacologic and Behavioral Responses of Inbred C57BL/6J and Strain 129/SvJ Mouse Lines

1999 • 136 citations

Commentary: The broken mouse: the role of development, plasticity and environment in the interpretation of phenotypic changes in knockout mice

2000 • 121 citations

Prior test experience compromises the anxiolytic efficacy of chlordiazepoxide in the mouse light/dark exploration test

2001 • 105 citations

Differential analysis of behavior and diazepam-induced alterations in C57BL/6N and BALB/c mice using the modified hole board test

2001 • 102 citations

Gene targeting: technical confounds and potential solutions in behavioral brain research

2001 • 101 citations

Behavioral Phenotyping of Transgenic and Knockout Mice

1999 • 99 citations

A behavioral and neuroanatomical assessment of an inbred substrain of 129 mice with behavioral comparisons to C57BL/6J mice

1999 • 92 citations

Behavior in Mice with Targeted Disruption of Single Genes

1998 • 89 citations

The 5-HT 1A receptor knockout mouse and anxiety

2001 • 88 citations

Anxiety-related behaviors in the elevated zero-maze are affected by genetic factors and retinal degeneration.

2001 • 87 citations

Central Nervous System Serotonin and Norepinephrine Localization in Emotional and Non-Emotional Strains in Mice

1964 • 83 citations

The genetic basis of the pharmacological effects of anxiolytics: a review based on rodent models

2001 • 68 citations

Flumazenil induces benzodiazepine partial agonist-like effects in BALB/c but not C57BL/6 mice

2000 • 61 citations

Transgenic and knockout databases

2001 • 60 citations

Regional patterns of compensation following genetic deletion of either 5-hydroxytryptamine(1A) or 5-hydroxytryptamine(1B) receptor in the mouse.

2001 • 59 citations

Influence of 5-HT1A Receptor Antagonism on Plus-Maze Behaviour in Mice. II. WAY 100635, SDZ 216-525 and NAN-190

1997 • 58 citations

Mice Lacking the Long Splice Variant of the γ2 Subunit of the GABAA Receptor Are More Sensitive to Benzodiazepines

2000 • 46 citations

Loss of aggression, after transfer onto a C57BL/6J background, in mice carrying a targeted disruption of the neuronal nitric oxide synthase gene.

2000 • 45 citations

Genetic influences on latent inhibition.

1999 • 39 citations

Chipping away at complex behavior: Transcriptome/phenotype correlations in the mouse brain

2001 • 33 citations

Blockade of anxiolytic-like actions of chlordiazepoxide by naloxone in the elevated plus-maze: Comparisons between Swiss, C57BL/6, and BALB/c mice

1999 • 18 citations