Transgenic and knockout databases

Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

2000 • 1,628 citations

Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

1994 • 1,485 citations

Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

1996 • 1,467 citations

Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,458 citations

Targeted disruption of the neuronal nitric oxide synthase gene

1993 • 1,300 citations

Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

1995 • 1,264 citations

Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice

1992 • 1,138 citations

Mice lacking brain-derived neurotrophic factor develop with sensory deficits

1994 • 1,066 citations

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

1994 • 1,065 citations

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice.

1996 • 1,020 citations

Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons

1993 • 1,019 citations

Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning

1994 • 1,010 citations

Fmr1 knockout mice: A model to study fragile X mental retardation

1994 • 1,007 citations

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

1994 • 1,000 citations

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene

1994 • 978 citations

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

1992 • 960 citations

Skeletal and CNS Defects in Presenilin-1-Deficient Mice

1997 • 953 citations

Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons

1994 • 934 citations

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death.

1996 • 901 citations

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.

1992 • 897 citations

Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents

1994 • 804 citations

Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests1Published on the World Wide Web on 2 December 1998.1

1999 • 751 citations

Inactivation of the Mouse Huntington's Disease Gene Homolog Hdh

1995 • 705 citations

Essential functions of synapsins I and II in synaptic vesicle regulation

1995 • 699 citations

Neuronal position in the developing brain is regulated by mouse disabled-1

1997 • 698 citations

Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death

1993 • 670 citations

Pleiotropic effects of a null mutation in the c-fos proto-oncogene

1992 • 643 citations

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues.

1994 • 634 citations

Mice Lacking Metabotropic Glutamate Receptor 5 Show Impaired Learning and Reduced CA1 Long-Term Potentiation (LTP) But Normal CA3 LTP

1997 • 631 citations

Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements

1994 • 620 citations

Transcription factor AP-2 essential for cranial closure and craniofacial development

1996 • 611 citations

Different phenotypes for mice deficient in either activins or activin receptor type II

1995 • 598 citations

twist is required in head mesenchyme for cranial neural tube morphogenesis.

1995 • 595 citations

Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death

1995 • 583 citations

Deletion of the KV1.1 Potassium Channel Causes Epilepsy in Mice

1998 • 579 citations

Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux

1999 • 572 citations

Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need

1995 • 525 citations

Attenuated sensitivity to neuroactive steroids in γ-aminobutyrate type A receptor delta subunit knockout mice

1999 • 522 citations

Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum

1994 • 509 citations

Modified hippocampal long-term potentiation in PKCγ-mutant mice

1993 • 507 citations

Enhanced LTP in Mice Deficient in the AMPA Receptor GluR2

1996 • 494 citations

Mice Deficient in the α7 Neuronal Nicotinic Acetylcholine Receptor Lack α-Bungarotoxin Binding Sites and Hippocampal Fast Nicotinic Currents

1997 • 493 citations

Central Hypotensive Effects of the α _2a -Adrenergic Receptor Subtype

1996 • 484 citations

The role of Rab3A in neurotransmitter release

1994 • 481 citations

Mice devoid of γ-aminobutyrate type A receptor β3 subunit have epilepsy, cleft palate, and hypersensitive behavior

1997 • 478 citations

A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice.

1996 • 473 citations

Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice

1998 • 472 citations

Assembly of CNS Myelin in the Absence of Proteolipid Protein

1997 • 454 citations

Mouse models of Tay–Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism

1995 • 438 citations

Pituitary Lactotroph Hyperplasia and Chronic Hyperprolactinemia in Dopamine D2 Receptor-Deficient Mice

1997 • 423 citations

Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1

1998 • 398 citations

Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin D28k gene

1997 • 397 citations

Inner Ear Defects Induced by Null Mutationof the isk Gene

1996 • 395 citations

Sensory but not motor neuron deficits in mice lacking NT4 and BDNF

1995 • 381 citations

Ectopically Expressed CAG Repeats Cause Intranuclear Inclusions and a Progressive Late Onset Neurological Phenotype in the Mouse

1997 • 374 citations

Collagen COL4A3 knockout: a mouse model for autosomal Alport syndrome.

1996 • 374 citations

Myelination in the absence of myelin-associated glycoprotein

1994 • 365 citations

A mouse model for the learning and memory deficits associated with neurofibromatosis type I

1997 • 352 citations

Altered striatal function in a mutant mouse lacking D1A dopamine receptors.

1994 • 350 citations

Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology.

1996 • 347 citations

A Defect in Nurturing in Mice Lacking the Immediate Early Gene fosB

1996 • 340 citations

Short-term synaptic plasticity is altered in mice lacking synapsin I

1993 • 332 citations

Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis.

1996 • 323 citations

Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase

1997 • 320 citations

Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants

1994 • 310 citations

Progressive ataxia, myoclonic epilepsy and cerebellar apoptosis in cystatin B-deficient mice

1998 • 300 citations

Ovarian Function in Superoxide Dismutase 1 and 2 Knockout Mice

1998 • 279 citations

Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice

1996 • 268 citations

Forward and Reverse Genetic Approaches to Behavior in the Mouse

1994 • 243 citations

Targeted disruption of the mouse sphingolipid activator protein gene: a complex phenotype, including severe leukodystrophy and wide-spread storage of multiple sphingolipids

1996 • 216 citations

Tissue non-specific alkaline phosphatase is expressed in both embryonic and extraembryonic lineages during mouse embryogenesis but is not required for migration of primordial germ cells

1995 • 212 citations

Targeted inactivation of the X-linked adrenoleukodystrophy gene in mice

1997 • 206 citations

Impaired Cerebellar Synaptic Plasticity and Motor Performance in Mice Lacking the mGluR4 Subtype of Metabotropic Glutamate Receptor

1996 • 204 citations

Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease.

1994 • 192 citations

Using Knockout and Transgenic Mice to Study Neurophysiology and Behavior

1998 • 187 citations

Gene Knockout of the α6 Subunit of the γ-Aminobutyric Acid Type A Receptor: Lack of Effect on Responses to Ethanol, Pentobarbital, and General Anesthetics

1997 • 180 citations

Sp4, a Member of the Sp1-Family of Zinc Finger Transcription Factors, Is Required for Normal Murine Growth, Viability, and Male Fertility

1996 • 170 citations

Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death

1993 • 164 citations

The Evil proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development

1997 • 164 citations

Null Mutation of c-fosImpairs Structural and Functional Plasticities in the Kindling Model of Epilepsy

1996 • 135 citations

Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice.

1993 • 123 citations

Handbook of Molecular-Genetic Techniques for Brain and Behavior Research

1999 • 118 citations

Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homolog.

1995 • 116 citations

Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the γ2 subunit of the γ-aminobutyrate type A receptor

1999 • 106 citations

Mutation of theEmx-1Homeobox Gene Disrupts the Corpus Callosum

1996 • 103 citations

Mouse model of G _M2 activator deficiency manifests cerebellar pathology and motor impairment

1997 • 101 citations

Loss of bombesin-induced feeding suppression in gastrin-releasing peptide receptor-deficient mice

1998 • 93 citations

Behavior in Mice with Targeted Disruption of Single Genes

1998 • 89 citations

The Use of Genetic “Knockout” Mice in Behavioral Endocrinology Research

1997 • 86 citations

Developing mouse models of aging: a consideration of strain differences in age-related behavioral and neural parameters☆

1999 • 77 citations

List of transgenic and knockout mice: behavioral profiles

2000 • 73 citations

Behavioral assessment of c-fos mutant mice

1994 • 70 citations

Transgenic animals: Generation and use

1997 • 67 citations

Ovarian Function in Superoxide Dismutase 1 and 2 Knockout Mice

1998 • 63 citations

Transgenic animals in integrative biology: approaches and interpretations of outcome

2000 • 55 citations

Altered spatial learning and memory in mice lacking the mGluR4 subtype of metabotropic glutamate receptor.

1998 • 54 citations

Altered spatial learning and memory in mice lacking the mGluR4 subtype of metabotropic glutamate receptor.

1998 • 52 citations

A mouse model for the human lysosomal disease aspartylglycosaminuria

1996 • 47 citations

Altered long-term potentiation in the hippocampus of apolipoprotein E-deficient mice

1998 • 44 citations

Transgenic mice in drug dependence research

1998 • 41 citations

Synaptotagmin and synaptic transmission alterations in apolipoprotein E-deficient mice

1999 • 31 citations

Internet resources for transgenic or targeted mutation research

1996 • 31 citations

TBASE: a computerized database for transgenic animals and targeted mutations

1993 • 22 citations

An evaluation of what the mouse knockout experiments are telling us about mammalian behaviour

1997 • 19 citations

To Save or Not to Save: The Role of Repositories in a Period of Rapidly Expanding Development of Genetically Engineered Strains of Mice

2022 • 19 citations

The Jackson Laboratory Induced Mutant Resource.

1994 • 14 citations

Delivering the knockout punch

1996 • 3 citations