Overcoming TNF-αand Drug Resistance of Human Renal Cell Carcinoma Cells by Treatment with Pentoxifylline in Combination with TNF-αor Drugs: The Role of TNF-αmRNA Downregulation in Tumor Cell Sensitization

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Tumor Necrosis Factor (TNF)

1985 • 1,932 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

1986 • 1,305 citations

Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway.

1990 • 509 citations

Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor

1985 • 464 citations

Human tumor necrosis factor produced by human B-cell lines: synergistic cytotoxic interaction with human interferon.

1983 • 458 citations

Independent regulation of tumor necrosis factor and lymphotoxin production by human peripheral blood lymphocytes.

1987 • 372 citations

Mechanism by which caffeine potentiates lethality of nitrogen mustard.

1982 • 294 citations

Multiple mechanisms of resistance to cis-diamminedichloroplatinum(II) in murine leukemia L1210 cells.

1987 • 232 citations

Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.

1987 • 225 citations

A phase I trial of intravenously-administered recombinant tumor necrosis factor-alpha in cancer patients.

1988 • 220 citations

Effect of Pentoxifylline on the Phagocytic Activity, cAMP Levels, and Superoxide Anion Production by Monocytes and Polymorphonuclear Cells

1986 • 214 citations

Tumour cell killing by tumour necrosis factor: inhibition by anaerobic conditions, free-radical scavengers and inhibitors of arachidonate metabolism.

1987 • 206 citations

Lipopolysaccharide-induced gene expression in murine peritoneal macrophages is selectively suppressed by agents that elevate intracellular cAMP.

1989 • 196 citations

Metallothionein-mediated cisplatin resistance in human ovarian carcinoma cells

1987 • 175 citations

Cytostatic and cytotoxic activity of tumor necrosis factor on human cancer cells.

1987 • 152 citations

Induction of tumor necrosis factor expression and resistance in a human breast tumor cell line.

1987 • 137 citations

Pentoxifylline: A New Drug for the Treatment of Intermittent Claudication; Mechanism of Action, Pharmacokinetics, Clinical Efficacy and Adverse Effects

1984 • 134 citations

Cell killing and induction of manganous superoxide dismutase by tumor necrosis factor-(α is mediated by lipoxygenase metabolites of arachidonic acid

1992 • 132 citations

Nonhematopoietic cells selected for resistance to tumor necrosis factor produce tumor necrosis factor.

1986 • 108 citations

Cytotoxic, cell cycle, and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents.

1986 • 107 citations

Kinetics of intravenous and oral pentoxifylline in healthy subjects

1985 • 104 citations

Tumor necrosis factor expression in human epithelial tumor cell lines.

1988 • 102 citations

Differential uptake of cis-diamminedichloroplatinum (II) by sensitive and resistant murine L1210 leukemia cells.

1987 • 102 citations

Pharmacokinetics of Orally Administered Pentoxifylline in Humans

1986 • 99 citations

Target cell DNA fragmentation is mediated by lymphotoxin and tumor necrosis factor.

1987 • 94 citations

Tumor necrosis factor and lymphotoxin gene expression in human tumor cell lines.

1988 • 83 citations

Antitumor effect of tumor necrosis factor against various primarily cultured human cancer cells.

1985 • 77 citations

Pentoxifylline -- a biomedical profile.

1979 • 75 citations

The role of DNA repair in the recovery of human cells from cisplatin toxicity

1981 • 74 citations

Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells☆

1987 • 73 citations

Phase II clinical trial of high-dose recombinant human tumor necrosis factor

1989 • 61 citations

Expression of an exogenous tumor necrosis factor (TNF) gene in TNF-sensitive cell lines confers resistance to TNF-mediated cell lysis.

1992 • 48 citations

Endogenous tumor necrosis factor exerts its protective function intracellularly against the cytotoxicity of exogenous tumor necrosis factor.

1992 • 47 citations

Effects of cis-dichlorodiammine platinum (II) on DNA synthesis in kidney and other tissues of normal and tumour-bearing rats

1976 • 47 citations

Sensitivity of resistant human tumor cell lines to tumor necrosis factor and adriamycin used in combination: correlation between down-regulation of tumor necrosis factor-messenger RNA induction and overcoming resistance.

1992 • 47 citations

Pentoxifylline Treatment in Patients with Occlusive Peripheral Arterial Disease. Circulatory Changes and Effects on Prostaglandin Synthesis

1985 • 40 citations

Haemorheology and cerebrovascular disease: multifunctional approach with pentoxifylline

1981 • 37 citations

Overcoming cis-diamminedichloroplatinum (II) resistance of human ovarian tumor cells by combination treatment with cis-diamminedichloroplatinum (II) and tumor necrosis factor–alpha

1993 • 36 citations

Renal cell carcinoma: basic biology and current approaches to therapy.

1991 • 32 citations

Possible mechanism for differences in sensitivity to cis-platinum in human prostate tumor cell lines

1986 • 31 citations

Stimulatory effect of platinum (iv) ion on the production of superoxide radical from xanthine oxidase and macrophages

1977 • 25 citations

Overcoming tumor necrosis factor-α resistance of human renal and ovarian carcinoma cells by combination treatment with buthionine sulfoximine and tumor necrosis factor-α. Role of tumor necrosis factor-α mRNA down-regulation in tumor cell sensitization

1994 • 23 citations

Southwestern Internal Medicine Conference: Renal Cell Carcinoma

1991 • 16 citations

Microrheological effects of the vasoactive compound 3,7-dimethyl-1-(5-oxo-hexyl)-xanthine (pentoxifylline, BL 191).

1977 • 13 citations

OVERCOMING TNF-ALPHA AND CDDP RESISTANCE OF A HUMAN OVARIAN-CANCER CELL-LINE (C30) BY TREATMENT WITH BUTHIONINE SULFOXIMINE IN COMBINATION WITH TNF-ALPHA AND OR CDDP

1993 • 12 citations