Keratinocytes Produce and Are Regulated by Transforming Growth Factors

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Growth Factors and Cancer

1991 • 2,044 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Autocrine Secretion and Malignant Transformation of Cells

1980 • 1,370 citations

Some recent advances in the chemistry and biology of transforming growth factor-beta.

1987 • 1,308 citations

Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium.

1988 • 962 citations

Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-β

1987 • 938 citations

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

1987 • 895 citations

Human transforming growth factor-α: Precursor structure and expression in E. coli

1984 • 888 citations

Production and auto-induction of transforming growth factor-α in human keratinocytes

1987 • 870 citations

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

1986 • 856 citations

Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta.

1987 • 791 citations

Role of transforming growth factor-beta in the development of the mouse embryo.

1987 • 760 citations

Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor

1987 • 703 citations

Rat Transforming Growth Factor Type 1: Structure and Relation to Epidermal Growth Factor

1984 • 666 citations

Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone.

1987 • 619 citations

Reversible inhibition of normal human prokeratinocyte proliferation by type beta transforming growth factor-growth inhibitor in serum-free medium.

1986 • 559 citations

Distribution and modulation of the cellular receptor for transforming growth factor-beta.

1987 • 556 citations

Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity.

1986 • 541 citations

Human epidermal growth factor: isolation and chemical and biological properties.

1975 • 499 citations

Cell adhesion protein receptors as targets for transforming growth factor-$beta; action

1987 • 498 citations

Transforming growth factor beta increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability.

1988 • 420 citations

Integrated control of growth and differentiation of normal human prokeratinocytes cultured in serum‐free medium: Clonal analyses, growth kinetics, and cell cycle studies

1984 • 414 citations

Reversible Inhibition of Mammary Gland Growth by Transforming Growth Factor-β

1987 • 408 citations

Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family.

1987 • 387 citations

Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria.

1985 • 382 citations

Epithelial Wound Healing Enhanced by Transforming Growth Factor-α and Vaccinia Growth Factor

1987 • 368 citations

Expression in rat fibroblasts of a human transforming growth factor-α cDNA results in transformation

1986 • 346 citations

Cartilage-inducing factor-B is a unique protein structurally and functionally related to transforming growth factor-beta.

1987 • 336 citations

Normal embryo fibroblasts release transforming growth factors in a latent form

1984 • 336 citations

Comparison of Epidermal Growth Factor Binding and Receptor Distribution in Normal Human Epidermis and Epidermal Appendages

1984 • 316 citations

Altered [125I] Epidermal Growth Factor Binding and Receptor Distribution in Psoriasis

1986 • 289 citations

Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermis

1988 • 275 citations

Chemical Carcinogenesis: From Animal Models To Molecular Models In One Decade

1988 • 270 citations

Different transforming growth factor-α species are derived from a glycosylated and palmitoylated transmembrane precursor

1987 • 264 citations

Transforming growth factor‐α: Structure and biological activities

1986 • 250 citations

Vaccinia virus encodes a polypeptide homologous to epidermal growth factor and transforming growth factor

1985 • 249 citations

Regulation of mRNAs for type-1 plasminogen activator inhibitor, fibronectin, and type I procollagen by transforming growth factor-beta. Divergent responses in lung fibroblasts and carcinoma cells.

1988 • 244 citations

Growth modulation of mouse keratinocytes by transforming growth factors.

1988 • 242 citations

Production of transforming growth factor alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle.

1987 • 230 citations

Transforming growth factor alpha and beta expression in human colon cancer lines: implications for an autocrine model.

1987 • 222 citations

Specific binding to cultured cells of 125I-labeled type beta transforming growth factor from human platelets.

1984 • 212 citations

Human transforming growth factor type .beta.2: production by a prostatic adenocarcinoma cell line, purification, and initial characterization

1987 • 204 citations

Growth factors produced by sarcoma virus-transformed cells.

1978 • 191 citations

Epidermal growth factor, its receptor, and related proteins

1986 • 186 citations

Mouse embryonic transforming growth factors related to those isolated from tumor cells.

1982 • 151 citations

Antibodies to the epidermal growth factor receptor block the biological activities of sarcoma growth factor.

1983 • 148 citations

Local effects of EGF, α‐TGF, and EGF‐like growth factors on lobuloalveolar development of the mouse mammary gland in vivo

1987 • 147 citations

Transforming growth factors and control of neoplastic cell growth

1987 • 141 citations

Differential Expression of Transforming Growth Factor-α during Prenatal Development of the Mouse

1985 • 138 citations

Amino acid sequence of the BSC-1 cell growth inhibitor (polyergin) deduced from the nucleotide sequence of the cDNA.

1988 • 134 citations

Biologically active precursor for transforming growth factor type alpha, released by retrovirally transformed cells.

1986 • 121 citations

Bi‐functional action of transforming growth factor‐β on DNA synthesis in early passage human fetal fibroblasts

1986 • 121 citations

Expression of rat transforming growth factor alpha mRNA during development occurs predominantly in the maternal decidua.

1987 • 121 citations

Recombinant human transforming growth factor-alpha stimulates the formation of osteoclast-like cells in long-term human marrow cultures.

1986 • 120 citations

Mouse embryos contain polypeptide growth factor(s) capable of inducing a reversible neoplastic phenotype in nontransformed cells in culture

1982 • 110 citations

Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha‐transforming growth factors in ras‐transformed mouse mammary epithelial cells

1987 • 108 citations

Physiological Effects of Transforming Growth Factor in the Newborn Mouse

1985 • 107 citations

Human transforming growth factor-α causes precocious eyelid opening in newborn mice

1985 • 101 citations

Transformation of normal rat kidney (NRK) cells by an infectious retrovirus carrying a synthetic rat type alpha transforming growth factor gene.

1987 • 100 citations

Visualization of Epidermal Growth Factor Receptors in Human Epidermis

1984 • 100 citations

Biologic mechanisms for the regulation of normal human keratinocyte proliferation and differentiation.

1988 • 90 citations

Actions of growth factors on plasma calcium. Epidermal growth factor and human transforming growth factor-alpha cause elevation of plasma calcium in mice.

1986 • 89 citations

Alpha-transforming growth factor secreted by untransformed bovine anterior pituitary cells in culture. I. Purification from conditioned medium.

1986 • 88 citations

Human term placenta contains transforming growth factors

1982 • 83 citations

Members of the src and ras oncogene families supplant the epidermal growth factor requirement of BALB/MK-2 keratinocytes and induce distinct alterations in their terminal differentiation program.

1985 • 74 citations

The human transforming growth factor type alpha coding sequence is not a direct-acting oncogene when overexpressed in NIH 3T3 cells.

1987 • 73 citations

The purification of fully active recombinant transforming growth factor alpha produced in Escherichia coli.

1986 • 68 citations

Structural properties of a soluble bioactive precursor for transforming growth factor-alpha.

1988 • 65 citations

Transforming growth factor‐α attenuates the acquisition of aromatase activity by cultured rat granulosa cells

1987 • 64 citations

Identification of an epidermal growth factor-related transforming growth factor from rat fetuses

1982 • 61 citations

Inhibition of parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by transforming growth factor alpha and epidermal growth factor.

1987 • 61 citations

Affinity labeling of a transforming growth factor receptor that does not interact with epidermal growth factor.

1982 • 60 citations

Transforming growth factor beta activates protein kinase C in microvessels isolated from immature rat brain

1988 • 43 citations

Control of normal differentiation of myeloid leukemic cells. VI. Inhibition of cell multiplication and the formation of macrophages

1975 • 37 citations

Transforming growth factors from a human tumor cell: characterization of transforming growth factor .beta. and identification of high molecular weight transforming growth factor .alpha.

1985 • 37 citations

Identification and subcellular localization of a 21-kilodalton molecule using affinity-purified antibodies against .alpha.-transforming growth factor

1987 • 11 citations

Endogeneous and Heterologous Expression of Transforming Growth Factor- in Mammalian Cells

1986 • 4 citations