Regulation of Lipid Signaling Pathways for Cell Survival and Apoptosis by bcl-2 in Prostate Carcinoma Cells

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

1996 • 1,773 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.

1992 • 1,063 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death.

1993 • 855 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

Regulators of cell death

1995 • 647 citations

Ceramide: an intracellular signal for apoptosis

1995 • 604 citations

Detection of the apoptosis-suppressing oncoprotein bc1-2 in hormone-refractory human prostate cancers.

1993 • 597 citations

Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluRl, in transfected CHO cells

1992 • 539 citations

Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo.

1995 • 537 citations

Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2

1993 • 424 citations

Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.

1996 • 371 citations

Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis.

1996 • 341 citations

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

1996 • 302 citations

Arachidonic acid in cell signaling

1993 • 295 citations

Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets

1984 • 265 citations

Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets.

1994 • 260 citations

Ordering the Cell Death Pathway

1996 • 231 citations

Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C

1995 • 228 citations

Serotonin stimulates phospholipase A2 and the release of arachidonic acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositolphospholipid hydrolysis.

1990 • 215 citations

Tight binding inhibitors of 85-kDa phospholipase A2 but not 14-kDa phospholipase A2 inhibit release of free arachidonate in thrombin-stimulated human platelets.

1994 • 186 citations

Stoichiometry and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agents.

1985 • 185 citations

Signal Transduction by Interferon-α Through Arachidonic Acid Metabolism

1991 • 155 citations

TNF receptors TR60 and TR80 can mediate apoptosis via induction of distinct signal pathways.

1994 • 145 citations

Expression of BCL-2 Oncoprotein and P53 Protein Accumulation in Bone Marrow Metastases of Androgen Independent Prostate Cancer

1997 • 132 citations

The gene family

1995 • 130 citations

Mitogenic signaling by epidermal growth factor (EGF), but not platelet-derived growth factor, requires arachidonic acid metabolism in BALB/c 3T3 cells. Modulation of EGF-dependent c-myc expression by prostaglandins.

1990 • 130 citations

Selective inhibition of platelet n — 8 lipoxygenase by 5,8,11-eicosatriynoic acid

1977 • 118 citations

Protein kinase C inhibition induces apoptosis and ceramide production through activation of a neutral sphingomyelinase.

1996 • 79 citations

Cell death signal transduction and Bcl-2 function

1996 • 62 citations

Signal transduction by bFGF, but not TGFβ1, involves arachidonic acid metabolism in endothelial cells

1991 • 53 citations

Combination adriamycin and suramin induces apoptosis in bcl-2 expressing prostate carcinoma cells

1995 • 50 citations

Stimulation of receptor-coupled phospholipase A₂by interferon-γ

1992 • 15 citations

v-Crk, an effector of the nerve growth factor signaling pathway, delays apoptotic cell death in neurotrophin-deprived PC12 cells

1996 • 10 citations

Thyrotropin-releasing hormone and lysine-bradykinin stimulate arachidonate liberation from rat anterior pituitary cells through different mechanisms.

1992 • 6 citations