Intracellular transport and sorting of mutant human proinsulins that fail to form hexamers.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Pathways of Protein Secretion in Eukaryotes

1985 • 1,050 citations

Constitutive and Regulated Secretion of Proteins

1987 • 1,021 citations

Protein Oligomerization in the Endoplasmic Reticulum

1989 • 993 citations

Ultrastructural localization of intracellular antigens by the use of protein A-gold complex.

1978 • 992 citations

Insulin: The Structure in the Crystal and its Reflection in Chemistry and Biology by

1972 • 831 citations

Monomeric insulins obtained by protein engineering and their medical implications

1988 • 493 citations

Inducible secretion of large, biologically potent von Willebrand factor multimers

1986 • 459 citations

Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation

1983 • 329 citations

Macro- and Micro-Domains in the Endocrine Pancreas

1982 • 306 citations

The trans-most cisternae of the Golgi complex: A compartment for sorting of secretory and plasma membrane proteins

1987 • 275 citations

Role of zinc in insulin biosynthesis

1980 • 251 citations

Specimen preparation for electron microscopy using low temperature embedding resins

1982 • 240 citations

Molecular Sorting in the Secretory Pathway

1989 • 155 citations

Condensation-sorting events in the rough endoplasmic reticulum of exocrine pancreatic cells.

1989 • 154 citations

Secretory protein targeting in a pituitary cell line: differential transport of foreign secretory proteins to distinct secretory pathways.

1985 • 145 citations

Re-routing of a secretory protein by fusion with human growth hormone sequences

1986 • 138 citations

A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway.

1988 • 135 citations

A portrait of the pancreatic B-Cell

1974 • 129 citations

The Relation of Conformation and Association of Insulin to Receptor Binding; X‐Ray and Circular‐Dichroism Studies on Bovine and Hystricomorph Insulins

1975 • 117 citations

Secretory granules of an anterior pituitary cell line, AtT-20, contain only mature forms of corticotropin and beta-lipotropin.

1981 • 105 citations

Familial Hyperproinsulinemia Due to a Proposed Defect in Conversion of Proinsulin to Insulin

1984 • 94 citations

A mutation in the B chain coding region is associated with impaired proinsulin conversion in a family with hyperproinsulinemia.

1987 • 81 citations

A subclass of proteins and sulfated macromolecules secreted by AtT-20 (mouse pituitary tumor) cells is sorted with adrenocorticotropin into dense secretory granules.

1983 • 69 citations

Efficient targeting to storage granules of human proinsulins with altered propeptide domain.

1988 • 64 citations

Interaction of zing with proinsulin

1970 • 59 citations

High resolution analysis of the secretory pathway in mammotrophs of the rat anterior pituitary.

1981 • 58 citations

Partial diversion of a mutant proinsulin (B10 aspartic acid) from the regulated to the constitutive secretory pathway in transfected AtT-20 cells.

1989 • 53 citations

Factors Controlling Packaging of Peptide Hormones into Secretory Granulesa

1987 • 27 citations

Somatostatin is targeted to the regulated secretory pathway of gonadotrophs in transgenic mice expressing a metallothionein-somatostatin gene.

1986 • 13 citations