The immunocytochemical localization of enkephalin in the central nervous system of the rat

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals

1978 • 1,426 citations

Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation

1969 • 1,355 citations

Opiates and endogenous opioid peptides

1977 • 1,282 citations

Stereospecific Binding of the Potent Narcotic Analgesic [ ³ H]Etorphine to Rat-Brain Homogenate

1973 • 1,055 citations

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

1975 • 981 citations

Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P.

1977 • 887 citations

Autoradiographic localization of opiate receptors in rat brain. I. Spinal cord and lower medulla

1977 • 863 citations

Immunohistochemical localization of enkephalin in rat brain and spinal cord

1978 • 814 citations

Immunohistochemical studies using antibodies to leucine-enkephalin: Initial observations on the nervous system of the rat

1976 • 767 citations

Pain reduction by focal electrical stimulation of the brain: An anatomical and behavioral analysis

1974 • 707 citations

The distribution of enkephalin-immunoreactive cell bodies in the rat central nervous system

1977 • 690 citations

Neurons containing beta-endorphin in rat brain exist separately from those containing enkephalin: immunocytochemical studies.

1978 • 656 citations

Stereospecific Interaction Between Narcotic Analgesics and a Synaptic Plasma Membrane Fraction of Rat Cerebral Cortex

1973 • 650 citations

Opioid peptide enkephalin: immunohistochemical mapping in rat central nervous system.

1977 • 617 citations

Anatomical neuroendocrinology

1982 • 592 citations

Autoradiographic localization of opiate receptors in rat brain. II. The brain stem

1977 • 573 citations

Autoradiographic localization of opiate receptors in rat brain. III. The telencephalon

1977 • 566 citations

Enkephalin-like immunoreactivity in gland cells and nerve terminals of the adrenal medulla

1978 • 554 citations

Analgesia induced in vivo by central administration of enkephalin in rat

1976 • 524 citations

The immunocytochemical localization of somatostatin-containing neurons in the rat central nervous system

1981 • 487 citations

ENKEPHALIN-LIKE IMMUNOREACTIVITY IN THE HUMAN GASTROINTESTINAL TRACT

1977 • 467 citations

Regional dissociation of beta-endorphin and enkephalin contents in rat brain and pituitary.

1977 • 451 citations

Enkephalin may mediate euphoria and drive-reduction reward

1977 • 450 citations

THE DISTRIBUTION OF METHIONINE‐ENKEPHALIN AND LEUCINE‐ENKEPHALIN IN THE BRAIN AND PERIPHERAL TISSUES

1977 • 443 citations

AN IMMUNOGLOBULIN-ENZYME BRIDGE METHOD FOR LOCALIZING TISSUE ANTIGENS

1969 • 423 citations

An endogenous morphine-like factor in mammalian brain

1975 • 393 citations

Immunohistochemical mapping of enkephalin containing cell bodies, fibers and nerve terminals in the brain stem of the rat

1979 • 382 citations

Immunocytochemical Localization of β-Endorphin-Containing Neurons in the Rat Brain

1981 • 380 citations

Enkephalin immunoreactive nerve fibres and cell bodies in sympathetic ganglia of the guinea-pig and rat

1979 • 346 citations

Neurotensin: immunohistochemical localization in rat central nervous system.

1977 • 341 citations

An improved perfusion fixation method for the testis

1977 • 327 citations

Search for an Endogenous Ligand for the Opiate Receptor

1975 • 315 citations

Regional distribution of leu and met enkephalin in rat brain

1977 • 307 citations

Reversal of morphine and stimulus-produced analgesia by subtotal spinal cord lesions

1977 • 303 citations

Neuronal actions of endorphins and enkephalins among brain regions: a comparative microiontophoretic study.

1977 • 299 citations

Evidence for enkephalin immunoreactive neurons in the medulla oblongata projecting to the spinal cord

1979 • 299 citations

Radioimmunoassay and characterization of enkephalins in rat tissues.

1978 • 288 citations

Electron microscopic localization of substance P and enkephalin in axon terminals related to dendrites of catecholaminergic neurons

1979 • 287 citations

Distribution of gastrin and CCK-like peptides in rat brain

1979 • 274 citations

Afferents to brain stem nuclei (brain stem raphe, nucleus reticularis pontis caudalis and nucleus gigantocellularis) in the rat as demonstrated by microiontophoretically applied horseradish peroxidase

1978 • 258 citations

Hypothalamic enkephalin neurones may regulate the neurohypophysis

1979 • 258 citations

Evidence for analgesic activity of enkephalin in the mouse

1976 • 252 citations

Immunocytochemical localization of enkephalin in the neostriatum of rat brain: A light and electron microscopic study

1980 • 241 citations

Immunocytochemical localization of methionine enkephalin: Preliminary observations

1977 • 230 citations

Morphine-like peptides in mammalian brain: isolation, structure elucidation, and interactions with the opiate receptor.

1976 • 226 citations

Respiratory and cardiovascular effects of met-enkephalin applied to the ventral surface of the brain stem

1977 • 207 citations

Effects of opiates and methionine-enkephalin on pontine and bulbar respiratory neurones of the cat

1978 • 207 citations

Morphine, enkephalin and the substantia gelatinosa

1976 • 188 citations

Effects of methionine-enkephalin on prolactin release and catecholamine levels and turnover in the median eminence

1977 • 177 citations

Isolation and structure identification of a morphine-like peptide “enkephalin” in bovine brain

1976 • 152 citations

RADIOIMMUNOASSAY OF METHIONINE‐AND LEUCINE‐ENKEPHALINS IN REGIONS OF RAT BRAIN AND COMPARISON WITH ENDORPHINS ESTIMATED BY A RADIORECEPTOR ASSAY

1978 • 149 citations

Enkephalin-containing pathway: amygdaloid efferents in the stria terminalis

1978 • 146 citations

Stimulation of prolactin release in the rat by intraventricular injection of β-end orphin and methionine-enkephalin

1977 • 138 citations

Effects of microiontophoretically applied methionine-enkephalin on single neurones in rat brainstem

1976 • 135 citations

Enkephalin-stimulated prolactin release

1976 • 133 citations

Improved immunoglobulin-enzyme bridge method for light microscopic demonstration of hormone-containing cells of the rat adenohypophysis

1975 • 124 citations

Effects of colchicine on axonal transport and ultrastructure of the hypothalamo-neurohypophyseal system of the rat

1971 • 122 citations

Criteria of reliability for light microscopic immunocytochemical staining

1980 • 120 citations

Somatostatin‐containing neurons in the rat brain: Widespread distribution revealed by immunocytochemistry after pretreatment with pronase

1978 • 120 citations

An immunohistochemical and radioimmunological study of the distribution of [Met5]- and [Leu5]-enkephalin in the gastrointestinal tract

1978 • 119 citations

Specificity in immunocytochemical staining.

1976 • 115 citations

The analgesic effect of electrical stimulation of the diencephalon and mesencephalon

1973 • 112 citations

Pronase pretreatment of tissue sections enhances sensitivity of the unlabelled antibody-enzyme (PAP) technique

1977 • 103 citations

Radioimmunoassay of enkephalins

1977 • 98 citations

Effects of enkephalin and morphine on Renshaw cells in feline spinal cord

1976 • 97 citations

On the locaticn of methicnine enkephalin neurons in rat striatum

1977 • 93 citations

Relationship between enkephalinergic neurons and the vasopressin‐oxytocin neuroendocrine system of the cat: An immunohistochemical study

1980 • 88 citations

Depression of nociceptive and other neurones in the brain by iontophoretically applied met-enkephalin

1976 • 87 citations

Excitation by morphine and enkephalin of single neurons of nucleus reticularis paragigantocellularis in the rat: a probable mechanism of analgesic action of opioids

1979 • 86 citations

Brain enkephalin distribution is unaltered by hypophysectomy

1978 • 76 citations

Immunohistochemical localization of enkephalins in median eminence and adenohypophysis

1979 • 75 citations

Pituitary somatotrophs contain [Met]enkephalin-like immunoreactivity.

1978 • 66 citations

Morphine-like peptides, leucine enkephalin and methionine enkephalin: interactions with the opiate receptor.

1976 • 62 citations

Intraventricular Met5-enkephalin causes unexpected lowering of pain threshold and narcotic withdrawal signs in rats

1976 • 56 citations

Colchicine effects on neurosecretory neurons and other hypothalamic and hypophysial cells, with special reference to changes in the cytoplasmic membranes

1976 • 53 citations

Multiple membrane actions of enkephalin revealed using cultured spinal neurons

1978 • 52 citations

Regional distribution of met-enkephalin within the amygdaloid complex and bed nucleus of the stria terminals

1978 • 48 citations

Immunocytochemical demonstration of anterior pituitary hormones in the pars tuberalis of long‐term hypophysectomized rats

1980 • 45 citations

Specific versus non-specific actions of opioids on hippocampal neurones in the rat brain

1979 • 45 citations

Nucleus raphe magnus: a common mediator of opiate- and stimulus-produced analgesia.

1976 • 36 citations

TSH Release-Inhibiting Activity of Leucine-Enkephalin

1979 • 35 citations

Enkephalins and Pituitary Hormone Release Modification of Responsiveness to LHRH

1979 • 34 citations

Enkephalins inhibit intestinal motility: mode of action.

1977 • 5 citations

Enkephalins and hippocampal neuronal circuits.

1979 • 4 citations